SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 229
ARG A 233
VAL A 203
LEU A 209
 None
 0.88A 1fiqC-2y89A:
undetectable		 1fiqC-2y89A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 1.04A 1hxwA-2y89A:
undetectable		 1hxwA-2y89A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  15
VAL A  70
ALA A  34
SER A  33
 None
None
None
SO4  A1248 ( 4.4A)
 0.93A 1p6kA-2y89A:
undetectable		 1p6kA-2y89A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 11 SER A 200
PHE A  58
LEU A  54
VAL A  18
VAL A  52
 None
 1.44A 1q23I-2y89A:
undetectable		 1q23I-2y89A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 0.99A 1sh9B-2y89A:
undetectable		 1sh9B-2y89A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 0.99A 3ektA-2y89A:
undetectable		 3ektA-2y89A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  32
ASP A  36
VAL A  10
VAL A  12
 None
 0.64A 3fi0I-2y89A:
undetectable		 3fi0I-2y89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A   6
ILE A 212
ALA A 213
THR A 216
 None
 0.95A 3mdrA-2y89A:
undetectable		 3mdrA-2y89A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  52
VAL A 168
SER A 200
 None
 0.73A 3n8xB-2y89A:
undetectable		 3n8xB-2y89A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 0.94A 3ttpA-2y89A:
undetectable		 3ttpA-2y89A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 0.97A 3ttpB-2y89A:
undetectable		 3ttpB-2y89A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 0.98A 3u7sB-2y89A:
undetectable		 3u7sB-2y89A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 122
ALA A 106
GLY A 104
GLU A 109
ASN A 110
 None
None
SO4  A1246 (-3.4A)
None
SO4  A1252 (-3.7A)
 1.04A 3v3oB-2y89A:
undetectable		 3v3oB-2y89A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 185
THR A 170
ILE A 172
GLY A 176
 None
 0.95A 4eq4A-2y89A:
undetectable		 4eq4A-2y89A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 185
THR A 170
ILE A 172
GLY A 176
 None
 0.96A 4eqlA-2y89A:
undetectable		 4eqlA-2y89A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 185
THR A 170
ILE A 172
GLY A 176
 None
 0.95A 4eqlB-2y89A:
undetectable		 4eqlB-2y89A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 185
THR A 170
ILE A 172
GLY A 176
 None
 0.91A 4l39B-2y89A:
undetectable		 4l39B-2y89A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 171
GLY A 176
ASP A 184
GLY A 136
ILE A 134
 None
 1.02A 4njvB-2y89A:
undetectable		 4njvB-2y89A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  92
ALA A  91
GLY A  82
GLY A  83
ASP A  86
 None
None
SO4  A1246 (-3.3A)
SO4  A1246 (-3.4A)
None
 1.10A 4qvwK-2y89A:
undetectable
4qvwL-2y89A:
undetectable		 4qvwK-2y89A:
24.51
4qvwL-2y89A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  92
ALA A  91
GLY A  82
GLY A  83
ASP A  86
 None
None
SO4  A1246 (-3.3A)
SO4  A1246 (-3.4A)
None
 1.10A 4qvwY-2y89A:
undetectable
4qvwZ-2y89A:
undetectable		 4qvwY-2y89A:
24.51
4qvwZ-2y89A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  36
PRO A   8
TYR A 230
LEU A 229
 None
 1.25A 5bmvB-2y89A:
undetectable		 5bmvB-2y89A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 106
GLY A 128
GLY A 104
GLY A 142
ALA A 126
 None
None
SO4  A1246 (-3.4A)
None
None
 1.19A 5c0oE-2y89A:
undetectable		 5c0oE-2y89A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  52
VAL A 168
SER A 200
ILE A 212
 None
 0.83A 5jw1B-2y89A:
undetectable		 5jw1B-2y89A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  74
VAL A  35
ASP A  36
 None
 0.65A 5x23A-2y89A:
undetectable		 5x23A-2y89A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A   6
VAL A 225
LEU A 229
VAL A 203
 None
 0.95A 5x7zA-2y89A:
undetectable		 5x7zA-2y89A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  60
ARG A  85
THR A 105
ALA A  57
 None
SO4  A1246 (-4.1A)
SO4  A1246 (-3.0A)
SO4  A1246 ( 3.9A)
 1.16A 6ma6A-2y89A:
undetectable		 6ma6A-2y89A:
12.61