SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
AMP  A1302 ( 4.8A)
AMP  A1302 (-3.1A)
 0.62A 1fmoE-2yabA:
22.2		 1fmoE-2yabA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 LEU A 105
PHE A 296
LEU A 111
ILE A 145
TRP A 274
 None
 1.37A 1hrkB-2yabA:
undetectable		 1hrkB-2yabA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.81A 1m17A-2yabA:
21.5		 1m17A-2yabA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.6A)
None
None
None
None
 0.45A 1uwhA-2yabA:
24.0		 1uwhA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
None
 0.48A 1uwhB-2yabA:
23.8		 1uwhB-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
None
 0.57A 1uwjA-2yabA:
6.7		 1uwjA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 7 LYS A  42
LEU A  68
ILE A  76
ILE A 135
 AMP  A1302 (-2.8A)
None
None
None
 0.49A 1uwjA-2yabA:
6.7		 1uwjA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 9 LEU A  19
VAL A  27
LEU A  79
LEU A  91
LEU A  95
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
None
None
AMP  A1302 ( 4.9A)
 0.55A 1xkkA-2yabA:
23.1		 1xkkA-2yabA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 9 VAL A  27
LYS A  42
LEU A  79
LEU A  91
LEU A  95
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.75A 1xkkA-2yabA:
23.1		 1xkkA-2yabA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 10 LEU A  19
ALA A  40
ILE A  77
LEU A  93
ILE A 160
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 3.6A)
AMP  A1302 (-4.0A)
 0.70A 1yi4A-2yabA:
27.3		 1yi4A-2yabA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		9 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASP A 139
LYS A 141
ASN A 144
MET A 146
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
None
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
 0.71A 2fumA-2yabA:
27.1		 2fumA-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		9 / 12 LEU A  19
VAL A  27
ALA A  40
VAL A  96
ASP A 139
LYS A 141
ASN A 144
MET A 146
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
None
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-3.1A)
 0.72A 2fumA-2yabA:
27.1		 2fumA-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		8 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
MET A 146
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
 0.69A 2fumB-2yabA:
27.2		 2fumB-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		8 / 12 LEU A  19
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
MET A 146
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-3.1A)
 0.77A 2fumB-2yabA:
27.2		 2fumB-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
 0.80A 2fumC-2yabA:
25.5		 2fumC-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		8 / 12 LEU A  19
GLY A  20
GLY A  22
VAL A  27
ALA A  40
LYS A 141
ASN A 144
MET A 146
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 ( 4.6A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
 0.82A 2fumD-2yabA:
25.6		 2fumD-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
None
 0.70A 2ivuA-2yabA:
26.5		 2ivuA-2yabA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 ILE A 120
ILE A 252
ALA A 248
THR A 244
VAL A 291
 None
 1.17A 3a51E-2yabA:
undetectable		 3a51E-2yabA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
AMP  A1302 (-3.1A)
 1.16A 3gp0A-2yabA:
22.6		 3gp0A-2yabA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
 0.60A 3gp0A-2yabA:
22.6		 3gp0A-2yabA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 3.8A)
 0.64A 3hecA-2yabA:
22.3		 3hecA-2yabA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.56A 3hecA-2yabA:
22.3		 3hecA-2yabA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 ( 3.8A)
 0.74A 3hegA-2yabA:
22.1		 3hegA-2yabA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 9 ALA A 269
LEU A 255
VAL A 127
ILE A 206
ILE A 123
 None
 1.10A 3jw3B-2yabA:
undetectable		 3jw3B-2yabA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 8 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.50A 3lfaA-2yabA:
21.8		 3lfaA-2yabA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
 AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 ( 3.8A)
 0.71A 3ohtA-2yabA:
3.7		 3ohtA-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		3 / 3 GLU A  64
LEU A  91
LEU A  95
 None
None
AMP  A1302 ( 4.9A)
 0.53A 3ohtA-2yabA:
5.5		 3ohtA-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
 AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
 0.46A 3ohtB-2yabA:
5.5		 3ohtB-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		3 / 3 GLU A  64
LEU A  91
LEU A  95
 None
None
AMP  A1302 ( 4.9A)
 0.52A 3ohtB-2yabA:
5.5		 3ohtB-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
None
 0.61A 3rgfA-2yabA:
17.8		 3rgfA-2yabA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 8 LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.71A 3warA-2yabA:
27.4		 3warA-2yabA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.68A 3warA-2yabA:
27.4		 3warA-2yabA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
None
None
 0.59A 3wzeA-2yabA:
22.4		 3wzeA-2yabA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
 0.48A 3wzeA-2yabA:
22.4		 3wzeA-2yabA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
LYS A  42
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
None
None
 0.72A 3wzeA-2yabA:
22.4		 3wzeA-2yabA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.60A 4agcA-2yabA:
21.9		 4agcA-2yabA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		9 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
None
None
 0.72A 4asdA-2yabA:
5.7		 4asdA-2yabA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 ALA A  25
SER A  21
VAL A  27
ILE A 160
ASN A 144
 AMP  A1302 (-3.6A)
None
AMP  A1302 (-4.2A)
AMP  A1302 (-4.0A)
AMP  A1302 ( 4.8A)
 1.12A 4c49A-2yabA:
undetectable		 4c49A-2yabA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 11 VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLU A 143
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
None
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.61A 4iaaA-2yabA:
27.2		 4iaaA-2yabA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 8 GLY A  22
VAL A  27
ALA A  40
LYS A  42
 AMP  A1302 ( 4.6A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
 0.23A 4l9iB-2yabA:
20.4		 4l9iB-2yabA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.64A 4mkcA-2yabA:
25.4		 4mkcA-2yabA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
LYS A  42
LEU A  93
LEU A  95
GLY A  99
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
AMP  A1302 ( 4.9A)
None
AMP  A1302 (-3.1A)
 0.85A 4mkcA-2yabA:
25.4		 4mkcA-2yabA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
 0.17A 4o0wA-2yabA:
28.6		 4o0wA-2yabA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 MET A 200
ILE A 203
ALA A 269
GLN A 267
LEU A 196
 None
 0.98A 4qzuC-2yabA:
undetectable		 4qzuC-2yabA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 10 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.9A)
 0.59A 4rz7A-2yabA:
10.8		 4rz7A-2yabA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 6 LEU A  19
VAL A  27
LYS A  42
ILE A  76
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
 0.62A 4tyjA-2yabA:
22.6		 4tyjA-2yabA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.46A 4wkqA-2yabA:
25.5		 4wkqA-2yabA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 (-3.1A)
None
 0.81A 4xv2B-2yabA:
24.2		 4xv2B-2yabA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.79A 5cswA-2yabA:
24.1		 5cswA-2yabA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.86A 5cswB-2yabA:
24.1		 5cswB-2yabA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		3 / 3 ASN A 144
LEU A  68
PHE A 138
 AMP  A1302 ( 4.8A)
None
None
 0.78A 5dsgA-2yabA:
undetectable		 5dsgA-2yabA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
None
 0.59A 5hi2A-2yabA:
24.5		 5hi2A-2yabA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 VAL A   9
ALA A  40
ALA A  41
VAL A  90
LEU A  93
 None
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.6A)
 1.45A 5igpA-2yabA:
7.2		 5igpA-2yabA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 AMP  A1302 (-3.5A)
AMP  A1302 ( 4.6A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
 0.47A 5izjA-2yabA:
28.0		 5izjA-2yabA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 11 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 143
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.6A)
None
 0.37A 5lvnA-2yabA:
23.7		 5lvnA-2yabA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 10 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.9A)
 0.43A 5lw1E-2yabA:
22.9		 5lw1E-2yabA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		8 / 12 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLY A  99
GLU A 100
ILE A 160
 None
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.6A)
None
None
AMP  A1302 (-4.0A)
 0.98A 5mafA-2yabA:
29.1		 5mafA-2yabA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		8 / 12 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
GLY A  99
 None
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 ( 3.6A)
None
 0.83A 5mafA-2yabA:
29.1		 5mafA-2yabA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		8 / 12 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
ILE A 160
 None
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
None
AMP  A1302 (-4.0A)
 0.87A 5mafA-2yabA:
29.1		 5mafA-2yabA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 10 LEU A  19
VAL A  27
LYS A  42
GLU A  64
GLY A  99
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
 0.63A 5mo4A-2yabA:
20.3		 5mo4A-2yabA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.44A 5vcvA-2yabA:
25.4		 5vcvA-2yabA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
GLY A  98
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
 0.92A 5vcyA-2yabA:
25.5		 5vcyA-2yabA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 7 LEU A 159
ASP A 199
TRP A 274
HIS A 272
 None
 1.16A 5w97C-2yabA:
undetectable
5w97a-2yabA:
1.8
5w97c-2yabA:
undetectable		 5w97C-2yabA:
19.28
5w97a-2yabA:
20.30
5w97c-2yabA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.76A 5y7zB-2yabA:
27.0		 5y7zB-2yabA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.55A 5y80A-2yabA:
26.1		 5y80A-2yabA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 8 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.65A 5y9mA-2yabA:
27.1		 5y9mA-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.71A 5y9mA-2yabA:
27.1		 5y9mA-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		4 / 8 LEU A  19
VAL A  27
LYS A  42
ILE A 160
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 (-4.0A)
 0.62A 5y9mX-2yabA:
27.1		 5y9mX-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.72A 5y9mX-2yabA:
27.1		 5y9mX-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 7 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.87A 5yf9B-2yabA:
27.0		 5yf9B-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.79A 5yf9X-2yabA:
27.5		 5yf9X-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 9 VAL A  27
LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.93A 5yf9X-2yabA:
27.5		 5yf9X-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		5 / 7 VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.55A 5ywmX-2yabA:
27.3		 5ywmX-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		3 / 3 ALA A  40
VAL A   9
TYR A  13
 AMP  A1302 (-3.6A)
None
None
 0.62A 5zmqH-2yabA:
undetectable		 5zmqH-2yabA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.51A 5zv2B-2yabA:
22.6		 5zv2B-2yabA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yab DEATH-ASSOCIATED
PROTEIN KINASE 2
(Mus
musculus) 		3 / 3 LEU A 264
GLY A 204
PHE A 236
 None
 0.53A 6exiC-2yabA:
undetectable		 6exiC-2yabA:
13.03