SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		4 / 6 LEU A 340
ASN A 361
ILE A 407
PHE A 420
 None
 1.08A 2jn3A-2y8fA:
1.4		 2jn3A-2y8fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		5 / 12 THR A 389
LEU A 391
ILE A 422
THR A 429
LEU A 334
 None
 1.33A 3a51B-2y8fA:
undetectable		 3a51B-2y8fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		5 / 12 ILE A 397
ARG A 374
LEU A 360
ILE A 422
LEU A 358
 GOL  A1452 (-4.7A)
CL  A1449 ( 3.9A)
None
None
None
 1.14A 3k2hB-2y8fA:
undetectable		 3k2hB-2y8fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		5 / 10 LEU A 340
VAL A 342
ARG A 359
ILE A 407
THR A 389
 None
 1.08A 4j14A-2y8fA:
undetectable		 4j14A-2y8fA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		5 / 10 ILE A 397
ALA A 435
THR A 389
LEU A 387
ILE A 407
 GOL  A1452 (-4.7A)
None
None
None
None
 1.20A 4km0A-2y8fA:
undetectable		 4km0A-2y8fA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		4 / 8 THR A 325
GLY A 326
LEU A 371
ALA A 364
 None
 0.73A 5vw5A-2y8fA:
undetectable		 5vw5A-2y8fA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens) 		4 / 4 ILE A 407
LEU A 360
HIS A 437
ALA A 435
 None
None
GOL  A1452 ( 4.6A)
None
 1.03A 6ck2C-2y8fA:
undetectable
6ck2D-2y8fA:
undetectable		 6ck2C-2y8fA:
8.70
6ck2D-2y8fA:
10.14