SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 THR A  13
PHE A  10
GLU A  11
GLY A   8
 None
None
CA  A1169 (-3.4A)
None
 1.21A 1icrA-2y6gA:
undetectable
1icrB-2y6gA:
undetectable		 1icrA-2y6gA:
21.50
1icrB-2y6gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 GLU A  11
GLY A   8
THR A  13
PHE A  10
 CA  A1169 (-3.4A)
None
None
None
 1.16A 1icrA-2y6gA:
undetectable
1icrB-2y6gA:
undetectable		 1icrA-2y6gA:
21.50
1icrB-2y6gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 THR A  13
PHE A  10
GLU A  11
GLY A   8
 None
None
CA  A1169 (-3.4A)
None
 1.24A 1icvC-2y6gA:
undetectable
1icvD-2y6gA:
undetectable		 1icvC-2y6gA:
21.50
1icvD-2y6gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 GLU A  11
GLY A   8
THR A  13
PHE A  10
 CA  A1169 (-3.4A)
None
None
None
 1.22A 1icvC-2y6gA:
undetectable
1icvD-2y6gA:
undetectable		 1icvC-2y6gA:
21.50
1icvD-2y6gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 GLU A  11
GLY A   8
THR A  13
PHE A  10
 CA  A1169 (-3.4A)
None
None
None
 1.15A 1kqbA-2y6gA:
undetectable
1kqbB-2y6gA:
undetectable		 1kqbA-2y6gA:
21.46
1kqbB-2y6gA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 GLU A  11
GLY A   9
THR A  13
PHE A  10
 CA  A1169 (-3.4A)
CA  A1169 (-3.6A)
None
None
 1.28A 1kqbA-2y6gA:
undetectable
1kqbB-2y6gA:
undetectable		 1kqbA-2y6gA:
21.46
1kqbB-2y6gA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y6g XYLANASE
(Rhodothermus
marinus) 		3 / 3 LEU A 167
LEU A   2
MET A   1
 None
 0.62A 2itzA-2y6gA:
undetectable		 2itzA-2y6gA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2y6g XYLANASE
(Rhodothermus
marinus) 		3 / 3 ASP A  29
THR A  13
PRO A  14
 BGC  A1173 (-3.7A)
None
None
 0.68A 2pynB-2y6gA:
undetectable		 2pynB-2y6gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2y6g XYLANASE
(Rhodothermus
marinus) 		3 / 3 ASP A  29
THR A  13
PRO A  14
 BGC  A1173 (-3.7A)
None
None
 0.67A 2qakB-2y6gA:
undetectable		 2qakB-2y6gA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		3 / 3 SER A  48
GLU A  95
ASP A  97
 None
 0.79A 2zulA-2y6gA:
undetectable		 2zulA-2y6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		3 / 3 SER A  48
GLU A  95
ASP A  97
 None
 0.78A 3dmhA-2y6gA:
undetectable		 3dmhA-2y6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 PRO A  77
GLY A  27
ASP A 111
ASP A  29
 None
None
None
BGC  A1173 (-3.7A)
 0.88A 4n48B-2y6gA:
undetectable		 4n48B-2y6gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 4 THR A  13
GLY A   9
ASP A 160
SER A  12
 None
CA  A1169 (-3.6A)
CA  A1169 (-2.2A)
None
 1.40A 4rfqA-2y6gA:
undetectable		 4rfqA-2y6gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		5 / 12 GLY A 154
ALA A  99
GLY A  98
ALA A  94
ILE A 157
 None
 0.91A 5kb6A-2y6gA:
undetectable		 5kb6A-2y6gA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2y6g XYLANASE
(Rhodothermus
marinus) 		5 / 12 GLY A 154
ALA A  99
GLY A  98
ALA A  94
ILE A 157
 None
 0.92A 5kb6B-2y6gA:
undetectable		 5kb6B-2y6gA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y6g XYLANASE
(Rhodothermus
marinus) 		4 / 5 ILE A 164
PHE A 132
ARG A  81
THR A 139
 None
 1.17A 5z84N-2y6gA:
undetectable
5z84W-2y6gA:
undetectable		 5z84N-2y6gA:
18.09
5z84W-2y6gA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2y6g XYLANASE
(Rhodothermus
marinus) 		5 / 12 GLY A 148
PRO A  51
VAL A  32
PRO A  40
GLY A  63
 None
 1.26A 6gngA-2y6gA:
undetectable		 6gngA-2y6gA:
14.75