SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  86
ILE A 124
ILE A 337
ILE A 142
VAL A 121
 None
CME  A  13 ( 4.9A)
None
None
None
 0.93A 1oipA-2y6vA:
3.0		 1oipA-2y6vA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 324
ILE A 142
ILE A 166
ILE A  86
PHE A  57
 None
 1.05A 2ygnA-2y6vA:
undetectable		 2ygnA-2y6vA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  62
GLY A  98
GLU A 239
VAL A  66
 None
 0.87A 4fgzA-2y6vA:
undetectable		 4fgzA-2y6vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  62
GLY A  98
GLU A 239
VAL A  66
 None
 0.86A 4fgzB-2y6vA:
undetectable		 4fgzB-2y6vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 313
ARG A 286
HIS A 340
 None
 1.13A 4fubA-2y6vA:
undetectable		 4fubA-2y6vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 296
ARG A 294
HIS A 323
LEU A 324
 None
None
CSO  A 298 (-4.7A)
None
 1.14A 4g5jA-2y6vA:
0.0		 4g5jA-2y6vA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  20
GLN A 150
GLY A 147
 None
 0.58A 4odoC-2y6vA:
undetectable		 4odoC-2y6vA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  93
SER A  61
GLY A  98
PHE A 224
GLY A  60
 None
 1.11A 4pevB-2y6vA:
4.6		 4pevB-2y6vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 170
LEU A 152
VAL A 141
LEU A 310
 None
 0.97A 4pwdA-2y6vA:
undetectable		 4pwdA-2y6vA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 232
SER A 229
GLN A 230
VAL A  66
TRP A  68
 None
 1.12A 5dpdB-2y6vA:
undetectable		 5dpdB-2y6vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 141
CYH A 154
HIS A 163
LEU A 161
 None
 1.49A 5hrqH-2y6vA:
undetectable
5hrqK-2y6vA:
undetectable
5hrqL-2y6vA:
undetectable		 5hrqH-2y6vA:
21.57
5hrqK-2y6vA:
4.27
5hrqL-2y6vA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 141
GLN A 158
CYH A 154
 None
 0.88A 5icxC-2y6vA:
undetectable
5icxF-2y6vA:
undetectable		 5icxC-2y6vA:
18.11
5icxF-2y6vA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A  59
ILE A 142
GLY A 143
GLY A 147
VAL A 121
 None
 1.04A 5o96C-2y6vA:
2.1
5o96D-2y6vA:
2.6		 5o96C-2y6vA:
20.35
5o96D-2y6vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  69
TYR A  70
ARG A  74
 None
 0.72A 5uunB-2y6vA:
undetectable		 5uunB-2y6vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 310
TRP A 114
ASP A 155
HIS A  59
 None
 1.08A 6nknC-2y6vA:
undetectable
6nknN-2y6vA:
undetectable
6nknP-2y6vA:
undetectable		 6nknC-2y6vA:
19.75
6nknN-2y6vA:
22.43
6nknP-2y6vA:
19.75