SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ych'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 10 LEU A 208
ALA A 365
VAL A 195
TYR A 179
LEU A 181
 None
 1.40A 1aqbA-2ychA:
0.0		 1aqbA-2ychA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 6 LEU A 214
LEU A 194
LEU A 185
LEU A 219
 None
 0.80A 1errA-2ychA:
undetectable		 1errA-2ychA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 11 LEU A 208
ALA A 365
VAL A 195
TYR A 179
LEU A 181
 None
 1.36A 1hbpA-2ychA:
undetectable		 1hbpA-2ychA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 4 LEU A 194
PRO A 307
LEU A 207
ARG A 217
 None
 1.33A 1hrkB-2ychA:
undetectable		 1hrkB-2ychA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 11 LEU A 208
ALA A 365
VAL A 195
TYR A 179
LEU A 181
 None
 1.43A 1kt7A-2ychA:
undetectable		 1kt7A-2ychA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 ALA A 363
GLY A 367
LEU A 178
LEU A 370
PRO A 339
 None
 1.15A 2f8lA-2ychA:
2.0		 2f8lA-2ychA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 4 LEU A 194
PRO A 307
LEU A 207
ARG A 217
 None
 1.32A 2hrcB-2ychA:
undetectable		 2hrcB-2ychA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 LEU A 313
LEU A 322
ALA A 323
LEU A 291
LEU A 194
 None
 1.12A 2oaxB-2ychA:
undetectable		 2oaxB-2ychA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 LEU A 313
LEU A 322
ALA A 323
LEU A 291
LEU A 194
 None
 1.11A 2oaxD-2ychA:
undetectable		 2oaxD-2ychA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 LEU A 313
LEU A 322
ALA A 323
LEU A 291
LEU A 194
 None
 1.12A 2oaxE-2ychA:
undetectable		 2oaxE-2ychA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 4 LEU A 194
PRO A 307
LEU A 207
ARG A 217
 None
 1.38A 2pnjB-2ychA:
undetectable		 2pnjB-2ychA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 8 PHE A 193
GLY A 310
VAL A 332
PRO A 307
 None
 0.81A 3bgdB-2ychA:
undetectable		 3bgdB-2ychA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 5 LEU A 221
GLN A 289
LEU A 287
GLU A 286
 None
 0.93A 3h5gA-2ychA:
undetectable
3h5gB-2ychA:
undetectable		 3h5gA-2ychA:
7.07
3h5gB-2ychA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 VAL A 195
SER A 204
SER A 202
LEU A  90
VAL A  88
 None
None
ATP  A 502 (-4.7A)
None
None
 1.06A 3w68A-2ychA:
undetectable		 3w68A-2ychA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 8 GLY A 367
GLY A 372
GLU A 374
VAL A 169
 None
 0.90A 4fgzA-2ychA:
undetectable		 4fgzA-2ychA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 8 GLY A 367
GLY A 372
GLU A 374
VAL A 169
 None
 0.91A 4fgzB-2ychA:
undetectable		 4fgzB-2ychA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 ILE A  20
LEU A 368
GLY A  17
VAL A 364
ALA A 363
 None
 1.18A 4foxD-2ychA:
undetectable		 4foxD-2ychA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 6 ASN A 333
ASP A 328
GLY A 321
PRO A 336
 None
 0.95A 4l1aB-2ychA:
undetectable		 4l1aB-2ychA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 10 LEU A 312
THR A 288
LEU A 291
LEU A 330
LEU A 334
 None
 0.99A 4z91A-2ychA:
undetectable
4z91B-2ychA:
undetectable
4z91C-2ychA:
undetectable
4z91D-2ychA:
undetectable
4z91E-2ychA:
undetectable		 4z91A-2ychA:
21.77
4z91B-2ychA:
21.77
4z91C-2ychA:
21.77
4z91D-2ychA:
21.77
4z91E-2ychA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 10 LEU A 330
LEU A 334
LEU A 312
THR A 288
LEU A 291
 None
 1.04A 4z91A-2ychA:
undetectable
4z91B-2ychA:
undetectable
4z91C-2ychA:
undetectable
4z91D-2ychA:
undetectable
4z91E-2ychA:
undetectable		 4z91A-2ychA:
21.77
4z91B-2ychA:
21.77
4z91C-2ychA:
21.77
4z91D-2ychA:
21.77
4z91E-2ychA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 10 THR A 288
LEU A 291
LEU A 330
LEU A 334
LEU A 312
 None
 1.03A 4z91A-2ychA:
undetectable
4z91B-2ychA:
undetectable
4z91C-2ychA:
undetectable
4z91D-2ychA:
undetectable
4z91E-2ychA:
undetectable		 4z91A-2ychA:
21.77
4z91B-2ychA:
21.77
4z91C-2ychA:
21.77
4z91D-2ychA:
21.77
4z91E-2ychA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 6 SER A 204
ASP A 171
ARG A 371
GLY A 367
 None
 0.92A 5cdqA-2ychA:
undetectable
5cdqC-2ychA:
undetectable
5cdqD-2ychA:
undetectable		 5cdqA-2ychA:
24.90
5cdqC-2ychA:
24.90
5cdqD-2ychA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		4 / 5 LEU A  27
ALA A 369
LEU A  18
VAL A 373
 None
 1.20A 5cr1A-2ychA:
undetectable		 5cr1A-2ychA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2ych COMPETENCE PROTEIN
PILM
(Thermus
thermophilus) 		5 / 12 ILE A  65
ILE A  20
ALA A  82
ALA A 369
GLU A  29
 None
 1.13A 5vceA-2ychA:
undetectable		 5vceA-2ychA:
21.74