SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ybq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 180
THR A 156
SER A 154
TRP A 172
 None
 1.35A 1eiiA-2ybqA:
undetectable		 1eiiA-2ybqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A  34
LEU A  32
GLY A  26
LEU A  57
 None
 1.03A 1gtiE-2ybqA:
undetectable		 1gtiE-2ybqA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.41A 1l7fA-2ybqA:
undetectable		 1l7fA-2ybqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.44A 1l7hA-2ybqA:
undetectable		 1l7hA-2ybqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.06A 1v54A-2ybqA:
undetectable
1v54J-2ybqA:
undetectable		 1v54A-2ybqA:
21.48
1v54J-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  38
LEU A  40
LYS A  13
 None
 1.48A 1yajK-2ybqA:
undetectable		 1yajK-2ybqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.08A 2eijA-2ybqA:
undetectable
2eijJ-2ybqA:
undetectable		 2eijA-2ybqA:
21.48
2eijJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.06A 2eilA-2ybqA:
undetectable
2eilJ-2ybqA:
undetectable		 2eilA-2ybqA:
21.48
2eilJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  40
ALA A  44
LEU A  61
LEU A 101
VAL A  23
 None
 1.15A 2w9gA-2ybqA:
undetectable		 2w9gA-2ybqA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.06A 3ablA-2ybqA:
undetectable
3ablJ-2ybqA:
undetectable		 3ablA-2ybqA:
21.48
3ablJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.02A 3abmA-2ybqA:
undetectable
3abmJ-2ybqA:
undetectable		 3abmA-2ybqA:
21.48
3abmJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.08A 3asoA-2ybqA:
undetectable
3asoJ-2ybqA:
undetectable		 3asoA-2ybqA:
21.48
3asoJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  40
ALA A  44
LEU A  61
LEU A 101
VAL A  23
 None
 1.08A 3frbX-2ybqA:
3.8		 3frbX-2ybqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  34
GLY A 104
GLY A 131
LEU A  32
VAL A  53
 None
SAH  A1267 (-3.5A)
None
None
None
 1.12A 3fzgA-2ybqA:
undetectable		 3fzgA-2ybqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.29A 3mecA-2ybqA:
undetectable		 3mecA-2ybqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 247
LEU A 182
ILE A 194
ALA A 195
 None
 0.88A 3n8yB-2ybqA:
undetectable		 3n8yB-2ybqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 157
SER A 139
SER A 136
 None
 0.91A 3ufgB-2ybqA:
undetectable		 3ufgB-2ybqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.25A 4mwrA-2ybqA:
undetectable		 4mwrA-2ybqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.39A 4mwvA-2ybqA:
undetectable		 4mwvA-2ybqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.23A 4mwxA-2ybqA:
undetectable		 4mwxA-2ybqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.41A 4mx0A-2ybqA:
undetectable		 4mx0A-2ybqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  50
LEU A  41
GLY A 103
LEU A  57
GLY A 112
 UP2  A1268 (-3.6A)
None
SAH  A1267 (-4.8A)
None
None
 0.93A 4n09C-2ybqA:
undetectable		 4n09C-2ybqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  57
VAL A  23
VAL A  47
TRP A  38
 None
 1.03A 4puoC-2ybqA:
undetectable		 4puoC-2ybqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.19A 5cymA-2ybqA:
undetectable		 5cymA-2ybqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.20A 5cyqA-2ybqA:
undetectable		 5cyqA-2ybqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.25A 5l17A-2ybqA:
undetectable		 5l17A-2ybqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 194
ALA A 210
VAL A 247
ILE A 245
PRO A 231
 None
 1.19A 5mlmA-2ybqA:
undetectable		 5mlmA-2ybqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 1.06A 5x1fA-2ybqA:
undetectable
5x1fJ-2ybqA:
undetectable		 5x1fA-2ybqA:
21.48
5x1fJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  61
ARG A  36
THR A  34
LEU A  33
 None
 0.96A 5xdxA-2ybqA:
undetectable
5xdxJ-2ybqA:
undetectable		 5xdxA-2ybqA:
21.48
5xdxJ-2ybqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 214
GLY A 219
ILE A  58
LEU A  57
GLY A  28
 None
 1.07A 6c2mA-2ybqA:
undetectable		 6c2mA-2ybqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 134
GLY A  24
GLY A 103
ARG A 100
VAL A 132
 SAH  A1267 (-3.2A)
None
SAH  A1267 (-4.8A)
None
None
 1.25A 6clxA-2ybqA:
2.4		 6clxA-2ybqA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.15A 6eliA-2ybqA:
undetectable		 6eliA-2ybqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 212
LEU A 244
GLY A 143
GLY A 225
ARG A 224
 None
SAH  A1267 (-3.9A)
None
None
None
 1.21A 6eu9B-2ybqA:
undetectable		 6eu9B-2ybqA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2ybq METHYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  25
GLY A 103
LEU A  52
GLY A 137
 None
SAH  A1267 (-4.8A)
UP2  A1268 ( 4.0A)
None
 0.81A 6nm4A-2ybqA:
undetectable		 6nm4A-2ybqA:
18.88