SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ya3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 7 VAL A 427
CYH A 539
ARG A 436
CYH A 414
 None
 1.26A 1t46A-2ya3A:
undetectable		 1t46A-2ya3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 4 LEU A 461
SER A 402
TYR A 459
LEU A 451
 None
 1.28A 1xz1A-2ya3A:
undetectable		 1xz1A-2ya3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 4 LEU A 461
SER A 402
TYR A 459
LEU A 451
 None
 1.28A 1xz3A-2ya3A:
undetectable		 1xz3A-2ya3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 SER A 404
ASP A 408
PRO A 406
SER A 402
 None
 1.37A 2hdnA-2ya3A:
undetectable
2hdnB-2ya3A:
undetectable
2hdnD-2ya3A:
undetectable		 2hdnA-2ya3A:
10.00
2hdnB-2ya3A:
20.18
2hdnD-2ya3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 SER A 402
SER A 404
ASP A 408
PRO A 406
 None
 1.37A 2hdnB-2ya3A:
undetectable
2hdnC-2ya3A:
undetectable
2hdnD-2ya3A:
undetectable		 2hdnB-2ya3A:
20.18
2hdnC-2ya3A:
10.00
2hdnD-2ya3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 12 PHE A 536
CYH A 539
ILE A 400
LEU A 449
VAL A 434
 None
 1.25A 3sp9A-2ya3A:
undetectable		 3sp9A-2ya3A:
23.16