SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 8 TYR A  97
PHE A 342
THR A 104
LEU A  57
 None
 1.29A 1ea1A-2y9xA:
undetectable		 1ea1A-2y9xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.62A 1rjoA-2y9xA:
undetectable		 1rjoA-2y9xA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 6 VAL A  27
ILE A 176
ILE A  23
ASP A 152
 None
 0.75A 1uwhB-2y9xA:
undetectable		 1uwhB-2y9xA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.64A 1w2zA-2y9xA:
undetectable		 1w2zA-2y9xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.66A 1w2zB-2y9xA:
undetectable		 1w2zB-2y9xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.64A 1w2zC-2y9xA:
undetectable		 1w2zC-2y9xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.67A 1w2zD-2y9xA:
undetectable		 1w2zD-2y9xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2y9x LECTIN-LIKE FOLD
PROTEIN
(Agaricus
bisporus) 		4 / 5 TRP E 106
GLY E 100
ASN E 101
GLY E 102
 None
 0.94A 1zlqA-2y9xE:
undetectable		 1zlqA-2y9xE:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A  94
HIS A 296
HIS A 259
 CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
 0.75A 2dysN-2y9xA:
undetectable		 2dysN-2y9xA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 12 LEU A 303
ALA A 304
GLN A 307
LEU A 355
PHE A 135
 None
 1.32A 2oaxF-2y9xA:
undetectable		 2oaxF-2y9xA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.65A 2oqeA-2y9xA:
undetectable		 2oqeA-2y9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.64A 2oqeB-2y9xA:
undetectable		 2oqeB-2y9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.65A 2oqeC-2y9xA:
undetectable		 2oqeC-2y9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.65A 2oqeD-2y9xA:
undetectable		 2oqeD-2y9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.64A 2oqeF-2y9xA:
undetectable		 2oqeF-2y9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2y9x POLYPHENOL OXIDASE
LECTIN-LIKE FOLD
PROTEIN
(Agaricus
bisporus;
Agaricus
bisporus) 		3 / 3 SER A   2
ASP A 348
ASP E  60
 None
 0.77A 2plwA-2y9xA:
undetectable		 2plwA-2y9xA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.64A 2w0qA-2y9xA:
undetectable		 2w0qA-2y9xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.65A 2w0qB-2y9xA:
undetectable		 2w0qB-2y9xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
VAL A 299
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.86A 2wkoF-2y9xA:
undetectable		 2wkoF-2y9xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.31A 2zweA-2y9xA:
20.5
2zweB-2y9xA:
undetectable		 2zweA-2y9xA:
23.56
2zweB-2y9xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.35A 2zwfA-2y9xA:
20.4
2zwfB-2y9xA:
undetectable		 2zwfA-2y9xA:
23.56
2zwfB-2y9xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.37A 2zwgA-2y9xA:
20.5
2zwgB-2y9xA:
undetectable		 2zwgA-2y9xA:
23.56
2zwgB-2y9xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.65A 3hiiA-2y9xA:
undetectable		 3hiiA-2y9xA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.66A 3hiiB-2y9xA:
undetectable		 3hiiB-2y9xA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2y9x LECTIN-LIKE FOLD
PROTEIN
POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 ILE A 328
ARG E  52
ILE E  55
THR A 324
 None
 1.29A 3ia4C-2y9xA:
undetectable		 3ia4C-2y9xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2y9x LECTIN-LIKE FOLD
PROTEIN
(Agaricus
bisporus) 		3 / 3 ALA E 117
VAL E 118
GLN E 144
 None
 0.68A 3of4B-2y9xE:
undetectable		 3of4B-2y9xE:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A  85
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.33A 3qpkA-2y9xA:
undetectable		 3qpkA-2y9xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A  85
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.31A 3qpkB-2y9xA:
undetectable		 3qpkB-2y9xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 ASN A 298
TRP A 138
ASP A 367
 None
 1.06A 4a7tA-2y9xA:
undetectable
4a7tF-2y9xA:
undetectable		 4a7tA-2y9xA:
16.45
4a7tF-2y9xA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 6 ASP A 300
ARG A  95
HIS A  94
LEU A 255
 None
None
CU  A 400 (-3.2A)
None
 1.23A 4cevA-2y9xA:
undetectable
4cevC-2y9xA:
undetectable		 4cevA-2y9xA:
20.45
4cevC-2y9xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 6 ARG A  95
HIS A  94
LEU A 255
ASP A 300
 None
CU  A 400 (-3.2A)
None
None
 1.24A 4cevD-2y9xA:
undetectable
4cevE-2y9xA:
undetectable		 4cevD-2y9xA:
20.45
4cevE-2y9xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 6 ARG A  95
HIS A  94
LEU A 255
ASP A 300
 None
CU  A 400 (-3.2A)
None
None
 1.25A 4cevE-2y9xA:
undetectable
4cevF-2y9xA:
undetectable		 4cevE-2y9xA:
20.45
4cevF-2y9xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 8 LEU A 131
PHE A 116
THR A 163
ASP A  30
 None
 1.07A 4drjB-2y9xA:
undetectable		 4drjB-2y9xA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y9x LECTIN-LIKE FOLD
PROTEIN
(Agaricus
bisporus) 		3 / 3 GLY E 100
SER E  99
TRP E 106
 None
 0.76A 4e7cD-2y9xE:
undetectable		 4e7cD-2y9xE:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 6 PRO A 341
GLY A  58
ALA A  69
GLN A 133
 None
 1.12A 4g0uA-2y9xA:
undetectable		 4g0uA-2y9xA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.40A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.42A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.23A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.43A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		6 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.35A 4p6sB-2y9xA:
21.2		 4p6sB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 7 HIS A  85
HIS A  61
HIS A 263
HIS A 259
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
 0.98A 4p6sB-2y9xA:
21.2		 4p6sB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 12 ASP A 300
HIS A 296
HIS A 263
HIS A 295
LEU A 255
 None
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
None
 1.42A 4yhaA-2y9xA:
undetectable		 4yhaA-2y9xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 7 TYR A  97
TYR A  82
PRO A 341
PHE A 288
 None
 1.18A 5aclA-2y9xA:
undetectable		 5aclA-2y9xA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 ASP A 336
VAL A 315
LEU A  89
 HO  A 402 (-3.6A)
None
None
 0.64A 5e5jB-2y9xA:
undetectable		 5e5jB-2y9xA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 ALA A  80
PRO A 341
GLY A  12
LEU A  57
 None
 0.82A 5eslA-2y9xA:
undetectable		 5eslA-2y9xA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 7 THR A 271
ASP A 269
TYR A 201
GLY A 212
 None
 1.00A 5hwaA-2y9xA:
undetectable		 5hwaA-2y9xA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.36A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  61
HIS A  94
HIS A 259
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.45A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.46A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.23A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  94
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.49A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.49A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.31A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  61
HIS A  94
HIS A 259
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.48A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.45A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.23A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.47A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.38A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  61
HIS A  94
HIS A 259
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.45A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.46A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.49A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A  61
HIS A  85
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.40A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A  61
HIS A  94
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.23A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 263
HIS A 259
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.07A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 263
HIS A 296
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 0.86A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2y9x LECTIN-LIKE FOLD
PROTEIN
(Agaricus
bisporus) 		3 / 3 VAL E  84
GLN E  90
CYH E  92
 None
 0.89A 5icxC-2y9xE:
undetectable
5icxF-2y9xE:
undetectable		 5icxC-2y9xE:
21.15
5icxF-2y9xE:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 10 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.40A 5m8nA-2y9xA:
20.5		 5m8nA-2y9xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 10 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.44A 5m8nB-2y9xA:
20.4		 5m8nB-2y9xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 9 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.39A 5m8nC-2y9xA:
20.4		 5m8nC-2y9xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.33A 5m8rA-2y9xA:
20.5		 5m8rA-2y9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 8 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.35A 5m8rB-2y9xA:
20.5		 5m8rB-2y9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		6 / 8 HIS A  85
HIS A 259
ASN A 260
HIS A 263
GLY A 281
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 ( 4.5A)
0TR  A 410 (-4.0A)
 0.44A 5m8rC-2y9xA:
20.5		 5m8rC-2y9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 8 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.40A 5m8rD-2y9xA:
20.4		 5m8rD-2y9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.81A 5mhwA-2y9xA:
undetectable		 5mhwA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mhxA-2y9xA:
undetectable		 5mhxA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mhyA-2y9xA:
undetectable		 5mhyA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mhzA-2y9xA:
undetectable		 5mhzA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mi1A-2y9xA:
undetectable		 5mi1A-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mi2A-2y9xA:
undetectable		 5mi2A-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5miaA-2y9xA:
undetectable		 5miaA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mibA-2y9xA:
undetectable		 5mibA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.79A 5micA-2y9xA:
undetectable		 5micA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5midA-2y9xA:
undetectable		 5midA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mieA-2y9xA:
undetectable		 5mieA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A  85
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.29A 5migA-2y9xA:
undetectable		 5migA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.40A 5z0fA-2y9xA:
21.0
5z0fB-2y9xA:
undetectable		 5z0fA-2y9xA:
9.92
5z0fB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  94
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 1.48A 5z0fA-2y9xA:
21.0
5z0fB-2y9xA:
undetectable		 5z0fA-2y9xA:
9.92
5z0fB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.35A 5z0gA-2y9xA:
20.4
5z0gB-2y9xA:
undetectable		 5z0gA-2y9xA:
9.92
5z0gB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.39A 5z0hA-2y9xA:
20.4
5z0hB-2y9xA:
undetectable		 5z0hA-2y9xA:
9.92
5z0hB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.37A 5z0iA-2y9xA:
20.5
5z0iB-2y9xA:
undetectable		 5z0iA-2y9xA:
9.92
5z0iB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.36A 5z0jA-2y9xA:
20.4
5z0jB-2y9xA:
undetectable		 5z0jA-2y9xA:
9.92
5z0jB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.35A 5z0kA-2y9xA:
20.3
5z0kB-2y9xA:
undetectable		 5z0kA-2y9xA:
9.92
5z0kB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.39A 5z0lA-2y9xA:
20.4
5z0lB-2y9xA:
undetectable		 5z0lA-2y9xA:
9.92
5z0lB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.49A 5z0mA-2y9xA:
20.5
5z0mB-2y9xA:
undetectable		 5z0mA-2y9xA:
11.68
5z0mB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A  61
CYH A  83
HIS A  85
HIS A  94
 CU  A 400 (-3.2A)
CU  A 400 (-3.7A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
 0.17A 5zrdA-2y9xA:
12.2		 5zrdA-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 259
HIS A 263
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
 0.24A 5zrdA-2y9xA:
12.2		 5zrdA-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A  61
HIS A  85
PHE A  90
HIS A  94
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
None
CU  A 400 (-3.2A)
 1.08A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A 259
HIS A 263
PHE A 292
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 ( 4.9A)
None
CU  A 401 (-3.2A)
 0.35A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A  61
CYH A  83
HIS A  85
HIS A  94
PHE A 292
 CU  A 400 (-3.2A)
CU  A 400 (-3.7A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 401 ( 4.9A)
 0.28A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.06A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A 259
HIS A 263
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.34A 5zrdC-2y9xA:
27.6		 5zrdC-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A  61
CYH A  83
HIS A  85
HIS A  94
PHE A 292
 CU  A 400 (-3.2A)
CU  A 400 (-3.7A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 401 ( 4.9A)
 0.30A 5zrdC-2y9xA:
27.6		 5zrdC-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.10A 5zrdC-2y9xA:
27.6		 5zrdC-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A  61
CYH A  83
HIS A  85
HIS A  94
PHE A 292
 CU  A 400 (-3.2A)
CU  A 400 (-3.7A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 401 ( 4.9A)
 0.32A 5zrdD-2y9xA:
27.5		 5zrdD-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.09A 5zrdD-2y9xA:
27.5		 5zrdD-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A 259
HIS A 263
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.36A 5zrdD-2y9xA:
27.6		 5zrdD-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2y9x LECTIN-LIKE FOLD
PROTEIN
POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 12 HIS A 251
GLY E  13
VAL E 150
THR A  87
GLY A 245
 None
 1.02A 6brdB-2y9xA:
undetectable		 6brdB-2y9xA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 TYR A  97
HIS A 296
PHE A 292
 None
CU  A 401 (-3.2A)
CU  A 401 ( 4.9A)
 1.06A 6esmA-2y9xA:
undetectable		 6esmA-2y9xA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 VAL A 172
GLU A 171
ILE A 162
 None
 0.56A 6f7lB-2y9xA:
undetectable		 6f7lB-2y9xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 6 PRO A  64
ILE A  60
GLY A  62
TYR A  82
 None
 1.12A 6gqiA-2y9xA:
undetectable		 6gqiA-2y9xA:
21.59