SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		5 / 11 PHE B  54
LEU B  52
ALA B 162
TYR B 289
HIS B 166
 None
 1.30A 1qabE-2yaxB:
0.0		 1qabE-2yaxB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		5 / 11 LEU B  97
VAL B  30
ASN B  45
ILE B 207
MET B 210
 None
 1.21A 2uxoB-2yaxB:
undetectable		 2uxoB-2yaxB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		3 / 3 LEU B 293
ARG B  73
ILE B 292
 None
 0.67A 2xn5B-2yaxB:
undetectable		 2xn5B-2yaxB:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		3 / 3 PRO B   4
PHE B  40
LYS B  81
 None
 1.21A 3bjwG-2yaxB:
undetectable		 3bjwG-2yaxB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		4 / 6 GLN B 107
PRO B  17
PHE B  20
PHE B  23
 None
 0.97A 4fgkA-2yaxB:
undetectable		 4fgkA-2yaxB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		4 / 5 TYR B  77
LEU B 306
GLU B 253
VAL B 151
 None
 1.05A 4nkvA-2yaxB:
undetectable		 4nkvA-2yaxB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2yax SULFUR
OXYGENASE/REDUCTASE
(Acidianus
ambivalens) 		4 / 6 TYR B  77
LEU B 306
GLU B 253
VAL B 151
 None
 1.02A 4nkvC-2yaxB:
undetectable		 4nkvC-2yaxB:
22.47