SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 GLU A 230
HIS A  46
HIS A  48
 ZN  A 301 (-2.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
 0.65A 1oe2A-2y7dA:
undetectable		 1oe2A-2y7dA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 VAL A 172
ALA A 205
HIS A 211
 None
 0.75A 1q23C-2y7dA:
undetectable		 1q23C-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 VAL A 172
ALA A 205
HIS A 211
 None
 0.69A 1q23H-2y7dA:
undetectable		 1q23H-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 VAL A 172
ALA A 205
HIS A 211
 None
 0.75A 1q23G-2y7dA:
undetectable		 1q23G-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 VAL A 172
ALA A 205
HIS A 211
 None
 0.79A 1q23L-2y7dA:
undetectable		 1q23L-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 6 ARG A  71
GLU A  76
PRO A 265
ALA A 268
 None
 1.41A 2ejfB-2y7dA:
undetectable		 2ejfB-2y7dA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 8 PRO A  27
ALA A  31
ALA A  34
GLU A  65
 None
 0.43A 3dtuC-2y7dA:
undetectable
3dtuD-2y7dA:
undetectable		 3dtuC-2y7dA:
20.25
3dtuD-2y7dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 8 LEU A  47
LEU A  23
ARG A 226
ILE A  45
 None
None
ZN  A 301 ( 4.2A)
None
 0.81A 3ln1A-2y7dA:
undetectable		 3ln1A-2y7dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 7 LEU A  47
LEU A  23
ARG A 226
ILE A  45
 None
None
ZN  A 301 ( 4.2A)
None
 0.80A 3ln1B-2y7dA:
undetectable		 3ln1B-2y7dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 6 PRO A 176
GLY A 178
LEU A 112
ASN A 113
 None
 0.97A 3zqtA-2y7dA:
undetectable		 3zqtA-2y7dA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		5 / 12 ILE A 217
LEU A 173
GLY A 181
VAL A 204
ALA A 205
 None
 1.05A 4fqsB-2y7dA:
undetectable		 4fqsB-2y7dA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 ARG A 260
THR A 201
TRP A 202
 None
 1.29A 4ug5A-2y7dA:
undetectable		 4ug5A-2y7dA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 7 PHE A 119
ASP A 116
GLY A 115
PHE A 114
 None
 0.90A 5h3aA-2y7dA:
undetectable		 5h3aA-2y7dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		5 / 9 ALA A 154
ILE A 157
ILE A 169
ALA A 200
LEU A 167
 None
 1.02A 5mvmA-2y7dA:
undetectable
5mvmE-2y7dA:
undetectable		 5mvmA-2y7dA:
13.17
5mvmE-2y7dA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 7 THR A 201
GLN A 170
MET A 104
THR A   7
 None
 1.26A 5u6mA-2y7dA:
2.9		 5u6mA-2y7dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		5 / 12 ALA A 132
LEU A 107
LEU A 129
ILE A 126
LEU A 156
 None
 1.42A 5uanB-2y7dA:
undetectable		 5uanB-2y7dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		3 / 3 ILE A 169
VAL A 142
PRO A 140
 None
 0.62A 5uunA-2y7dA:
undetectable		 5uunA-2y7dA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		5 / 12 ILE A 197
LEU A 167
GLY A 110
ALA A 109
LEU A 107
 None
 1.16A 5zwrA-2y7dA:
undetectable		 5zwrA-2y7dA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		4 / 6 LEU A  23
THR A  11
GLY A  12
ARG A  50
 None
 1.12A 6gtqB-2y7dA:
undetectable
6gtqD-2y7dA:
undetectable		 6gtqB-2y7dA:
19.72
6gtqD-2y7dA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Candidatus
Cloacimonas
acidaminovorans) 		5 / 11 ILE A 225
LEU A 247
ASP A 231
GLY A 206
ALA A   9
 None
 1.15A 6r2eF-2y7dA:
undetectable		 6r2eF-2y7dA:
24.78