SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 538
PHE B 566
ALA B 599
SER B 598
LEU B 554
 None
 1.12A 1igxA-2y9yB:
undetectable		 1igxA-2y9yB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 975
PHE A 976
HIS B 613
VAL B 615
 None
 1.01A 1lh6A-2y9yA:
undetectable		 1lh6A-2y9yA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 5 GLU B 268
LEU B 261
LEU B 264
LEU B 262
 None
 1.10A 1np1A-2y9yB:
undetectable		 1np1A-2y9yB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 934
PHE A 930
ILE A 896
TYR A 926
HIS A 805
 None
 1.17A 1ot7A-2y9yA:
0.0		 1ot7A-2y9yA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 8 PHE B 241
LEU B 236
GLY B 229
ASP B 232
 None
 0.97A 1rmtC-2y9yB:
undetectable		 1rmtC-2y9yB:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
(Saccharomyces
cerevisiae) 		5 / 12 SER A 881
ASP A 878
GLU A 882
PRO A 812
ARG A 936
 None
 1.48A 1s14A-2y9yA:
undetectable		 1s14A-2y9yA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
(Saccharomyces
cerevisiae) 		5 / 12 SER A 881
ASP A 878
GLU A 882
PRO A 812
ARG A 936
 None
 1.43A 1s14B-2y9yA:
undetectable		 1s14B-2y9yA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B 548
GLU A 995
ARG A1035
 None
 0.72A 1wopA-2y9yB:
undetectable		 1wopA-2y9yB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 997
SER A 993
GLY A1046
ARG A1045
THR B 426
 None
 1.32A 2b8jB-2y9yA:
undetectable		 2b8jB-2y9yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 207
ASP B 199
ASP B 246
 None
 0.75A 2igtA-2y9yB:
undetectable		 2igtA-2y9yB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 207
ASP B 199
ASP B 246
 None
 0.78A 2igtB-2y9yB:
undetectable		 2igtB-2y9yB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 975
PHE A 976
HIS B 613
VAL B 615
 None
 1.02A 2lh6A-2y9yA:
undetectable		 2lh6A-2y9yA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 261
PHE B 196
GLN B 201
ASN B 190
LEU B 554
 None
 1.24A 2w3mB-2y9yB:
undetectable		 2w3mB-2y9yB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 4 GLU B 209
ASP B 633
HIS B 632
GLU B 629
 None
 1.47A 2x45A-2y9yB:
0.0		 2x45A-2y9yB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 947
PHE A 895
HIS B 346
 None
 0.76A 3h0aA-2y9yA:
undetectable		 3h0aA-2y9yA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 178
LEU B 257
LEU B 214
PHE B 205
 None
 1.17A 3nk2X-2y9yB:
undetectable		 3nk2X-2y9yB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 4 PRO B 521
LEU B 447
ILE B 451
ARG B 454
 None
 1.23A 3w1wA-2y9yB:
undetectable		 3w1wA-2y9yB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 8 ARG A1044
ARG A1037
TYR B 411
HIS B 415
 None
 1.00A 3zmdA-2y9yA:
1.4
3zmdB-2y9yA:
1.4		 3zmdA-2y9yA:
20.27
3zmdB-2y9yA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 THR B 433
GLY B 541
ARG B 553
LEU B 154
 None
 1.15A 4ac9C-2y9yB:
undetectable		 4ac9C-2y9yB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 THR B 433
GLY B 541
ARG B 553
LEU B 154
 None
 1.17A 4acaC-2y9yB:
undetectable		 4acaC-2y9yB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B 397
ARG A1035
ASP B 181
 None
 0.85A 4fp9D-2y9yB:
undetectable		 4fp9D-2y9yB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG A1037
HIS B 407
TYR A1033
 None
 1.31A 4fu8A-2y9yA:
undetectable		 4fu8A-2y9yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG A1037
HIS B 407
TYR A1033
 None
 1.34A 4fu9A-2y9yA:
undetectable		 4fu9A-2y9yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 589
GLY B 594
ILE B 716
LYS B 578
 None
 1.08A 4ma8C-2y9yB:
undetectable		 4ma8C-2y9yB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 GLU A1041
ILE B 410
HIS B 415
TYR A 992
 None
 1.26A 4qwpA-2y9yA:
undetectable		 4qwpA-2y9yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 ASN B 255
PHE B 295
LEU B 299
LEU B 302
ALA B 394
 None
 1.18A 4rtbA-2y9yB:
undetectable		 4rtbA-2y9yB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 TYR A1007
LYS A1006
LYS B 327
 None
 1.35A 5dbyA-2y9yA:
3.0		 5dbyA-2y9yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 604
LEU B 535
LEU B 540
GLY B 541
TYR B 432
 None
 1.38A 5fctA-2y9yB:
undetectable		 5fctA-2y9yB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 185
ASP B 213
ARG B 388
ASN B 255
ILE B 380
 None
 1.41A 5uh6C-2y9yB:
undetectable		 5uh6C-2y9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 185
ASP B 213
ARG B 388
ASN B 255
ILE B 380
 None
 1.40A 5uhgC-2y9yB:
undetectable		 5uhgC-2y9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 938
HIS A 807
ARG A 936
 None
 0.99A 5uunA-2y9yA:
undetectable		 5uunA-2y9yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 530
LEU B 535
THR B 148
ARG B 542
 None
 1.05A 6ew0G-2y9yB:
undetectable		 6ew0G-2y9yB:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2y9y ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 5 GLN B 428
THR B 426
THR B 608
HIS B 606
 None
 1.18A 6gbnD-2y9yB:
undetectable		 6gbnD-2y9yB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 TRP B 309
THR B 265
ARG A1035
ASP B 397
 None
 1.18A 6mn4E-2y9yB:
undetectable		 6mn4E-2y9yB:
19.54