SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		3 / 3 ASN A 276
PHE A 247
VAL A 185
 None
 0.86A 1kijA-2y7lA:
undetectable		 1kijA-2y7lA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		5 / 11 ILE A 173
THR A  28
PRO A  29
VAL A  22
LEU A 272
 None
 1.19A 1rv7A-2y7lA:
undetectable
1rv7B-2y7lA:
undetectable		 1rv7A-2y7lA:
16.61
1rv7B-2y7lA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		3 / 3 SER A 124
GLY A 123
ARG A 171
 None
 0.60A 1t9wA-2y7lA:
undetectable		 1t9wA-2y7lA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		3 / 3 SER A 124
ASP A 259
ASP A 130
 None
 0.83A 3iv6A-2y7lA:
undetectable		 3iv6A-2y7lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		3 / 3 SER A 124
ASP A 259
ASP A 130
 None
 0.83A 3iv6C-2y7lA:
undetectable		 3iv6C-2y7lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		3 / 3 THR A 122
ASN A 213
GLU A  86
 None
 0.81A 3v4tA-2y7lA:
undetectable
3v4tC-2y7lA:
undetectable		 3v4tA-2y7lA:
21.94
3v4tC-2y7lA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		5 / 12 ILE A 214
ASN A 213
GLU A  86
ILE A 173
VAL A 245
 None
 1.26A 4a97B-2y7lA:
2.6
4a97C-2y7lA:
2.6		 4a97B-2y7lA:
19.71
4a97C-2y7lA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		4 / 8 ILE A 173
GLY A 121
ASN A 213
GLU A  27
 None
 0.90A 4fgjA-2y7lA:
undetectable
4fgjB-2y7lA:
undetectable		 4fgjA-2y7lA:
20.77
4fgjB-2y7lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		5 / 10 VAL A   6
GLY A   5
ASP A  48
LEU A  39
ASN A  40
 None
 1.21A 5x6yB-2y7lA:
undetectable		 5x6yB-2y7lA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 2y7l AGGLUTININ-LIKE ALS9
PROTEIN
(Candida
albicans) 		4 / 5 SER A 162
VAL A 161
ASN A 224
PRO A 186
 None
 1.49A 6fi4A-2y7lA:
undetectable
6fi4B-2y7lA:
undetectable		 6fi4A-2y7lA:
19.38
6fi4B-2y7lA:
9.26