SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		8 / 12 ALA A  51
LYS A  53
LEU A 105
LEU A 109
MET A 110
GLY A 113
LEU A 160
ASP A 171
 B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.49A 1m17A-2y7jA:
25.9		 1m17A-2y7jA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 LYS A  53
GLU A  77
LEU A 109
MET A 110
GLY A 113
LEU A 160
ASP A 171
 None
None
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.74A 1m17A-2y7jA:
25.9		 1m17A-2y7jA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 GLU A 139
LEU A 286
GLU A 283
ALA A 282
HIS A 145
 None
 1.22A 1mj2A-2y7jA:
undetectable		 1mj2A-2y7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 GLU A 139
LEU A 286
GLU A 283
ALA A 282
HIS A 145
 None
 1.22A 1mj2C-2y7jA:
undetectable		 1mj2C-2y7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 GLU A 139
LEU A 286
GLU A 283
ALA A 282
HIS A 145
 None
 1.24A 1mjoA-2y7jA:
undetectable		 1mjoA-2y7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 GLU A 139
LEU A 286
GLU A 283
ALA A 282
HIS A 145
 None
 1.23A 1mjoB-2y7jA:
undetectable		 1mjoB-2y7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 GLU A 139
LEU A 286
GLU A 283
ALA A 282
HIS A 145
 None
 1.24A 1mjoC-2y7jA:
undetectable		 1mjoC-2y7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 5 ILE A 268
TRP A 257
LEU A 272
PRO A 232
 None
 1.25A 1s8fA-2y7jA:
undetectable
1s8fB-2y7jA:
undetectable		 1s8fA-2y7jA:
15.80
1s8fB-2y7jA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 ILE A  30
VAL A  38
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.73A 1uwhA-2y7jA:
15.7		 1uwhA-2y7jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 ILE A  30
VAL A  38
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.74A 1uwhB-2y7jA:
15.7		 1uwhB-2y7jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 7 ILE A  30
LEU A  81
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.88A 1uwjA-2y7jA:
7.4		 1uwjA-2y7jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 7 ILE A  30
LYS A  53
LEU A  81
ILE A  90
 B49  A1294 (-3.9A)
None
None
None
 0.75A 1uwjA-2y7jA:
7.4		 1uwjA-2y7jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 ALA A  51
GLY A 113
ASP A 117
LEU A 160
ASP A 171
PHE A 172
 B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
None
 0.96A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 VAL A  38
LEU A  93
LEU A 105
LEU A 109
MET A 110
 None
None
None
B49  A1294 ( 4.7A)
None
 0.45A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 VAL A  38
LYS A  53
LEU A  93
LEU A 105
MET A 110
 None
 0.65A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 ALA A  51
LYS A  53
LEU A 105
GLY A 113
ASP A 117
LEU A 160
 B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.66A 2itoA-2y7jA:
24.6		 2itoA-2y7jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LYS A  53
GLY A 113
ASP A 117
LEU A 160
ASP A 171
 None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.66A 2itzA-2y7jA:
24.4		 2itzA-2y7jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		3 / 3 LEU A 105
LEU A 109
MET A 110
 None
B49  A1294 ( 4.7A)
None
 0.35A 2itzA-2y7jA:
24.4		 2itzA-2y7jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 GLY A  31
VAL A  38
LYS A  53
LEU A  81
LEU A 105
LEU A 160
ASP A 171
 B49  A1294 (-4.0A)
None
None
None
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.60A 2ivuA-2y7jA:
26.7		 2ivuA-2y7jA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 VAL A  38
ALA A  51
LEU A  93
LEU A 109
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.38A 3bbtB-2y7jA:
22.2		 3bbtB-2y7jA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LEU A 109
GLY A 113
LEU A 160
ASP A 171
PHE A 172
 None
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
None
 0.87A 3bbtB-2y7jA:
22.2		 3bbtB-2y7jA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LYS A  53
GLY A 113
LEU A 160
ASP A 171
PHE A 172
 None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
None
 1.08A 3bbtD-2y7jA:
22.5		 3bbtD-2y7jA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 7 LYS A  53
LEU A 105
LEU A 109
MET A 110
ILE A  90
 None
None
B49  A1294 ( 4.7A)
None
None
 1.46A 3gp0A-2y7jA:
24.2		 3gp0A-2y7jA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 8 ALA A  51
LEU A 105
LEU A 109
MET A 110
 B49  A1294 (-3.2A)
None
B49  A1294 ( 4.7A)
None
 0.29A 3lfaA-2y7jA:
23.6		 3lfaA-2y7jA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 11 ILE A  30
ALA A  51
MET A 110
GLY A 113
LEU A 160
SER A 170
ASP A 171
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
 0.90A 3miyA-2y7jA:
24.0		 3miyA-2y7jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 11 ILE A  30
ALA A  51
PHE A 107
MET A 110
GLY A 113
LEU A 160
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.73A 3miyA-2y7jA:
24.0		 3miyA-2y7jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 9 ILE A  30
ALA A  51
MET A 110
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.81A 3miyB-2y7jA:
24.0		 3miyB-2y7jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 9 ILE A  30
ALA A  51
PHE A 107
MET A 110
GLY A 113
LEU A 160
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.68A 3miyB-2y7jA:
24.0		 3miyB-2y7jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 5 VAL A 141
LEU A 138
ILE A 222
ALA A 218
 None
 0.92A 3n8yB-2y7jA:
undetectable		 3n8yB-2y7jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 GLY A  31
VAL A  38
ALA A  51
LYS A  53
LEU A  81
ILE A  91
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.6A)
 0.76A 3ohtA-2y7jA:
4.1		 3ohtA-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 GLY A  31
VAL A  38
ALA A  51
LYS A  53
LEU A  81
GLY A 113
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
 0.91A 3ohtB-2y7jA:
19.5		 3ohtB-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 VAL A  38
ALA A  51
LYS A  53
LEU A  81
ILE A  91
GLY A 113
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.6A)
B49  A1294 (-3.6A)
 0.94A 3ohtB-2y7jA:
19.5		 3ohtB-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		8 / 12 VAL A  38
ALA A  51
GLU A  77
LEU A  81
ILE A  91
PHE A 107
LEU A 144
HIS A 151
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.6A)
B49  A1294 (-4.0A)
None
None
 0.76A 3rgfA-2y7jA:
24.0		 3rgfA-2y7jA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 ILE A 268
LEU A 272
PHE A 233
MET A 244
 None
 0.95A 3sj1X-2y7jA:
undetectable		 3sj1X-2y7jA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		3 / 3 HIS A  79
HIS A 177
ILE A  80
 None
 0.74A 3u52A-2y7jA:
undetectable
3u52C-2y7jA:
undetectable		 3u52A-2y7jA:
21.22
3u52C-2y7jA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		9 / 12 VAL A  38
ALA A  51
LYS A  53
LEU A 105
LEU A 109
MET A 110
GLY A 113
ASP A 117
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.60A 3ug2A-2y7jA:
25.0		 3ug2A-2y7jA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 ILE A  30
GLY A  33
VAL A  38
ALA A  51
LEU A 160
SER A 170
ASP A 171
 B49  A1294 (-3.9A)
None
None
B49  A1294 (-3.2A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
 1.05A 3v5wA-2y7jA:
10.9		 3v5wA-2y7jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 12 ALA A  51
LEU A 109
MET A 110
GLY A 113
LEU A 160
 B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.33A 3zbfA-2y7jA:
25.6		 3zbfA-2y7jA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 12 LEU A  81
ASP A 153
LYS A 155
ASN A 158
ASP A 171
 None
None
None
None
B49  A1294 (-4.2A)
 0.67A 4an2A-2y7jA:
25.1		 4an2A-2y7jA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 7 ILE A 268
LEU A 272
PHE A 233
MET A 244
 None
 1.02A 4hbfA-2y7jA:
undetectable		 4hbfA-2y7jA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		8 / 12 GLY A  31
VAL A  38
ALA A  51
LYS A  53
LEU A 105
GLY A 113
ASP A 117
LEU A 160
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.66A 4i22A-2y7jA:
22.2		 4i22A-2y7jA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		8 / 12 VAL A  38
ALA A  51
ILE A  91
ASP A 117
ASP A 153
LYS A 155
ASN A 158
LEU A 160
 None
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
None
None
None
None
B49  A1294 (-4.4A)
 0.86A 4i41A-2y7jA:
29.7		 4i41A-2y7jA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 ILE A  94
THR A  92
VAL A  42
ASP A  28
 None
 1.17A 4iaqA-2y7jA:
2.7		 4iaqA-2y7jA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 10 ILE A  30
ALA A  51
GLY A 113
LEU A 160
SER A 170
ASP A 171
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
 0.72A 4ks8A-2y7jA:
30.6		 4ks8A-2y7jA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 7 VAL A  38
ALA A  51
MET A 110
LEU A 160
 None
B49  A1294 (-3.2A)
None
B49  A1294 (-4.4A)
 0.59A 4l9iA-2y7jA:
12.0		 4l9iA-2y7jA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 8 GLY A  33
VAL A  38
ALA A  51
LYS A  53
MET A 110
LEU A 160
 None
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-4.4A)
 0.89A 4l9iB-2y7jA:
28.3		 4l9iB-2y7jA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 GLY A  31
VAL A  38
ALA A  51
LEU A 160
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 (-4.4A)
 0.24A 4o0wA-2y7jA:
31.2		 4o0wA-2y7jA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 5 PHE A 291
PHE A 290
LEU A 272
PRO A 232
 None
 1.40A 4o8zA-2y7jA:
undetectable		 4o8zA-2y7jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 10 ILE A  30
ALA A  51
LYS A  53
ILE A  91
LEU A 109
LEU A 160
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 ( 4.6A)
B49  A1294 ( 4.7A)
B49  A1294 (-4.4A)
 0.60A 4rz7A-2y7jA:
11.7		 4rz7A-2y7jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 11 ALA A  51
LYS A  53
MET A 110
GLY A 113
ASN A 158
LEU A 160
 B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 1.00A 4wa9A-2y7jA:
22.4		 4wa9A-2y7jA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LYS A  53
MET A 110
GLY A 113
ASN A 158
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.90A 4wa9B-2y7jA:
25.4		 4wa9B-2y7jA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 ALA A  51
LYS A  53
LEU A 105
LEU A 109
GLY A 113
ASP A 117
LEU A 160
 B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.49A 4wkqA-2y7jA:
25.5		 4wkqA-2y7jA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 ALA A  51
LEU A 109
MET A 110
LEU A 160
 B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
B49  A1294 (-4.4A)
 0.18A 4xoyA-2y7jA:
11.1		 4xoyA-2y7jA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 6 ALA A  51
LEU A 109
MET A 110
LEU A 160
 B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
B49  A1294 (-4.4A)
 0.25A 4xp3A-2y7jA:
27.7		 4xp3A-2y7jA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 10 VAL A  38
ALA A  51
LYS A  53
MET A 110
GLY A 113
LEU A 160
ASP A 171
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.80A 5aabA-2y7jA:
24.0		 5aabA-2y7jA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 10 VAL A  38
ALA A  51
LYS A  53
MET A 110
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.54A 5aacA-2y7jA:
4.0		 5aacA-2y7jA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 12 VAL A  38
ALA A  51
LEU A 109
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.46A 5h2uA-2y7jA:
11.8		 5h2uA-2y7jA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 VAL A  38
ALA A  51
LEU A 109
GLY A 113
LEU A 160
ASP A 171
 None
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.84A 5h2uB-2y7jA:
8.1		 5h2uB-2y7jA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 ILE A  30
ALA A  51
ILE A  91
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.56A 5i9xA-2y7jA:
24.3		 5i9xA-2y7jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 ILE A  30
ALA A  51
LYS A  53
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.64A 5i9xA-2y7jA:
24.3		 5i9xA-2y7jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 ILE A  30
ALA A  51
LYS A  53
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.67A 5i9yA-2y7jA:
24.1		 5i9yA-2y7jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 9 ILE A  30
GLY A  31
VAL A  38
ALA A  51
ILE A  91
MET A 110
 B49  A1294 (-3.9A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
None
 0.46A 5lw1B-2y7jA:
23.8		 5lw1B-2y7jA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 10 GLY A  31
VAL A  38
ALA A  51
ILE A  91
LEU A 109
MET A 110
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
B49  A1294 ( 4.7A)
None
 0.54A 5lw1E-2y7jA:
23.4		 5lw1E-2y7jA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 GLY A  31
VAL A  38
ALA A  51
LEU A 109
MET A 110
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
 0.43A 5lw1H-2y7jA:
12.5		 5lw1H-2y7jA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 ILE A  30
GLY A  31
VAL A  38
ALA A  51
LYS A  53
GLY A 113
GLU A 114
 B49  A1294 (-3.9A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 ( 4.7A)
 0.72A 5mafA-2y7jA:
31.3		 5mafA-2y7jA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 ILE A  30
GLY A  31
VAL A  38
LYS A  53
GLU A  77
GLY A 113
GLU A 114
 B49  A1294 (-3.9A)
B49  A1294 (-4.0A)
None
None
None
B49  A1294 (-3.6A)
B49  A1294 ( 4.7A)
 0.80A 5mafA-2y7jA:
31.3		 5mafA-2y7jA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 12 MET A 134
LEU A 137
ILE A 268
LEU A 271
LEU A 226
 None
 1.23A 5toaB-2y7jA:
undetectable		 5toaB-2y7jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 10 ILE A 268
LEU A 223
PHE A 224
LEU A 125
ALA A 124
 None
 1.18A 5y7pB-2y7jA:
undetectable		 5y7pB-2y7jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 10 ILE A 268
LEU A 223
PHE A 224
LEU A 125
ALA A 124
 None
 1.16A 5y7pD-2y7jA:
undetectable		 5y7pD-2y7jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  77
LEU A 109
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.88A 5y7zA-2y7jA:
28.0		 5y7zA-2y7jA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  77
LEU A 109
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.88A 5y7zA-2y7jA:
28.0		 5y7zA-2y7jA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 9 VAL A  38
LYS A  53
ILE A  91
PHE A 107
ASP A 171
 None
None
B49  A1294 ( 4.6A)
B49  A1294 (-4.0A)
B49  A1294 (-4.2A)
 0.99A 5yf9X-2y7jA:
27.1		 5yf9X-2y7jA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 GLY A  31
VAL A  38
ALA A  51
LEU A 105
ASP A 117
LEU A 160
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-4.4A)
 0.73A 5yu9B-2y7jA:
22.4		 5yu9B-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 12 VAL A  38
ALA A  51
GLY A 113
ASP A 117
ASP A 171
 None
B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.2A)
 0.70A 5yu9C-2y7jA:
21.9		 5yu9C-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		5 / 12 VAL A  38
ALA A  51
LEU A 105
GLY A 113
ASP A 117
 None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
None
 0.49A 5yu9C-2y7jA:
21.9		 5yu9C-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		6 / 12 VAL A  38
ALA A  51
GLY A 113
ASP A 117
LEU A 160
ASP A 171
 None
B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.69A 5yu9D-2y7jA:
22.5		 5yu9D-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		4 / 7 VAL A  38
ILE A  91
PHE A 107
ASP A 171
 None
B49  A1294 ( 4.6A)
B49  A1294 (-4.0A)
B49  A1294 (-4.2A)
 0.71A 5ywmX-2y7jA:
27.0		 5ywmX-2y7jA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		3 / 3 LYS A  53
LEU A 160
ASP A 171
 None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.67A 5zv2A-2y7jA:
23.1		 5zv2A-2y7jA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		7 / 12 VAL A  38
ALA A  51
LYS A  53
ILE A  91
MET A 110
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
B49  A1294 ( 4.6A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.38A 6bsdA-2y7jA:
23.3		 6bsdA-2y7jA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens) 		3 / 3 LEU A 280
GLY A 220
PHE A 252
 None
 0.61A 6exiC-2y7jA:
undetectable		 6exiC-2y7jA:
11.36