SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		10 / 11 THR A 104
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
 None
 0.84A 2y7kA-2y7rA:
30.6		 2y7kA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		10 / 11 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 None
 0.77A 2y7kA-2y7rA:
30.6		 2y7kA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		7 / 7 PRO A  92
SER A  95
PHE A  99
ILE A 126
PRO A 285
GLY A 286
TRP A 289
 None
 0.55A 2y7kA-2y7rA:
30.6		 2y7kA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		9 / 10 THR A 104
GLY A 107
TYR A 110
PHE A 111
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
 None
 0.84A 2y7kB-2y7rA:
30.7		 2y7kB-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		9 / 10 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 None
 0.76A 2y7kB-2y7rA:
30.7		 2y7kB-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		5 / 5 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.35A 2y7kB-2y7rA:
30.7		 2y7kB-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		12 / 12 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ARG A 248
ILE A 273
 None
 0.61A 2y7kC-2y7rA:
32.5		 2y7kC-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		11 / 12 THR A 104
ILE A 106
GLY A 107
TYR A 110
PHE A 111
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
 None
 0.60A 2y7kD-2y7rA:
31.8		 2y7kD-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		9 / 10 THR A 104
GLY A 107
TYR A 110
GLY A 152
PHE A 167
HIS A 169
HIS A 206
PRO A 246
ILE A 273
 None
 0.96A 2y7pA-2y7rA:
30.2		 2y7pA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		8 / 10 THR A 104
ILE A 106
GLY A 107
TYR A 110
GLY A 152
PHE A 167
PRO A 246
ILE A 273
 None
 0.82A 2y7pA-2y7rA:
30.2		 2y7pA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		5 / 6 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.34A 2y7pA-2y7rA:
21.9		 2y7pA-2y7rA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		9 / 9 THR A 104
ILE A 106
GLY A 107
TYR A 110
GLY A 152
PHE A 167
HIS A 169
ARG A 248
ILE A 273
 None
 0.53A 2y7wA-2y7rA:
31.0		 2y7wA-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		7 / 10 THR A 104
GLY A 107
PHE A 111
GLY A 152
HIS A 206
PRO A 246
ILE A 273
 None
 0.69A 2y7wB-2y7rA:
31.3		 2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		7 / 10 THR A 104
GLY A 107
PHE A 111
THR A 204
HIS A 206
PRO A 246
ILE A 273
 None
 0.88A 2y7wB-2y7rA:
31.3		 2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		8 / 10 THR A 104
ILE A 106
GLY A 107
PHE A 111
GLY A 152
HIS A 169
PRO A 246
ILE A 273
 None
 0.53A 2y7wB-2y7rA:
31.3		 2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		8 / 10 THR A 104
ILE A 106
GLY A 107
PHE A 111
HIS A 169
THR A 204
PRO A 246
ILE A 273
 None
 0.69A 2y7wB-2y7rA:
31.3		 2y7wB-2y7rA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		7 / 7 THR A 104
ILE A 106
GLY A 107
PHE A 111
PHE A 167
HIS A 169
ILE A 273
 None
 0.54A 2y7wC-2y7rA:
31.1		 2y7wC-2y7rA:
95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		5 / 12 CYH A 173
THR A 244
ILE A 218
HIS A 179
LEU A 236
 None
 1.22A 3gwxB-2y7rA:
undetectable		 3gwxB-2y7rA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		5 / 12 PHE A 111
THR A 104
HIS A 206
LEU A 138
VAL A 147
 None
 1.21A 3sp9B-2y7rA:
undetectable		 3sp9B-2y7rA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		4 / 7 PHE A 167
HIS A 206
ILE A 273
HIS A 169
 None
 1.13A 3t01A-2y7rA:
undetectable		 3t01A-2y7rA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		4 / 4 VAL A 199
GLY A 198
ARG A 220
VAL A 209
 None
 1.25A 5d4nA-2y7rA:
undetectable
5d4nB-2y7rA:
undetectable		 5d4nA-2y7rA:
17.29
5d4nB-2y7rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		4 / 6 PHE A 175
HIS A 196
MET A 186
LEU A 241
 None
 1.41A 5dzka-2y7rA:
undetectable
5dzko-2y7rA:
undetectable		 5dzka-2y7rA:
20.00
5dzko-2y7rA:
1.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2y7r LYSR-TYPE REGULATORY
PROTEIN
(Burkholderia
sp.
DNT) 		4 / 7 ILE A 235
LEU A 236
MET A 174
LEU A 259
 None
 0.93A 5u4sA-2y7rA:
undetectable		 5u4sA-2y7rA:
22.22