SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		4 / 6 ARG A 100
SER A  93
ASP A 134
PRO A  98
 None
 1.45A 3jqaA-2y8cA:
undetectable		 3jqaA-2y8cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		4 / 6 ARG A 100
SER A  93
ASP A 134
PRO A  98
 None
 1.42A 3jqaC-2y8cA:
undetectable		 3jqaC-2y8cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		4 / 6 ARG A 100
SER A  93
ASP A 134
PRO A  98
 None
 1.42A 3jqaD-2y8cA:
undetectable		 3jqaD-2y8cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		5 / 12 ALA A  53
LEU A   3
LEU A 139
LEU A  31
ILE A 116
 None
None
None
None
DUQ  A 400 ( 4.9A)
 1.08A 3uvvA-2y8cA:
undetectable		 3uvvA-2y8cA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		5 / 12 LEU A   3
SER A 141
ILE A   5
LEU A  31
LEU A 101
 None
 1.24A 3vw1B-2y8cA:
undetectable		 3vw1B-2y8cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		3 / 3 ARG A 113
ARG A 160
ILE A  54
 None
DUQ  A 400 (-3.8A)
None
 0.70A 4b7qA-2y8cA:
undetectable		 4b7qA-2y8cA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		3 / 3 ARG A 113
ARG A 160
ILE A  54
 None
DUQ  A 400 (-3.8A)
None
 0.69A 4b7qC-2y8cA:
undetectable		 4b7qC-2y8cA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		3 / 3 LYS A  96
THR A  97
ILE A 130
 None
 0.76A 4e0fB-2y8cA:
undetectable		 4e0fB-2y8cA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		4 / 6 THR A  97
LEU A 120
TYR A 128
LEU A  39
 None
 1.05A 4wozA-2y8cA:
undetectable
4wozB-2y8cA:
undetectable		 4wozA-2y8cA:
22.90
4wozB-2y8cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		4 / 5 LEU A 120
TYR A 128
LEU A  39
THR A  97
 None
 1.09A 4wozF-2y8cA:
undetectable
4wozH-2y8cA:
undetectable		 4wozF-2y8cA:
22.90
4wozH-2y8cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
(Plasmodium
falciparum) 		3 / 3 THR A 123
PRO A  90
ARG A  91
 None
 0.64A 5nd7B-2y8cA:
undetectable		 5nd7B-2y8cA:
15.88