SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 8 GLU A  75
HIS A  17
LEU A  20
LEU A  59
 None
 0.96A 1hwiB-2y8vA:
undetectable		 1hwiB-2y8vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 8 GLU A  75
HIS A  17
LEU A  20
LEU A  59
 None
 0.96A 1hwiC-2y8vA:
undetectable		 1hwiC-2y8vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.07A 1kifA-2y8vA:
undetectable		 1kifA-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.07A 1kifB-2y8vA:
undetectable		 1kifB-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.07A 1kifC-2y8vA:
undetectable		 1kifC-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.06A 1kifD-2y8vA:
undetectable		 1kifD-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.06A 1kifE-2y8vA:
undetectable		 1kifE-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.07A 1kifF-2y8vA:
undetectable		 1kifF-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.07A 1kifG-2y8vA:
undetectable		 1kifG-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.06A 1kifH-2y8vA:
undetectable		 1kifH-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		5 / 12 GLY A 224
ILE A 242
VAL A 221
PHE A 253
ALA A 163
 None
 0.89A 1nv8B-2y8vA:
undetectable		 1nv8B-2y8vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		3 / 3 TYR A 177
ARG A  99
GLN A  95
 None
 0.96A 1tw4A-2y8vA:
undetectable		 1tw4A-2y8vA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.02A 1ve9A-2y8vA:
undetectable		 1ve9A-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		5 / 12 GLY A 224
ILE A 242
VAL A 221
PHE A 253
ALA A 163
 None
 0.95A 1vq1B-2y8vA:
undetectable		 1vq1B-2y8vA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 LEU A  90
GLY A  88
LEU A 115
PRO A  64
 None
 0.93A 1ya4B-2y8vA:
undetectable		 1ya4B-2y8vA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.08A 2du8G-2y8vA:
undetectable		 2du8G-2y8vA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.04A 2du8J-2y8vA:
undetectable		 2du8J-2y8vA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 TYR A 196
PRO A 229
THR A 227
TRP A 262
 None
 1.29A 2q6kA-2y8vA:
undetectable		 2q6kA-2y8vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		8 / 9 TYR A  16
GLY A  92
ALA A  93
ASP A 130
GLU A 132
GLN A 194
TYR A 196
TRP A 262
 None
 0.57A 2uy4A-2y8vA:
21.1		 2uy4A-2y8vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 LEU A 127
LEU A 147
PHE A 155
LEU A 124
 None
 1.00A 2vq5B-2y8vA:
undetectable		 2vq5B-2y8vA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		9 / 11 TYR A  16
GLY A  92
ALA A  93
ASP A 130
GLU A 132
GLN A 194
TYR A 196
ASN A 197
TRP A 262
 None
 0.67A 2xtkA-2y8vA:
21.8		 2xtkA-2y8vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		8 / 10 TYR A  16
GLY A  92
ALA A  93
ASP A 130
GLU A 132
GLN A 194
TYR A 196
TRP A 262
 None
 0.62A 2xtkB-2y8vA:
21.8		 2xtkB-2y8vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 5 PRO A 269
THR A  41
VAL A  40
GLY A  39
 None
 1.17A 3elzA-2y8vA:
undetectable		 3elzA-2y8vA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		5 / 11 GLY A  92
ASP A 130
GLU A 132
TYR A 196
TRP A 262
 None
 0.46A 3wqvA-2y8vA:
19.1		 3wqvA-2y8vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		5 / 11 GLY A  92
ASP A 130
GLU A 132
TYR A 196
TRP A 262
 None
 0.48A 3wqwA-2y8vA:
19.1		 3wqwA-2y8vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 8 GLY A 126
ILE A  45
GLU A  75
LEU A  79
 None
 0.78A 4mwzB-2y8vA:
undetectable		 4mwzB-2y8vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		5 / 12 ALA A 160
GLY A  91
GLY A  92
GLY A  88
LEU A 124
 None
 0.97A 4n48B-2y8vA:
undetectable		 4n48B-2y8vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		4 / 8 GLY A  92
GLU A 132
TYR A 196
TRP A 262
 None
 0.50A 5gqbA-2y8vA:
11.0		 5gqbA-2y8vA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 2y8v CLASS III CHITINASE,
PUTATIVE
(Aspergillus
fumigatus) 		5 / 9 TYR A 177
ASP A 176
GLY A 168
ALA A 163
VAL A 162
 None
 1.11A 5v3cA-2y8vA:
7.3		 5v3cA-2y8vA:
14.34