SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ya2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 146
TRP A 547
TYR A 169
ARG A 563
 None
 1.43A 1ceaA-2ya2A:
undetectable
1ceaB-2ya2A:
undetectable		 1ceaA-2ya2A:
8.33
1ceaB-2ya2A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 546
TRP A 547
TYR A 169
ARG A 563
 None
 1.49A 1cebA-2ya2A:
undetectable		 1cebA-2ya2A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		6 / 12 TYR A 212
ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 ( 3.9A)
NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.88A 1dedB-2ya2A:
22.4		 1dedB-2ya2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		8 / 12 TYR A 212
HIS A 260
PHE A 288
ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 ( 3.9A)
NOJ  A1689 (-4.5A)
NOJ  A1689 (-3.5A)
NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.83A 1mxdA-2ya2A:
20.2		 1mxdA-2ya2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 162
ILE A 164
VAL A 140
LEU A 254
ILE A 178
 None
 1.09A 2h42B-2ya2A:
undetectable		 2h42B-2ya2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 350
ASP A 255
ASP A 323
GLU A 137
 None
None
NOJ  A1689 (-2.8A)
None
 0.93A 2j2pE-2ya2A:
undetectable
2j2pF-2ya2A:
undetectable		 2j2pE-2ya2A:
14.81
2j2pF-2ya2A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.65A 3aicA-2ya2A:
4.7		 3aicA-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.65A 3aicB-2ya2A:
3.4		 3aicB-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
TYR A 212
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
NOJ  A1689 ( 3.9A)
 0.62A 3aicC-2ya2A:
3.8		 3aicC-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.72A 3aicD-2ya2A:
5.5		 3aicD-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.67A 3aicE-2ya2A:
6.2		 3aicE-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.66A 3aicF-2ya2A:
3.8		 3aicF-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.65A 3aicG-2ya2A:
5.8		 3aicG-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.70A 3aicH-2ya2A:
4.0		 3aicH-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 337
GLU A 131
ASP A 586
 None
 0.81A 3bxoA-2ya2A:
undetectable		 3bxoA-2ya2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A 333
PHE A 322
ASP A 323
GLU A 352
 None
None
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
 1.18A 3kp6A-2ya2A:
undetectable
3kp6B-2ya2A:
undetectable		 3kp6A-2ya2A:
12.09
3kp6B-2ya2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 427
ASP A 431
PRO A 429
GLN A 480
 CA  A1691 (-2.8A)
CA  A1691 (-2.2A)
None
None
 1.12A 3l2vA-2ya2A:
undetectable		 3l2vA-2ya2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 GLN A 480
LEU A 649
ARG A 580
PHE A 579
 None
 0.94A 3ln1C-2ya2A:
undetectable		 3ln1C-2ya2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 493
GLY A 492
ASN A 559
ASN A 473
TYR A 136
 None
 1.01A 3mekA-2ya2A:
undetectable		 3mekA-2ya2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 539
SER A 538
HIS A 139
 None
 0.80A 3mzeA-2ya2A:
undetectable		 3mzeA-2ya2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 493
GLY A 492
ASN A 559
ASN A 473
TYR A 136
 None
 1.00A 3qwpA-2ya2A:
undetectable		 3qwpA-2ya2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 THR A 296
GLY A 294
TYR A 357
GLY A 326
 None
 0.84A 3tajA-2ya2A:
undetectable		 3tajA-2ya2A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 254
VAL A 317
LEU A 241
ILE A 242
PHE A 160
 None
 0.97A 3tbgD-2ya2A:
undetectable		 3tbgD-2ya2A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 472
ARG A 408
ILE A 436
LEU A 469
 None
 1.24A 4acaC-2ya2A:
undetectable		 4acaC-2ya2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 622
LEU A 636
LEU A 643
GLY A 672
LEU A 675
 None
 1.11A 4dm8B-2ya2A:
undetectable		 4dm8B-2ya2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 THR A 296
GLY A 294
TYR A 357
GLY A 326
 None
 0.82A 4fjpA-2ya2A:
undetectable		 4fjpA-2ya2A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 THR A 296
GLY A 294
TYR A 357
GLY A 326
 None
 0.84A 4forA-2ya2A:
undetectable		 4forA-2ya2A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 VAL A 648
LEU A 683
ILE A 594
THR A 669
 None
 0.89A 4ma7A-2ya2A:
undetectable		 4ma7A-2ya2A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 602
GLU A 603
VAL A 607
LYS A 407
 None
 1.20A 4p6vB-2ya2A:
undetectable
4p6vE-2ya2A:
undetectable		 4p6vB-2ya2A:
19.72
4p6vE-2ya2A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A  -2
ILE A  58
GLY A  63
ALA A 107
VAL A  23
 None
 1.08A 4r1zA-2ya2A:
undetectable		 4r1zA-2ya2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 673
GLY A 672
GLU A 633
GLU A 670
 None
 0.74A 4rjdA-2ya2A:
undetectable
4rjdB-2ya2A:
undetectable		 4rjdA-2ya2A:
6.64
4rjdB-2ya2A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A 212
TRP A 210
HIS A 139
PHE A 484
 NOJ  A1689 ( 3.9A)
None
None
None
 1.15A 4tzcB-2ya2A:
undetectable
4tzcD-2ya2A:
undetectable		 4tzcB-2ya2A:
9.43
4tzcD-2ya2A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A  91
PHE A 188
TYR A 186
 None
 0.84A 4u15A-2ya2A:
undetectable		 4u15A-2ya2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 493
GLY A 492
ASN A 559
ASN A 473
TYR A 136
 None
 0.99A 5ccmA-2ya2A:
0.0		 5ccmA-2ya2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.29A 5csyB-2ya2A:
14.8		 5csyB-2ya2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 362
ASP A 281
GLY A 282
 None
 0.50A 5fctB-2ya2A:
undetectable		 5fctB-2ya2A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 611
GLY A 610
VAL A 410
PHE A 402
ALA A 680
 None
 1.16A 5n0oA-2ya2A:
undetectable		 5n0oA-2ya2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 611
GLY A 610
VAL A 410
PHE A 402
ALA A 680
 None
 1.16A 5n0rA-2ya2A:
undetectable		 5n0rA-2ya2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 611
GLY A 610
VAL A 410
PHE A 402
ALA A 680
 None
 1.19A 5n0wA-2ya2A:
undetectable		 5n0wA-2ya2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 4 ASP A 540
SER A 145
ASP A 142
HIS A 139
 None
 1.45A 5wyqB-2ya2A:
0.3		 5wyqB-2ya2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 320
LEU A 350
GLY A 351
PHE A 322
 None
 0.89A 5x5qC-2ya2A:
undetectable		 5x5qC-2ya2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 320
LEU A 350
GLY A 351
PHE A 322
 None
 0.88A 5x5qF-2ya2A:
undetectable		 5x5qF-2ya2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 493
GLY A 492
ASN A 559
ASN A 473
TYR A 136
 None
 1.02A 5xxgA-2ya2A:
undetectable		 5xxgA-2ya2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 493
GLY A 492
ASN A 559
ASN A 473
TYR A 136
 None
 0.98A 5xxjA-2ya2A:
undetectable		 5xxjA-2ya2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 212
HIS A 260
ASP A 323
HIS A 439
ASP A 440
 NOJ  A1689 ( 3.9A)
NOJ  A1689 (-4.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.52A 6ag0A-2ya2A:
17.2		 6ag0A-2ya2A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 MET A 566
GLY A 488
ALA A 437
LEU A 444
 None
 1.03A 6fosA-2ya2A:
undetectable		 6fosA-2ya2A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A 242
LEU A 241
LEU A 180
LEU A 170
 None
 0.73A 6g9bA-2ya2A:
undetectable
6g9bB-2ya2A:
undetectable		 6g9bA-2ya2A:
7.56
6g9bB-2ya2A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 254
LEU A 347
GLY A 251
HIS A 246
PHE A 238
 None
 1.39A 6gbnB-2ya2A:
undetectable		 6gbnB-2ya2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 HIS A 533
HIS A 139
ASP A 440
GLU A 352
 None
None
NOJ  A1689 (-2.9A)
NOJ  A1689 (-3.0A)
 1.05A 6mn4C-2ya2A:
undetectable		 6mn4C-2ya2A:
16.13