SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ycm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 SER A 112
ILE A 177
VAL A 122
SER A 172
 None
30A  A1306 (-3.7A)
None
None
 1.12A 1kb9A-2ycmA:
undetectable
1kb9C-2ycmA:
undetectable
1kb9D-2ycmA:
undetectable
1kb9E-2ycmA:
undetectable		 1kb9A-2ycmA:
20.09
1kb9C-2ycmA:
20.10
1kb9D-2ycmA:
20.85
1kb9E-2ycmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ILE A 125
PHE A 114
PHE A 113
ILE A 136
VAL A 127
 None
 1.27A 2w3aA-2ycmA:
undetectable		 2w3aA-2ycmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 SER A 112
HIS A 178
LEU A 184
LEU A 291
LEU A  83
 None
 1.36A 3adsA-2ycmA:
undetectable		 3adsA-2ycmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 SER A 112
HIS A 178
LEU A 184
LEU A 291
LEU A  83
 None
 1.37A 3adxA-2ycmA:
undetectable		 3adxA-2ycmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 PHE A 116
CYH A 176
HIS A 178
 None
 1.17A 3u9fF-2ycmA:
undetectable		 3u9fF-2ycmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 PHE A 116
CYH A 176
HIS A 178
 None
 1.20A 3u9fG-2ycmA:
undetectable		 3u9fG-2ycmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 8 ARG A 182
VAL A 204
VAL A 275
ASP A 262
GLN A 238
 None
30A  A1306 ( 4.2A)
None
30A  A1306 (-4.0A)
30A  A1306 (-3.4A)
 1.49A 3uy4A-2ycmA:
2.2		 3uy4A-2ycmA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 CYH A 176
GLN A 238
PRO A 237
ASP A 179
 None
30A  A1306 (-3.4A)
None
None
 1.04A 4w5oA-2ycmA:
undetectable		 4w5oA-2ycmA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 THR A 187
THR A 115
ARG A 118
 None
 1.04A 5wm2A-2ycmA:
undetectable		 5wm2A-2ycmA:
18.15