SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ybu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		6 / 9 TYR A  27
PHE A  58
GLY A  98
ASP A 138
ASP A 213
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 ( 4.4A)
CX9  A1398 ( 3.3A)
 0.89A 1e9lA-2ybuA:
61.2		 1e9lA-2ybuA:
67.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 9 TYR A  27
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
ASP A 213
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
 0.69A 1e9lA-2ybuA:
61.2		 1e9lA-2ybuA:
67.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 GLU A 169
ILE A 124
LEU A 135
GLY A 134
ALA A  59
 None
 1.16A 1hvyA-2ybuA:
undetectable		 1hvyA-2ybuA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 9 PHE A 119
GLY A  60
ALA A  59
LEU A 135
PHE A 137
 None
 1.16A 1nr6A-2ybuA:
undetectable		 1nr6A-2ybuA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 11 PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.78A 2a3aA-2ybuA:
11.5		 2a3aA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		10 / 11 TYR A  27
PHE A  58
GLY A  98
TRP A  99
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1399 ( 3.4A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.67A 2a3aA-2ybuA:
11.5		 2a3aA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 TRP A  99
GLU A 140
TYR A 141
 CX9  A1399 ( 3.4A)
CX9  A1398 (-3.7A)
None
 0.56A 2a3aA-2ybuA:
11.5		 2a3aA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_B_TEPB2433_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 9 PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.44A 2a3aB-2ybuA:
44.5		 2a3aB-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 11 PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.84A 2a3bA-2ybuA:
44.5		 2a3bA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 11 TYR A  27
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.84A 2a3bA-2ybuA:
44.5		 2a3bA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 11 TYR A  27
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.51A 2a3bA-2ybuA:
44.5		 2a3bA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 10 PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 1.01A 2a3bB-2ybuA:
11.4		 2a3bB-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 10 PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.81A 2a3bB-2ybuA:
11.4		 2a3bB-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 10 PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.32A 2a3bB-2ybuA:
11.4		 2a3bB-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 12 TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 1.07A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 12 TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.86A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 12 TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
 None
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.91A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		9 / 12 TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.59A 2a3cA-2ybuA:
11.6		 2a3cA-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 12 TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 1.03A 2a3cB-2ybuA:
44.6		 2a3cB-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 12 TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
 0.84A 2a3cB-2ybuA:
44.6		 2a3cB-2ybuA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		8 / 12 TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.43A 2a3cB-2ybuA:
44.6		 2a3cB-2ybuA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		4 / 8 SER A 341
ALA A 357
LEU A 387
ASP A 365
 None
 1.15A 2bxkA-2ybuA:
undetectable		 2bxkA-2ybuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 PHE A 119
LEU A 127
LEU A  94
ALA A  95
ILE A  96
 None
 1.12A 2bxpA-2ybuA:
undetectable		 2bxpA-2ybuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		4 / 7 VAL A 243
SER A 226
LEU A 349
PHE A 342
 None
 1.11A 2f78A-2ybuA:
undetectable		 2f78A-2ybuA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		4 / 6 TRP A 250
TYR A 195
GLN A 192
ILE A 191
 None
 1.42A 2pgzD-2ybuA:
undetectable
2pgzE-2ybuA:
undetectable		 2pgzD-2ybuA:
20.74
2pgzE-2ybuA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 9 TYR A  27
PHE A  58
GLY A  98
ASP A 138
GLU A 140
TYR A 212
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.53A 2uy4A-2ybuA:
19.9		 2uy4A-2ybuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 10 ALA A 183
ASP A 136
LEU A  93
ILE A  55
TYR A 212
 CX9  A1398 ( 4.6A)
None
None
None
CX9  A1398 (-4.3A)
 1.17A 2w9sD-2ybuA:
undetectable		 2w9sD-2ybuA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 11 TYR A  27
PHE A  58
GLY A  98
ASP A 138
GLU A 140
TYR A 212
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.79A 2xtkA-2ybuA:
20.9		 2xtkA-2ybuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 10 TYR A  27
PHE A  58
GLY A  98
ASP A 138
GLU A 140
TYR A 212
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
 0.69A 2xtkB-2ybuA:
20.8		 2xtkB-2ybuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 GLY A 194
ALA A 255
ILE A 207
LEU A 204
VAL A 159
 None
 1.00A 3adxB-2ybuA:
undetectable		 3adxB-2ybuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		4 / 5 GLN A 374
ASP A 365
ASP A 337
THR A 382
 None
 1.28A 3bwcB-2ybuA:
0.1		 3bwcB-2ybuA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA1_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		9 / 11 PHE A  58
GLY A  98
TRP A  99
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1399 ( 3.4A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.63A 3g6mA-2ybuA:
44.5		 3g6mA-2ybuA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA1_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		6 / 11 TYR A  27
PHE A  58
GLY A  98
ASP A 138
TYR A 212
TYR A 267
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-4.3A)
None
 1.00A 3g6mA-2ybuA:
44.5		 3g6mA-2ybuA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA1_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		9 / 11 TYR A  27
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 None
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.59A 3g6mA-2ybuA:
44.5		 3g6mA-2ybuA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA427_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 5 TRP A  99
TYR A 141
MET A 210
ASP A 213
TRP A 218
 CX9  A1399 ( 3.4A)
None
CX9  A1398 (-3.3A)
CX9  A1398 ( 4.4A)
CX9  A1399 (-3.3A)
 0.73A 3g6mA-2ybuA:
44.6		 3g6mA-2ybuA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 SER A 217
GLY A 287
SER A 298
 None
 0.65A 3loqA-2ybuA:
undetectable		 3loqA-2ybuA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQV_A_GCSA501_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		10 / 11 PHE A  58
GLY A  98
TRP A  99
ASP A 138
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1399 ( 3.4A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.40A 3wqvA-2ybuA:
55.9		 3wqvA-2ybuA:
43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQW_A_GCSA501_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		10 / 11 PHE A  58
GLY A  98
TRP A  99
ASP A 138
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1399 ( 3.4A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
 0.43A 3wqwA-2ybuA:
55.8		 3wqwA-2ybuA:
43.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 PHE A 126
LEU A 135
GLY A 134
PHE A 132
ALA A 182
 None
 1.27A 4eb4A-2ybuA:
undetectable		 4eb4A-2ybuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 PHE A 126
LEU A 135
GLY A 134
PHE A 132
ALA A 182
 None
 1.28A 4eb4B-2ybuA:
undetectable		 4eb4B-2ybuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 PHE A 367
TYR A 294
TYR A 304
 None
 1.09A 4ffwA-2ybuA:
undetectable		 4ffwA-2ybuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 GLU A 169
ILE A 124
LEU A 135
GLY A 134
PHE A 166
 None
 1.34A 4foxE-2ybuA:
undetectable		 4foxE-2ybuA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 ASP A 205
ARG A 163
ASP A 133
 None
 0.78A 4fp9A-2ybuA:
undetectable		 4fp9A-2ybuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 TYR A 141
GLY A  98
GLY A 102
ASP A 136
ALA A  95
 None
CX9  A1398 (-3.5A)
None
None
None
 1.00A 4krhA-2ybuA:
2.5		 4krhA-2ybuA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 7 THR A  29
TRP A  31
ARG A  35
TRP A 360
LEU A 364
 GOL  A1397 ( 4.8A)
CX9  A1398 ( 3.4A)
GOL  A1397 (-4.2A)
CX9  A1398 ( 3.3A)
None
 0.43A 4nsbA-2ybuA:
55.3		 4nsbA-2ybuA:
49.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		4 / 5 ASP A  73
LEU A  76
ARG A  40
THR A  68
 None
 1.25A 4p3qA-2ybuA:
undetectable		 4p3qA-2ybuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 MET A 358
ASP A 138
PHE A 137
 None
CX9  A1398 (-3.0A)
None
 0.84A 4xeyA-2ybuA:
undetectable		 4xeyA-2ybuA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 MET A 358
ASP A 138
PHE A 137
 None
CX9  A1398 (-3.0A)
None
 0.80A 4xeyB-2ybuA:
undetectable		 4xeyB-2ybuA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 THR A 118
THR A 121
PHE A 126
 None
 0.71A 5cxvA-2ybuA:
undetectable		 5cxvA-2ybuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		3 / 3 TRP A  99
GLU A 140
ASP A 213
 CX9  A1399 ( 3.4A)
CX9  A1398 (-3.7A)
CX9  A1398 ( 4.4A)
 0.27A 5gqbA-2ybuA:
43.9		 5gqbA-2ybuA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		7 / 8 PHE A  58
GLY A  98
TRP A  99
GLU A 140
TYR A 212
ASP A 213
TRP A 360
 CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1399 ( 3.4A)
CX9  A1398 (-3.7A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
CX9  A1398 ( 3.3A)
 0.45A 5gqbA-2ybuA:
43.9		 5gqbA-2ybuA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 ILE A 120
VAL A 180
ALA A 183
ALA A 182
GLY A  98
 None
None
CX9  A1398 ( 4.6A)
None
CX9  A1398 (-3.5A)
 1.39A 5igpA-2ybuA:
undetectable		 5igpA-2ybuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 MET A 162
ILE A 120
ALA A 183
ALA A 182
GLY A  98
 None
None
CX9  A1398 ( 4.6A)
None
CX9  A1398 (-3.5A)
 1.40A 5igpA-2ybuA:
undetectable		 5igpA-2ybuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		4 / 5 VAL A 184
PRO A 142
GLY A 194
TYR A 141
 None
 1.28A 5x80A-2ybuA:
undetectable
5x80B-2ybuA:
undetectable		 5x80A-2ybuA:
16.80
5x80B-2ybuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0F-2ybuA:
undetectable		 6ew0F-2ybuA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0G-2ybuA:
undetectable		 6ew0G-2ybuA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 GLY A 335
GLY A 223
GLU A 224
ASP A 319
GLN A 316
 None
 1.16A 6exiC-2ybuA:
undetectable
6exiD-2ybuA:
undetectable		 6exiC-2ybuA:
11.86
6exiD-2ybuA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens) 		5 / 12 GLN A 316
GLY A 335
GLY A 223
GLU A 224
ASP A 319
 None
 1.16A 6exiC-2ybuA:
undetectable
6exiD-2ybuA:
undetectable		 6exiC-2ybuA:
11.86
6exiD-2ybuA:
11.86