SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ya1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 601
TRP A1002
TYR A 624
ARG A1018
 None
 1.45A 1ceaA-2ya1A:
undetectable
1ceaB-2ya1A:
undetectable		 1ceaA-2ya1A:
6.61
1ceaB-2ya1A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		6 / 12 TYR A 667
ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 BGC  A2144 (-4.5A)
None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.80A 1dedB-2ya1A:
22.3		 1dedB-2ya1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		7 / 12 TYR A 667
HIS A 715
ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 BGC  A2144 (-4.5A)
BGC  A2144 (-4.2A)
None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.58A 1mxdA-2ya1A:
19.0		 1mxdA-2ya1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 815
PHE A 732
TRP A 438
ARG A 439
 None
 1.41A 1rqpB-2ya1A:
undetectable		 1rqpB-2ya1A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 635
PHE A 693
GLU A 692
ILE A 700
 None
 0.93A 2azxA-2ya1A:
undetectable		 2azxA-2ya1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 805
ASP A 710
ASP A 778
GLU A 592
 None
None
BGC  A2144 (-2.8A)
None
 0.95A 2j2pE-2ya1A:
undetectable
2j2pF-2ya1A:
undetectable		 2j2pE-2ya1A:
11.54
2j2pF-2ya1A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 5 PHE A 303
PHE A 326
HIS A 332
VAL A 246
 None
 1.19A 2lh6A-2ya1A:
undetectable		 2lh6A-2ya1A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 815
PHE A 732
TRP A 438
ARG A 439
 None
 1.39A 2v7uB-2ya1A:
undetectable		 2v7uB-2ya1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A 335
ASN A 347
SER A 237
ASP A 353
 None
None
None
NA  A2157 (-3.9A)
 1.12A 2zw9B-2ya1A:
undetectable		 2zw9B-2ya1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.66A 3aicA-2ya1A:
8.2		 3aicA-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.65A 3aicB-2ya1A:
3.6		 3aicB-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
TYR A 667
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
BGC  A2144 (-4.5A)
 0.62A 3aicC-2ya1A:
6.1		 3aicC-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.73A 3aicD-2ya1A:
8.2		 3aicD-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
ARG A 842
HIS A 894
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
GLC  A2149 (-2.8A)
None
 0.74A 3aicE-2ya1A:
8.2		 3aicE-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.66A 3aicE-2ya1A:
8.2		 3aicE-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.66A 3aicF-2ya1A:
8.2		 3aicF-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.66A 3aicG-2ya1A:
8.2		 3aicG-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.71A 3aicH-2ya1A:
8.2		 3aicH-2ya1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 792
GLU A 586
ASP A1041
 None
 0.85A 3bxoA-2ya1A:
undetectable		 3bxoA-2ya1A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 4 GLN A1054
PRO A1052
VAL A1057
GLU A1058
 None
 1.38A 3huoA-2ya1A:
undetectable		 3huoA-2ya1A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 TRP A 168
LEU A 202
TRP A 158
ASN A 204
 GLC  A2146 (-3.6A)
None
GLC  A2147 (-3.7A)
None
 1.05A 3k8mA-2ya1A:
21.8		 3k8mA-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 7 TRP A 265
LEU A 306
TRP A 276
LYS A 318
ASN A 323
 GLC  A2159 (-3.8A)
None
GLC  A2158 (-3.6A)
GLC  A2158 (-2.8A)
GLC  A2159 (-3.1A)
 0.66A 3k8mA-2ya1A:
21.8		 3k8mA-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 TRP A 168
LEU A 202
TRP A 158
ASN A 204
 GLC  A2146 (-3.6A)
None
GLC  A2147 (-3.7A)
None
 1.05A 3k8mB-2ya1A:
0.0		 3k8mB-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 7 TRP A 265
LEU A 306
TRP A 276
LYS A 318
ASN A 323
 GLC  A2159 (-3.8A)
None
GLC  A2158 (-3.6A)
GLC  A2158 (-2.8A)
GLC  A2159 (-3.1A)
 0.64A 3k8mB-2ya1A:
0.0		 3k8mB-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A 788
PHE A 777
ASP A 778
GLU A 807
 None
None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
 1.18A 3kp6A-2ya1A:
undetectable
3kp6B-2ya1A:
undetectable		 3kp6A-2ya1A:
10.21
3kp6B-2ya1A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 882
ASP A 886
PRO A 884
GLN A 935
 None
 1.16A 3l2vA-2ya1A:
1.8		 3l2vA-2ya1A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 GLN A 935
LEU A1104
ARG A1035
PHE A1034
 None
None
NA  A2156 (-4.0A)
None
 0.94A 3ln1C-2ya1A:
undetectable		 3ln1C-2ya1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 948
GLY A 947
ASN A1014
ASN A 928
TYR A 591
 None
 1.09A 3mekA-2ya1A:
undetectable		 3mekA-2ya1A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 994
SER A 993
HIS A 594
 None
 0.81A 3mzeA-2ya1A:
undetectable		 3mzeA-2ya1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 948
GLY A 947
ASN A1014
ASN A 928
TYR A 591
 None
 1.08A 3qwpA-2ya1A:
undetectable		 3qwpA-2ya1A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 THR A 751
GLY A 749
TYR A 812
GLY A 781
 None
 0.83A 3tajA-2ya1A:
undetectable		 3tajA-2ya1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 709
VAL A 772
LEU A 696
ILE A 697
PHE A 615
 None
 0.97A 3tbgD-2ya1A:
undetectable		 3tbgD-2ya1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 HIS A 941
TYR A 946
GLY A 943
SER A 942
GLY A 613
 NA  A2153 (-4.3A)
None
None
None
None
 1.23A 4blvB-2ya1A:
undetectable		 4blvB-2ya1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A1077
LEU A1091
LEU A1098
GLY A1127
LEU A1130
 None
 1.11A 4dm8B-2ya1A:
undetectable		 4dm8B-2ya1A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 THR A 751
GLY A 749
TYR A 812
GLY A 781
 None
 0.81A 4fjpA-2ya1A:
undetectable		 4fjpA-2ya1A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 THR A 751
GLY A 749
TYR A 812
GLY A 781
 None
 0.84A 4forA-2ya1A:
undetectable		 4forA-2ya1A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A 291
ARG A 247
ASP A 181
GLU A 226
 None
 1.31A 4kr4C-2ya1A:
undetectable		 4kr4C-2ya1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 11 PHE A 837
GLY A 808
LEU A 805
ILE A 700
LEU A 622
 None
 1.12A 4kt0A-2ya1A:
undetectable
4kt0J-2ya1A:
undetectable		 4kt0A-2ya1A:
21.26
4kt0J-2ya1A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 VAL A1103
LEU A1138
ILE A1049
THR A1124
 None
 0.83A 4ma7A-2ya1A:
undetectable		 4ma7A-2ya1A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A 453
ILE A 513
GLY A 518
ALA A 562
VAL A 478
 None
SO4  A2152 (-4.4A)
None
None
None
 1.10A 4r1zA-2ya1A:
undetectable		 4r1zA-2ya1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A 667
TRP A 665
HIS A 594
PHE A 939
 BGC  A2144 (-4.5A)
None
None
None
 1.13A 4tzcB-2ya1A:
undetectable
4tzcD-2ya1A:
undetectable		 4tzcB-2ya1A:
6.68
4tzcD-2ya1A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 948
GLY A 947
ASN A1014
ASN A 928
TYR A 591
 None
 1.07A 5ccmA-2ya1A:
undetectable		 5ccmA-2ya1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 776
ASP A 778
GLU A 807
HIS A 894
ASP A 895
 None
BGC  A2144 (-2.8A)
GLC  A2150 ( 4.5A)
None
GLC  A2150 ( 4.3A)
 0.34A 5csyB-2ya1A:
16.3		 5csyB-2ya1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 817
ASP A 736
GLY A 737
 None
 0.62A 5fctB-2ya1A:
undetectable		 5fctB-2ya1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 SER A 600
ASP A 995
TYR A 656
SER A 661
 None
 1.13A 5l1fA-2ya1A:
undetectable
5l1fB-2ya1A:
undetectable		 5l1fA-2ya1A:
22.94
5l1fB-2ya1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A1066
GLY A1065
VAL A 865
PHE A 857
ALA A1135
 None
 1.20A 5n0rA-2ya1A:
undetectable		 5n0rA-2ya1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 262
SER A 261
PHE A 282
ASP A 281
 None
 1.19A 5om3A-2ya1A:
undetectable
5om3B-2ya1A:
undetectable		 5om3A-2ya1A:
6.45
5om3B-2ya1A:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 4 ASP A 995
SER A 600
ASP A 597
HIS A 594
 None
 1.48A 5wyqB-2ya1A:
undetectable		 5wyqB-2ya1A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 948
GLY A 947
ASN A1014
ASN A 928
TYR A 591
 None
 1.05A 5xxjA-2ya1A:
undetectable		 5xxjA-2ya1A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 667
HIS A 715
ASP A 778
HIS A 894
ASP A 895
 BGC  A2144 (-4.5A)
BGC  A2144 (-4.2A)
BGC  A2144 (-2.8A)
None
GLC  A2150 ( 4.3A)
 0.51A 6ag0A-2ya1A:
18.2		 6ag0A-2ya1A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 MET A1021
GLY A 943
ALA A 892
LEU A 899
 None
None
NA  A2153 ( 3.8A)
NA  A2153 (-4.9A)
 0.97A 6fosA-2ya1A:
undetectable		 6fosA-2ya1A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 709
LEU A 802
GLY A 706
HIS A 701
PHE A 693
 None
 1.42A 6gbnB-2ya1A:
undetectable		 6gbnB-2ya1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 HIS A 988
HIS A 594
ASP A 895
GLU A 807
 None
None
GLC  A2150 ( 4.3A)
GLC  A2150 ( 4.5A)
 1.12A 6mn4C-2ya1A:
undetectable		 6mn4C-2ya1A:
13.78