SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ycb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 5 HIS A 247
HIS A 329
HIS A 579
HIS A 603
ASP A 246
 ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.3A)
PO4  A1639 (-3.9A)
ZN  A1637 ( 3.2A)
PO4  A1639 ( 3.8A)
 1.37A 1e9yB-2ycbA:
2.9		 1e9yB-2ycbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLN A 546
TYR A 380
ARG A 582
 None
 0.95A 1gtbA-2ycbA:
undetectable		 1gtbA-2ycbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 LEU A 504
VAL A 442
ILE A 401
GLU A 429
VAL A 531
 None
 1.20A 1gx9A-2ycbA:
undetectable		 1gx9A-2ycbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL A 211
SER A 221
ASN A 220
ASP A 218
 None
 1.23A 1hwiB-2ycbA:
2.5		 1hwiB-2ycbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 211
SER A 221
ASN A 220
ASP A 218
 None
 1.29A 1hwiC-2ycbA:
2.0		 1hwiC-2ycbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 211
SER A 221
ASN A 220
ASP A 218
 None
 1.29A 1hwiD-2ycbA:
2.1		 1hwiD-2ycbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL A 211
SER A 221
ASN A 220
ASP A 218
 None
 1.26A 1hwkC-2ycbA:
undetectable		 1hwkC-2ycbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL A 211
SER A 221
ASN A 220
ASP A 218
 None
 1.25A 1hwkD-2ycbA:
1.7		 1hwkD-2ycbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A 610
ILE A 622
THR A 624
MET A 586
 None
 1.08A 1kglA-2ycbA:
undetectable		 1kglA-2ycbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 352
HIS A 603
HIS A 579
 ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
PO4  A1639 (-3.9A)
 0.68A 1oe1A-2ycbA:
undetectable		 1oe1A-2ycbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 352
HIS A 603
HIS A 579
 ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
PO4  A1639 (-3.9A)
 0.68A 1oe3A-2ycbA:
undetectable		 1oe3A-2ycbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A  95
ALA A  76
ILE A 104
ILE A 123
 None
 0.85A 1oniD-2ycbA:
undetectable
1oniF-2ycbA:
undetectable		 1oniD-2ycbA:
12.40
1oniF-2ycbA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A  95
ILE A  83
ILE A  80
LYS A  79
 None
 0.96A 1sbrB-2ycbA:
undetectable		 1sbrB-2ycbA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 585
THR A 350
ASP A 352
GLY A 604
HIS A 603
 None
None
ZN  A1637 (-2.2A)
None
ZN  A1637 ( 3.2A)
 1.45A 1v8bA-2ycbA:
2.3		 1v8bA-2ycbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 TYR A 349
ASP A 208
SER A 194
HIS A 603
 None
None
None
ZN  A1637 ( 3.2A)
 1.38A 2bteD-2ycbA:
undetectable		 2bteD-2ycbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASN A 212
TYR A 535
SER A 540
 None
 0.74A 2gvcB-2ycbA:
undetectable		 2gvcB-2ycbA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASN A 212
TYR A 535
SER A 540
 None
 0.75A 2gvcE-2ycbA:
undetectable		 2gvcE-2ycbA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A 194
ASP A 208
VAL A 191
LEU A 585
 None
 0.92A 2hdnE-2ycbA:
undetectable
2hdnF-2ycbA:
undetectable
2hdnH-2ycbA:
undetectable		 2hdnE-2ycbA:
6.49
2hdnF-2ycbA:
19.88
2hdnH-2ycbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 191
LEU A 585
SER A 194
ASP A 208
 None
 0.96A 2hdnF-2ycbA:
undetectable
2hdnG-2ycbA:
undetectable
2hdnH-2ycbA:
undetectable		 2hdnF-2ycbA:
19.88
2hdnG-2ycbA:
6.49
2hdnH-2ycbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 THR A 241
SER A 194
ASP A 208
VAL A 191
 None
 1.20A 2hdnI-2ycbA:
undetectable
2hdnJ-2ycbA:
undetectable
2hdnL-2ycbA:
undetectable		 2hdnI-2ycbA:
6.49
2hdnJ-2ycbA:
19.88
2hdnL-2ycbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 VAL A 191
THR A 241
SER A 194
ASP A 208
 None
 1.22A 2hdnJ-2ycbA:
undetectable
2hdnK-2ycbA:
undetectable
2hdnL-2ycbA:
undetectable		 2hdnJ-2ycbA:
19.88
2hdnK-2ycbA:
6.49
2hdnL-2ycbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 149
VAL A 298
THR A 274
 None
 0.88A 2nnkA-2ycbA:
undetectable		 2nnkA-2ycbA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 PHE A 519
LEU A 530
GLN A 546
GLY A 542
LEU A 541
 None
 1.33A 2ok6B-2ycbA:
0.0
2ok6D-2ycbA:
0.0		 2ok6B-2ycbA:
20.71
2ok6D-2ycbA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 PHE A 519
LEU A 530
GLN A 546
GLY A 542
LEU A 541
 None
 1.33A 2ok6A-2ycbA:
0.6
2ok6H-2ycbA:
undetectable		 2ok6A-2ycbA:
20.71
2ok6H-2ycbA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ASP A 246
HIS A 247
HIS A 329
ASP A 352
HIS A 603
 PO4  A1639 ( 3.8A)
ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.3A)
ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
 0.88A 2q0jB-2ycbA:
11.7		 2q0jB-2ycbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 SER A  65
SER A  68
VAL A  69
CYH A 100
GLY A 128
 None
 1.46A 2vinA-2ycbA:
undetectable		 2vinA-2ycbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 HIS A 603
ASP A 246
HIS A 579
ASP A 352
 ZN  A1637 ( 3.2A)
PO4  A1639 ( 3.8A)
PO4  A1639 (-3.9A)
ZN  A1637 (-2.2A)
 1.07A 2xadA-2ycbA:
undetectable		 2xadA-2ycbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 HIS A 603
ASP A 246
HIS A 579
ASP A 352
 ZN  A1637 ( 3.2A)
PO4  A1639 ( 3.8A)
PO4  A1639 (-3.9A)
ZN  A1637 (-2.2A)
 1.05A 2xadB-2ycbA:
undetectable		 2xadB-2ycbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 HIS A 603
ASP A 246
HIS A 579
ASP A 352
 ZN  A1637 ( 3.2A)
PO4  A1639 ( 3.8A)
PO4  A1639 (-3.9A)
ZN  A1637 (-2.2A)
 1.07A 2xadC-2ycbA:
undetectable		 2xadC-2ycbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 HIS A 603
ASP A 246
HIS A 579
ASP A 352
 ZN  A1637 ( 3.2A)
PO4  A1639 ( 3.8A)
PO4  A1639 (-3.9A)
ZN  A1637 (-2.2A)
 1.06A 2xadD-2ycbA:
2.3		 2xadD-2ycbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 352
HIS A 603
HIS A 579
 ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
PO4  A1639 (-3.9A)
 0.70A 2xxgA-2ycbA:
undetectable		 2xxgA-2ycbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 352
HIS A 603
HIS A 579
 ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
PO4  A1639 (-3.9A)
 0.70A 2xxgC-2ycbA:
undetectable		 2xxgC-2ycbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A 495
ASP A 445
SER A 501
PRO A 441
ILE A 413
 None
 1.22A 3clbB-2ycbA:
undetectable		 3clbB-2ycbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 534
GLY A 542
GLY A 508
VAL A 566
ILE A 570
 None
 0.94A 3elwA-2ycbA:
undetectable		 3elwA-2ycbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 279
LEU A 275
GLN A 422
 None
 0.79A 3g4lA-2ycbA:
undetectable		 3g4lA-2ycbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 149
VAL A 298
THR A 274
 None
 0.80A 3k4vA-2ycbA:
undetectable		 3k4vA-2ycbA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PHE A 416
TYR A 535
LEU A 331
 None
 0.56A 3keeB-2ycbA:
undetectable		 3keeB-2ycbA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ILE A  93
PHE A  95
ASP A  96
GLU A 101
 None
 0.97A 3kp6A-2ycbA:
undetectable
3kp6B-2ycbA:
undetectable		 3kp6A-2ycbA:
13.97
3kp6B-2ycbA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 207
LEU A 198
VAL A 205
SER A 203
LEU A 308
 None
 1.04A 3m7rA-2ycbA:
undetectable		 3m7rA-2ycbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 149
VAL A 298
THR A 274
 None
 0.78A 3ndtA-2ycbA:
undetectable		 3ndtA-2ycbA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 149
VAL A 298
THR A 274
 None
 0.82A 3pwrA-2ycbA:
undetectable		 3pwrA-2ycbA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PHE A 416
TYR A 535
LEU A 331
 None
 0.71A 3sueB-2ycbA:
undetectable		 3sueB-2ycbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 149
VAL A 298
THR A 274
 None
 0.88A 3tl9A-2ycbA:
undetectable		 3tl9A-2ycbA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A 437
ILE A 411
LEU A 424
VAL A 427
 None
 0.79A 3ua5B-2ycbA:
undetectable		 3ua5B-2ycbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 579
GLY A 419
GLY A 534
ALA A 451
LEU A 272
 PO4  A1639 (-3.9A)
None
None
None
None
 1.17A 3vywC-2ycbA:
undetectable		 3vywC-2ycbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 GLU A 423
GLU A 394
GLY A 534
ARG A 420
 None
 1.04A 4fgzA-2ycbA:
undetectable
4fgzB-2ycbA:
undetectable		 4fgzA-2ycbA:
18.44
4fgzB-2ycbA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 TYR A 222
PRO A 223
GLY A 249
ILE A 240
LEU A 206
 None
 1.32A 4kovA-2ycbA:
undetectable		 4kovA-2ycbA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ARG A 168
GLY A 166
ASP A 236
PRO A 318
 None
 0.97A 4lajA-2ycbA:
undetectable
4lajB-2ycbA:
undetectable		 4lajA-2ycbA:
20.50
4lajB-2ycbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 PRO A 252
SER A 301
VAL A 298
GLY A 210
 None
 0.88A 4mk4A-2ycbA:
3.8		 4mk4A-2ycbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 PRO A 252
VAL A 298
VAL A 211
GLY A 210
 None
 0.96A 4mk4A-2ycbA:
3.8		 4mk4A-2ycbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A 444
LYS A 485
ILE A 448
ALA A 451
 None
 0.94A 4ou1A-2ycbA:
2.2		 4ou1A-2ycbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A 506
ASN A 514
SER A 515
 None
 0.74A 4tvtA-2ycbA:
undetectable		 4tvtA-2ycbA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 424
VAL A 427
ILE A 432
VAL A 442
PHE A 483
 None
 1.13A 4y0qA-2ycbA:
1.6		 4y0qA-2ycbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 504
VAL A 442
ILE A 401
GLU A 429
VAL A 531
 None
 1.13A 4y0qA-2ycbA:
1.6		 4y0qA-2ycbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 LEU A 428
GLU A 491
ILE A 448
VAL A 415
VAL A 533
LEU A 397
 None
 1.34A 4y0sA-2ycbA:
undetectable		 4y0sA-2ycbA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL A 191
HIS A 244
HIS A 329
HIS A 603
 None
ZN  A1638 ( 3.1A)
ZN  A1638 ( 3.3A)
ZN  A1637 ( 3.2A)
 0.83A 5a5zA-2ycbA:
8.4		 5a5zA-2ycbA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 HIS A 242
HIS A 244
ASP A 246
HIS A 329
HIS A 603
 ZN  A1638 ( 3.2A)
ZN  A1638 ( 3.1A)
PO4  A1639 ( 3.8A)
ZN  A1638 ( 3.3A)
ZN  A1637 ( 3.2A)
 0.81A 5ayaA-2ycbA:
11.5		 5ayaA-2ycbA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 HIS A 242
HIS A 244
HIS A 247
HIS A 329
HIS A 603
 ZN  A1638 ( 3.2A)
ZN  A1638 ( 3.1A)
ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.3A)
ZN  A1637 ( 3.2A)
 0.46A 5ayaA-2ycbA:
11.5		 5ayaA-2ycbA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A 141
ALA A 453
LEU A 275
LEU A 272
 None
 1.18A 5dzkF-2ycbA:
undetectable
5dzkT-2ycbA:
undetectable		 5dzkF-2ycbA:
15.43
5dzkT-2ycbA:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 VAL A 533
VAL A 531
ILE A 437
ILE A 502
LEU A 424
 None
 0.86A 5e4dB-2ycbA:
undetectable		 5e4dB-2ycbA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLY A 604
THR A 379
VAL A 191
HIS A 247
 None
None
None
ZN  A1637 ( 3.2A)
 1.15A 5ewuA-2ycbA:
undetectable		 5ewuA-2ycbA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLY A 604
THR A 379
VAL A 191
HIS A 247
 None
None
None
ZN  A1637 ( 3.2A)
 1.06A 5ewuB-2ycbA:
undetectable		 5ewuB-2ycbA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A 471
LEU A 466
PRO A 138
PHE A 478
LEU A 134
 None
 1.31A 5ljbA-2ycbA:
undetectable		 5ljbA-2ycbA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 610
ILE A 622
THR A 624
MET A 586
 None
 1.25A 5ljeA-2ycbA:
undetectable		 5ljeA-2ycbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLU A 394
THR A 434
TYR A 431
PHE A 576
 None
 1.33A 5lrbA-2ycbA:
undetectable		 5lrbA-2ycbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 HIS A 579
HIS A 603
HIS A 242
HIS A 244
LEU A 245
 PO4  A1639 (-3.9A)
ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.2A)
ZN  A1638 ( 3.1A)
None
 1.35A 5m8nA-2ycbA:
undetectable		 5m8nA-2ycbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 HIS A 579
HIS A 603
HIS A 242
HIS A 244
LEU A 245
 PO4  A1639 (-3.9A)
ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.2A)
ZN  A1638 ( 3.1A)
None
 1.41A 5m8nB-2ycbA:
undetectable		 5m8nB-2ycbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 ASP A 246
HIS A 603
HIS A 579
HIS A 244
 PO4  A1639 ( 3.8A)
ZN  A1637 ( 3.2A)
PO4  A1639 (-3.9A)
ZN  A1638 ( 3.1A)
 1.39A 5ncdD-2ycbA:
undetectable		 5ncdD-2ycbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		7 / 10 HIS A 242
HIS A 244
HIS A 247
HIS A 329
ASP A 352
TYR A 380
HIS A 579
 ZN  A1638 ( 3.2A)
ZN  A1638 ( 3.1A)
ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.3A)
ZN  A1637 (-2.2A)
None
PO4  A1639 (-3.9A)
 0.38A 5nzwA-2ycbA:
22.4		 5nzwA-2ycbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 HIS A 329
HIS A 242
HIS A 579
ASP A 352
HIS A 603
 ZN  A1638 ( 3.3A)
ZN  A1638 ( 3.2A)
PO4  A1639 (-3.9A)
ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
 1.00A 5nzwA-2ycbA:
22.4		 5nzwA-2ycbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 THR A  91
THR A 136
ALA A 106
ARG A 107
 None
 1.47A 5wm7A-2ycbA:
2.1		 5wm7A-2ycbA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 ( 3.3A)
 0.72A 5xioA-2ycbA:
undetectable		 5xioA-2ycbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 ( 3.3A)
 0.74A 5xiqB-2ycbA:
undetectable		 5xiqB-2ycbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 ( 3.3A)
 0.75A 5xiqD-2ycbA:
undetectable		 5xiqD-2ycbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 192
GLY A 186
ASN A 212
TYR A 535
TYR A 349
 None
 1.39A 5yf0A-2ycbA:
undetectable		 5yf0A-2ycbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ALA A 327
SER A 333
GLY A 332
TYR A 310
 None
 1.12A 5yodB-2ycbA:
undetectable		 5yodB-2ycbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ALA A 327
SER A 333
GLY A 332
TYR A 310
 None
 1.19A 5yodD-2ycbA:
undetectable		 5yodD-2ycbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 308
LEU A 322
SER A 203
GLY A 166
LEU A 165
 None
 0.84A 6b0iB-2ycbA:
undetectable		 6b0iB-2ycbA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 308
LEU A 322
SER A 203
GLY A 166
LEU A 165
 None
 0.96A 6b0lB-2ycbA:
undetectable		 6b0lB-2ycbA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 435
ASP A 438
ILE A 401
 None
 0.53A 6dgxB-2ycbA:
undetectable		 6dgxB-2ycbA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LEU A 196
ASP A 236
ILE A 316
 None
 0.52A 6dh0B-2ycbA:
undetectable		 6dh0B-2ycbA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ALA A 237
VAL A 633
LEU A 322
ALA A 336
TYR A 264
 None
 1.16A 6djzC-2ycbA:
undetectable		 6djzC-2ycbA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A 196
LEU A 338
THR A 350
PRO A 594
 None
 0.91A 6ew0F-2ycbA:
undetectable		 6ew0F-2ycbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 196
LEU A 338
THR A 350
PRO A 594
 None
 0.91A 6ew0G-2ycbA:
undetectable		 6ew0G-2ycbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ASN A  39
PRO A  40
ILE A  42
GLU A  45
 None
 1.23A 6h7uA-2ycbA:
undetectable		 6h7uA-2ycbA:
21.41