SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		3 / 3 PHE A  17
LEU A 165
MET A 150
 None
 0.89A 1mx1D-2y8eA:
2.0		 1mx1D-2y8eA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		5 / 12 THR A  44
GLY A  19
GLN A  21
ILE A  45
PHE A  74
 MG  A1177 ( 3.1A)
None
GNP  A1176 (-4.8A)
None
None
 1.30A 2azxA-2y8eA:
undetectable		 2azxA-2y8eA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		5 / 12 THR A  44
GLY A  19
GLN A  21
ILE A  45
PHE A  74
 MG  A1177 ( 3.1A)
None
GNP  A1176 (-4.8A)
None
None
 1.27A 2azxB-2y8eA:
undetectable		 2azxB-2y8eA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		5 / 12 PHE A  13
ALA A 170
VAL A  91
LEU A 165
LEU A  65
 None
 1.21A 4qzuA-2y8eA:
undetectable		 4qzuA-2y8eA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		4 / 8 ARG A  73
GLY A  46
GLN A  71
THR A  44
 None
None
None
MG  A1177 ( 3.1A)
 1.10A 5sxqB-2y8eA:
undetectable		 5sxqB-2y8eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		4 / 8 ARG A  73
GLY A  46
GLN A  71
THR A  44
 None
None
None
MG  A1177 ( 3.1A)
 1.09A 5syjA-2y8eA:
undetectable		 5syjA-2y8eA:
13.40