SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASP A 103
TYR A 100
GLU A  96
 None
 0.85A 1vm1A-2y6pA:
undetectable		 1vm1A-2y6pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASP A 133
GLU A  96
TYR A 170
 None
None
IPA  A1236 ( 4.0A)
 0.81A 1wsvA-2y6pA:
undetectable		 1wsvA-2y6pA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 LEU A 120
GLU A 102
ILE A 104
 None
 0.60A 3czhA-2y6pA:
undetectable		 3czhA-2y6pA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 1.04A 3ekvB-2y6pA:
undetectable		 3ekvB-2y6pA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 0.98A 3nu4A-2y6pA:
undetectable		 3nu4A-2y6pA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ASP A 103
VAL A  99
ILE A 104
ILE A   6
VAL A  33
 None
 1.02A 3nujA-2y6pA:
undetectable		 3nujA-2y6pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 1.02A 3nuoA-2y6pA:
undetectable		 3nuoA-2y6pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ASP A 219
ASP A  95
GLY A  94
GLY A  73
TYR A 170
 MG  A1234 ( 2.3A)
MG  A1234 ( 2.6A)
CTP  A1233 (-3.5A)
CTP  A1233 (-3.4A)
IPA  A1236 ( 4.0A)
 0.92A 3prsA-2y6pA:
undetectable		 3prsA-2y6pA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 171
ILE A  89
ARG A   3
ILE A  90
ILE A 104
 None
 0.86A 4ax8A-2y6pA:
undetectable		 4ax8A-2y6pA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 171
ILE A  89
ARG A   3
ILE A  90
ILE A 104
 None
 0.87A 4azvA-2y6pA:
3.0		 4azvA-2y6pA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 1.06A 4q1wB-2y6pA:
undetectable		 4q1wB-2y6pA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 LYS A 174
LEU A 177
ASN A  91
ARG A   2
 None
 1.27A 4yv5B-2y6pA:
undetectable		 4yv5B-2y6pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 PHE A 108
GLU A 195
LEU A 199
GLY A 181
MET A 183
 None
IPA  A1236 (-3.9A)
None
None
None
 1.37A 4zjlA-2y6pA:
undetectable		 4zjlA-2y6pA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ARG A  15
GLY A 217
ASP A 223
ASP A  95
 CTP  A1233 (-3.7A)
None
None
MG  A1234 ( 2.6A)
 1.15A 5hp1A-2y6pA:
undetectable		 5hp1A-2y6pA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 THR A  66
ASP A  49
LEU A  70
ASP A  69
 None
 1.05A 5tdzA-2y6pA:
undetectable		 5tdzA-2y6pA:
21.63