SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 SER A 347
VAL A 225
GLY A 501
GLY A 349
MET A 481
 None
 0.93A 1fduC-2y8nA:
undetectable		 1fduC-2y8nA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 11 TYR A 729
TYR A 726
TRP A 578
LEU A 648
TYR A 571
 None
 1.18A 1fkpA-2y8nA:
undetectable		 1fkpA-2y8nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 GLN A 439
LEU A 351
TYR A 228
LEU A 331
 None
 1.08A 1hk3A-2y8nA:
undetectable		 1hk3A-2y8nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 10 LEU A  96
LEU A 376
ILE A 428
PHE A 335
ILE A 348
 None
 1.23A 1i18A-2y8nA:
undetectable
1i18B-2y8nA:
undetectable		 1i18A-2y8nA:
7.58
1i18B-2y8nA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.31A 1jhoA-2y8nA:
undetectable		 1jhoA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 8 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.32A 1jhqA-2y8nA:
undetectable		 1jhqA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.32A 1jhrA-2y8nA:
undetectable		 1jhrA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 8 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.31A 1jhvA-2y8nA:
undetectable		 1jhvA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.31A 1jhyA-2y8nA:
1.3		 1jhyA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.33A 1l4nA-2y8nA:
undetectable		 1l4nA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 6 GLY A 394
VAL A 210
ALA A 137
SER A 139
 None
 1.03A 1p6kA-2y8nA:
1.1		 1p6kA-2y8nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 5 MET A 312
ASN A  99
THR A 101
MET A  86
 None
 1.39A 1xmuA-2y8nA:
0.0		 1xmuA-2y8nA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 GLY A 345
PHE A 405
ASN A 808
SER A 506
GLN A 807
 None
 1.36A 2a8tA-2y8nA:
undetectable		 2a8tA-2y8nA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 LEU A 512
GLY A 509
ASP A 494
ALA A 527
ALA A 628
 None
 1.15A 2br4D-2y8nA:
undetectable		 2br4D-2y8nA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 11 PHE A 118
ALA A 161
ALA A 393
ALA A 137
SER A 116
 None
 1.08A 2bxeB-2y8nA:
undetectable		 2bxeB-2y8nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 5 LEU A 410
LEU A 427
MET A 433
THR A 450
 None
 1.37A 2oaxD-2y8nA:
undetectable		 2oaxD-2y8nA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 5 LEU A 455
LEU A 410
MET A 472
THR A 826
 None
 1.28A 2oaxD-2y8nA:
undetectable		 2oaxD-2y8nA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_2
(MINERALOCORTICOID
RECEPTOR)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 4 LEU A 504
TRP A 498
LEU A 445
MET A 837
 None
 1.44A 2oaxE-2y8nA:
0.0		 2oaxE-2y8nA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 LEU A 424
LEU A 232
PRO A 440
GLY A 349
 None
 0.94A 2po5A-2y8nA:
undetectable		 2po5A-2y8nA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 LEU A 464
LEU A 466
GLY A 467
VAL A 429
ARG A 381
 None
 1.25A 2q7lA-2y8nA:
undetectable		 2q7lA-2y8nA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 ILE A 885
PHE A 874
GLY A 398
GLY A 397
 None
 0.76A 2qx4A-2y8nA:
undetectable
2qx4B-2y8nA:
undetectable		 2qx4A-2y8nA:
13.60
2qx4B-2y8nA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 GLY A 222
THR A 530
GLN A 221
PHE A 110
 None
 1.06A 2qx4A-2y8nA:
undetectable
2qx4B-2y8nA:
undetectable		 2qx4A-2y8nA:
13.60
2qx4B-2y8nA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 THR A 404
CYH A 389
GLN A 343
PHE A 108
 None
 1.17A 2qx4A-2y8nA:
undetectable
2qx4B-2y8nA:
undetectable		 2qx4A-2y8nA:
13.60
2qx4B-2y8nA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 6 ILE A 885
PHE A 874
GLY A 398
GLY A 397
 None
 0.73A 2qx6A-2y8nA:
undetectable
2qx6B-2y8nA:
undetectable		 2qx6A-2y8nA:
13.60
2qx6B-2y8nA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 LEU A 408
ARG A 381
ARG A 105
TYR A  44
HIS A 334
 None
 1.28A 2vavC-2y8nA:
0.0		 2vavC-2y8nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 LEU A 408
ARG A 381
ARG A 105
TYR A  44
HIS A 334
 None
 1.29A 2vavD-2y8nA:
0.0		 2vavD-2y8nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 ALA A 527
SER A 347
GLY A 502
ALA A 507
CYH A 499
 None
 1.47A 2vh3A-2y8nA:
undetectable		 2vh3A-2y8nA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 GLY A 502
ILE A 219
ALA A 507
GLU A 224
 None
 0.88A 2x0pA-2y8nA:
1.0		 2x0pA-2y8nA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		3 / 3 TYR A  44
GLU A 880
THR A 404
 None
 1.03A 2y7hB-2y8nA:
undetectable		 2y7hB-2y8nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 LEU A 464
LEU A 466
VAL A 429
ARG A 381
THR A 826
 None
 1.47A 2yloA-2y8nA:
undetectable		 2yloA-2y8nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 ASN A 789
GLY A 713
ASN A 714
THR A 893
 None
 0.89A 2yoeB-2y8nA:
2.2
2yoeC-2y8nA:
2.8		 2yoeB-2y8nA:
16.40
2yoeC-2y8nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 10 ARG A 892
ASN A 808
GLU A 505
GLY A 778
GLN A 810
 None
 1.03A 2z71A-2y8nA:
0.0
2z71C-2y8nA:
0.0		 2z71A-2y8nA:
17.47
2z71C-2y8nA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 PRO A 440
LEU A 408
ASN A 435
ILE A 327
LEU A 424
 None
 1.38A 3a51B-2y8nA:
0.8		 3a51B-2y8nA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 VAL A 143
PHE A 117
LEU A 174
ALA A  51
PHE A 390
 None
 1.18A 3apxA-2y8nA:
undetectable		 3apxA-2y8nA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		3 / 3 SER A 753
GLY A 397
GLY A 402
 None
 0.53A 3bogA-2y8nA:
undetectable
3bogC-2y8nA:
undetectable		 3bogA-2y8nA:
undetectable
3bogC-2y8nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 PHE A 760
GLY A 756
GLY A 759
PHE A 685
ASP A 887
 None
 1.40A 3dlcA-2y8nA:
undetectable		 3dlcA-2y8nA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 GLN A 356
THR A 422
LEU A 377
TYR A 359
LEU A 355
 None
 1.20A 3fsuA-2y8nA:
undetectable		 3fsuA-2y8nA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 11 GLN A 356
THR A 422
LEU A 377
TYR A 359
LEU A 355
 None
 1.22A 3fsuE-2y8nA:
0.0		 3fsuE-2y8nA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 ILE A 794
GLY A 713
ALA A 719
ILE A 642
ALA A 783
 None
 1.10A 3jb1A-2y8nA:
undetectable		 3jb1A-2y8nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 ILE A 327
LEU A 408
THR A 422
THR A 437
 None
 1.27A 3nxuA-2y8nA:
undetectable		 3nxuA-2y8nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 GLN A 845
HIS A 843
GLU A 637
PHE A 405
 None
 1.20A 3ql6A-2y8nA:
undetectable		 3ql6A-2y8nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 ALA A  76
VAL A  79
LEU A  83
LEU A 611
 None
 0.80A 3roxA-2y8nA:
undetectable		 3roxA-2y8nA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 VAL A 373
LEU A 408
LEU A 424
GLY A 432
ALA A 431
 None
 1.12A 3rr3D-2y8nA:
1.1		 3rr3D-2y8nA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 TYR A 729
TYR A 726
LEU A 648
TYR A 571
 None
 1.05A 3v81A-2y8nA:
1.5		 3v81A-2y8nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 ASP A 777
ARG A 870
HIS A 843
HIS A 755
 None
 1.50A 3zodA-2y8nA:
undetectable		 3zodA-2y8nA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 11 MET A 597
ASN A 604
GLY A 624
GLY A 222
GLU A 505
 None
 1.07A 4a6nB-2y8nA:
undetectable		 4a6nB-2y8nA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 SER A 141
GLY A 398
GLY A 394
VAL A 589
ILE A 538
 None
 0.83A 4ctkC-2y8nA:
undetectable		 4ctkC-2y8nA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 VAL A 395
ALA A 137
PHE A 214
SER A 216
VAL A 399
 None
 1.10A 4eckB-2y8nA:
undetectable		 4eckB-2y8nA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 8 GLY A 532
GLY A 222
LEU A 346
VAL A 225
GLU A 224
 None
 1.40A 4fgzA-2y8nA:
undetectable		 4fgzA-2y8nA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 8 SER A 443
SER A 409
GLY A 352
GLY A 412
 None
 0.67A 4fo4B-2y8nA:
undetectable		 4fo4B-2y8nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 GLY A 624
LYS A 602
SER A 632
GLY A 534
ASP A 598
 None
 0.94A 4fp9A-2y8nA:
undetectable		 4fp9A-2y8nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 GLY A 624
LYS A 602
SER A 632
GLY A 534
ASP A 598
 None
 0.94A 4fp9C-2y8nA:
undetectable		 4fp9C-2y8nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 GLY A 624
LYS A 602
SER A 632
GLY A 534
ASP A 598
 None
 0.94A 4fp9F-2y8nA:
undetectable		 4fp9F-2y8nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.33A 4kqiA-2y8nA:
1.3		 4kqiA-2y8nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 LEU A 464
LEU A 466
VAL A 429
ARG A 381
THR A 826
 None
 1.39A 4olmA-2y8nA:
undetectable		 4olmA-2y8nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 GLY A 526
VAL A 225
ILE A 226
PRO A 524
ILE A 327
 None
 1.06A 4pd4C-2y8nA:
3.3		 4pd4C-2y8nA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 THR A 773
ALA A 764
THR A 765
ALA A 766
 None
 0.56A 4qw0K-2y8nA:
undetectable		 4qw0K-2y8nA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 THR A 773
ALA A 764
THR A 765
ALA A 766
 None
 0.57A 4qw0Y-2y8nA:
undetectable		 4qw0Y-2y8nA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 VAL A 395
GLN A 343
VAL A 337
ILE A 387
ASN A 406
 None
 1.40A 4s0vA-2y8nA:
2.0		 4s0vA-2y8nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 11 ALA A 497
TYR A 485
GLY A 501
SER A 528
GLY A 509
 None
 1.27A 4xnxA-2y8nA:
undetectable		 4xnxA-2y8nA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 8 ALA A 527
PRO A 614
GLY A 509
ALA A 497
GLY A 525
 None
 1.25A 4zjzB-2y8nA:
undetectable		 4zjzB-2y8nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 10 TYR A 228
ASN A 227
PRO A 231
GLY A 345
GLN A 343
 None
 1.44A 4zp0A-2y8nA:
0.0		 4zp0A-2y8nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 7 VAL A 140
SER A 141
GLY A 759
VAL A 761
 None
 0.89A 5fpdB-2y8nA:
undetectable		 5fpdB-2y8nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 11 TYR A 726
PHE A 644
VAL A 575
ILE A 211
ILE A 538
 None
 1.16A 5hw8A-2y8nA:
undetectable
5hw8D-2y8nA:
undetectable		 5hw8A-2y8nA:
9.63
5hw8D-2y8nA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 ALA A  51
PHE A 537
ILE A 750
PHE A 214
GLY A 532
 None
 1.14A 5jlcA-2y8nA:
undetectable		 5jlcA-2y8nA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 9 CYH A 748
LEU A 504
GLU A 637
VAL A 225
SER A 409
 None
 1.26A 5v1sB-2y8nA:
2.6		 5v1sB-2y8nA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		5 / 12 PRO A 757
GLY A 640
GLY A 539
ILE A 885
VAL A 399
 None
 0.89A 5zhmB-2y8nA:
undetectable		 5zhmB-2y8nA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 5 ASP A 138
ILE A 160
PHE A 390
ASN A 191
 None
 1.18A 6a93B-2y8nA:
3.5		 6a93B-2y8nA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		3 / 3 TYR A 415
PRO A 513
LEU A 512
 None
 0.88A 6beoA-2y8nA:
undetectable		 6beoA-2y8nA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		3 / 3 TYR A 468
PRO A 440
LEU A 408
 None
 0.74A 6beoA-2y8nA:
undetectable		 6beoA-2y8nA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT
(Clostridium
scatologenes) 		4 / 6 CYH A 879
GLY A 148
ARG A 105
ARG A 865
 None
 1.28A 6gtqB-2y8nA:
undetectable
6gtqD-2y8nA:
undetectable		 6gtqB-2y8nA:
11.39
6gtqD-2y8nA:
3.80