SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ybx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		3 / 3 LEU A 122
SER A 137
ASN A 198
 None
 0.84A 1bx4A-2ybxA:
undetectable		 1bx4A-2ybxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 8 LEU A 159
PHE A  98
PHE A 112
LEU A  41
SER A  70
 None
 1.24A 1wrlC-2ybxA:
undetectable
1wrlD-2ybxA:
undetectable		 1wrlC-2ybxA:
13.28
1wrlD-2ybxA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 10 GLU A 154
MET A 155
ASN A 157
THR A 196
LEU A 101
 None
 1.49A 2ha6A-2ybxA:
undetectable		 2ha6A-2ybxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 12 GLY A 106
TYR A 142
LEU A 116
VAL A  45
ASP A 109
 None
 1.44A 2vqyA-2ybxA:
undetectable		 2vqyA-2ybxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 8 SER A 205
ASP A 282
LEU A 233
PRO A 231
 None
 1.24A 3jq7B-2ybxA:
undetectable		 3jq7B-2ybxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		3 / 3 TYR A 192
TYR A  93
GLU A 150
 None
 0.83A 3pfgA-2ybxA:
2.5		 3pfgA-2ybxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		3 / 3 LEU A 159
HIS A 156
MET A 155
 None
 0.94A 3thrD-2ybxA:
undetectable		 3thrD-2ybxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 12 ASP A 211
ILE A 404
ASP A 235
ARG A 219
PHE A 397
 PHD  A 359 ( 3.1A)
None
None
PO4  A1406 (-3.7A)
None
 1.26A 3wenA-2ybxA:
undetectable		 3wenA-2ybxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 12 ASP A 211
ILE A 404
ASP A 235
ARG A 219
PHE A 397
 PHD  A 359 ( 3.1A)
None
None
PO4  A1406 (-3.7A)
None
 1.23A 3weoA-2ybxA:
undetectable		 3weoA-2ybxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 9 LEU A  52
ASP A 109
VAL A  45
LEU A 116
ILE A  49
 None
 1.44A 3wsjA-2ybxA:
undetectable		 3wsjA-2ybxA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 12 PHE A 112
GLN A 177
ASP A 111
ASP A 108
GLY A 106
 None
 1.49A 4j7xF-2ybxA:
undetectable		 4j7xF-2ybxA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 11 ILE A 358
LEU A 361
LEU A 266
ILE A 357
TYR A 339
 PHD  A 359 ( 3.6A)
None
None
None
None
 1.17A 4p66A-2ybxA:
undetectable		 4p66A-2ybxA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		3 / 3 THR A 173
ASN A 198
PHE A 200
 None
 0.81A 4pd9A-2ybxA:
undetectable		 4pd9A-2ybxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		3 / 3 TYR A  93
ARG A 183
LYS A  91
 None
 1.48A 4wq5B-2ybxA:
undetectable		 4wq5B-2ybxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 5 GLN A 177
PRO A 176
ILE A 357
ASP A 262
 None
 1.28A 4z4hA-2ybxA:
undetectable		 4z4hA-2ybxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 4 ILE A 245
ARG A 349
TYR A 353
GLU A 351
 None
 1.06A 4zzbD-2ybxA:
undetectable		 4zzbD-2ybxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 5 ILE A 245
ARG A 349
TYR A 353
GLU A 351
 None
 1.11A 4zzcE-2ybxA:
undetectable		 4zzcE-2ybxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 7 ILE A 194
ILE A 360
ILE A 158
LEU A 175
 None
PHD  A 359 ( 4.1A)
None
None
 0.59A 5fukA-2ybxA:
undetectable
5fukB-2ybxA:
undetectable		 5fukA-2ybxA:
19.40
5fukB-2ybxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 5 GLN A 113
ASN A 114
THR A 117
LEU A  29
 None
 1.36A 6d8pA-2ybxA:
undetectable		 6d8pA-2ybxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		3 / 3 GLN A  32
TYR A  30
ASN A  83
 None
 0.98A 6dwdC-2ybxA:
undetectable		 6dwdC-2ybxA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 7 ASP A 223
GLU A 220
ASP A 237
GLU A 241
 None
 1.28A 6mn5E-2ybxA:
undetectable		 6mn5E-2ybxA:
11.89