SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 GLN A 358
TYR A 327
ARG A 328
 None
 0.90A 1gtbA-2yd0A:
undetectable		 1gtbA-2yd0A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		6 / 12 THR A 350
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.77A 1j36A-2yd0A:
5.9		 1j36A-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		6 / 12 THR A 350
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.77A 1j36B-2yd0A:
6.7		 1j36B-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.77A 1j37A-2yd0A:
6.4		 1j37A-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.78A 1j37B-2yd0A:
6.6		 1j37B-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.75A 1o86A-2yd0A:
6.7		 1o86A-2yd0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 324
ALA A 309
SER A 268
SER A 258
 None
 0.84A 1tz8C-2yd0A:
undetectable
1tz8D-2yd0A:
undetectable		 1tz8C-2yd0A:
10.09
1tz8D-2yd0A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 SER A 648
PHE A 702
PHE A 699
MET A 683
 None
 0.98A 1wrlC-2yd0A:
undetectable
1wrlD-2yd0A:
undetectable		 1wrlC-2yd0A:
6.69
1wrlD-2yd0A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 TYR A 245
SER A 243
THR A 365
ASN A 375
 None
 1.36A 1yvpA-2yd0A:
undetectable		 1yvpA-2yd0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 ILE A 429
MET A 366
ASP A 371
GLY A 377
TYR A 245
 None
 1.20A 2azyA-2yd0A:
undetectable		 2azyA-2yd0A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		6 / 12 ALA A 318
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 BES  A1950 (-4.9A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.72A 2c6nA-2yd0A:
6.6		 2c6nA-2yd0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.80A 2c6nB-2yd0A:
3.9		 2c6nB-2yd0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.78A 2eilP-2yd0A:
undetectable
2eilW-2yd0A:
undetectable		 2eilP-2yd0A:
14.57
2eilW-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 THR A 350
HIS A 353
GLU A 354
HIS A 357
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
 0.23A 2jihB-2yd0A:
3.8		 2jihB-2yd0A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 ILE A 207
LEU A 155
ILE A  67
PHE A 249
 None
 0.69A 2w9sE-2yd0A:
undetectable		 2w9sE-2yd0A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 LEU A 591
ILE A 535
TYR A 612
PHE A 569
 None
 0.96A 2weyB-2yd0A:
undetectable		 2weyB-2yd0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.70A 2x8zA-2yd0A:
7.0		 2x8zA-2yd0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.72A 2x91A-2yd0A:
5.4		 2x91A-2yd0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ASP A 274
THR A 326
GLU A 329
 None
 0.68A 2zifB-2yd0A:
undetectable		 2zifB-2yd0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 SER A 723
GLU A 667
ASP A 398
 None
 0.84A 2zthA-2yd0A:
undetectable		 2zthA-2yd0A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.75A 3abkP-2yd0A:
undetectable
3abkW-2yd0A:
undetectable		 3abkP-2yd0A:
14.57
3abkW-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.74A 3asoC-2yd0A:
undetectable
3asoJ-2yd0A:
undetectable		 3asoC-2yd0A:
14.57
3asoJ-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 VAL A 147
VAL A 148
PRO A 192
ARG A 108
 None
 0.98A 3bjwA-2yd0A:
2.0		 3bjwA-2yd0A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 SER A 723
GLU A 667
ASP A 398
 None
 0.79A 3bwmA-2yd0A:
undetectable		 3bwmA-2yd0A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 SER A 723
GLU A 667
ASP A 398
 None
 0.83A 3bwyA-2yd0A:
undetectable		 3bwyA-2yd0A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLN A 851
LEU A 860
VAL A 875
LEU A 898
 None
 0.95A 3g8iA-2yd0A:
undetectable		 3g8iA-2yd0A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 MET A 382
GLY A 377
LEU A 478
MET A 482
LEU A 448
 None
 1.35A 3h52D-2yd0A:
undetectable		 3h52D-2yd0A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 SER A 481
TYR A 464
PHE A 378
LEU A 374
 None
 0.71A 3i45A-2yd0A:
undetectable		 3i45A-2yd0A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 353
GLU A 354
HIS A 357
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
 0.17A 3kecB-2yd0A:
4.8		 3kecB-2yd0A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 9 GLY A 153
ILE A 207
PHE A 203
GLY A 161
PHE A 182
 NAG  A1942 ( 4.4A)
None
None
None
None
 1.38A 3ko0A-2yd0A:
undetectable
3ko0C-2yd0A:
undetectable		 3ko0A-2yd0A:
9.55
3ko0C-2yd0A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLU A 354
TYR A 245
PHE A 314
TYR A 327
 BES  A1950 (-3.3A)
None
None
None
 1.31A 3ku9B-2yd0A:
undetectable		 3ku9B-2yd0A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 PHE A 297
ASN A 375
PHE A 360
ALA A 379
 None
None
None
ZN  A1946 ( 4.2A)
 0.86A 3t3sF-2yd0A:
undetectable		 3t3sF-2yd0A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.76A 3wg7P-2yd0A:
undetectable
3wg7W-2yd0A:
undetectable		 3wg7P-2yd0A:
14.57
3wg7W-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.78A 4c2pA-2yd0A:
undetectable		 4c2pA-2yd0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 9 GLY A 317
HIS A 353
GLU A 354
GLU A 376
TYR A 438
 BES  A1950 (-3.7A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.36A 4dprA-2yd0A:
32.3		 4dprA-2yd0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 ILE A 929
LEU A 658
PHE A 644
GLY A 676
 None
 0.80A 4hajA-2yd0A:
undetectable		 4hajA-2yd0A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ASP A 195
ARG A 430
THR A 244
 None
 0.74A 4i13A-2yd0A:
undetectable		 4i13A-2yd0A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 PHE A 194
HIS A  96
PHE A 199
PRO A 426
 None
 1.21A 4o8zA-2yd0A:
undetectable		 4o8zA-2yd0A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 ASP A 195
ARG A 430
THR A 244
 None
 0.72A 4p3rA-2yd0A:
undetectable		 4p3rA-2yd0A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 445
HIS A 357
HIS A 353
GLU A 376
 None
BES  A1950 ( 3.3A)
ZN  A1946 ( 3.3A)
ZN  A1946 ( 2.1A)
 0.99A 4pahA-2yd0A:
undetectable		 4pahA-2yd0A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		7 / 12 HIS A 353
GLU A 354
HIS A 357
TRP A 369
PHE A 433
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
None
BES  A1950 ( 4.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 1.31A 4r7lA-2yd0A:
43.9		 4r7lA-2yd0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 MET A 408
GLN A 527
TYR A 561
 None
 0.98A 4udcA-2yd0A:
undetectable		 4udcA-2yd0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 GLY A 529
GLN A 527
SER A 416
HIS A 548
 None
 0.89A 4wryA-2yd0A:
undetectable		 4wryA-2yd0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 GLY A 529
GLN A 527
SER A 416
HIS A 548
 None
 0.87A 4wrzA-2yd0A:
undetectable		 4wrzA-2yd0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 VAL A 423
GLU A 431
GLY A 867
ILE A 871
SER A 870
 None
K  A1947 (-4.5A)
None
None
None
 1.46A 4xudA-2yd0A:
undetectable		 4xudA-2yd0A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 SER A 723
GLU A 667
ASP A 398
 None
 0.74A 4xudA-2yd0A:
undetectable		 4xudA-2yd0A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.72A 5b1aC-2yd0A:
undetectable
5b1aJ-2yd0A:
undetectable		 5b1aC-2yd0A:
14.57
5b1aJ-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.73A 5b1aP-2yd0A:
undetectable
5b1aW-2yd0A:
undetectable		 5b1aP-2yd0A:
14.57
5b1aW-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.71A 5b3sC-2yd0A:
undetectable
5b3sJ-2yd0A:
undetectable		 5b3sC-2yd0A:
14.57
5b3sJ-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.70A 5b3sP-2yd0A:
undetectable		 5b3sP-2yd0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 SER A 821
GLU A 820
GLY A 877
GLY A 840
 None
 0.63A 5cdnA-2yd0A:
2.1
5cdnB-2yd0A:
undetectable		 5cdnA-2yd0A:
19.04
5cdnB-2yd0A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 SER A 821
GLU A 820
GLY A 877
GLY A 840
 None
 0.67A 5cdnR-2yd0A:
2.0
5cdnS-2yd0A:
undetectable		 5cdnR-2yd0A:
19.04
5cdnS-2yd0A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 676
GLN A 675
LEU A 686
GLY A 920
PHE A 699
 None
 0.90A 5fsaB-2yd0A:
undetectable		 5fsaB-2yd0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 9 MET A 692
VAL A 695
LEU A 933
ILE A 929
LEU A 734
 None
 1.49A 5iepA-2yd0A:
undetectable		 5iepA-2yd0A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.76A 5iy5C-2yd0A:
undetectable
5iy5J-2yd0A:
undetectable		 5iy5C-2yd0A:
14.84
5iy5J-2yd0A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 ASP A 274
THR A 169
ARG A 175
GLU A 171
 None
 1.39A 5k9dA-2yd0A:
undetectable		 5k9dA-2yd0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 TYR A 296
PHE A 297
ALA A 379
GLY A 377
 None
None
ZN  A1946 ( 4.2A)
None
 1.07A 5uxdA-2yd0A:
1.8		 5uxdA-2yd0A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 377
ALA A 442
PHE A 360
TYR A 293
GLU A 354
 None
None
None
None
BES  A1950 (-3.3A)
 1.42A 5wbvA-2yd0A:
undetectable		 5wbvA-2yd0A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 377
ALA A 442
PHE A 360
TYR A 293
GLU A 354
 None
None
None
None
BES  A1950 (-3.3A)
 1.42A 5wbvB-2yd0A:
undetectable		 5wbvB-2yd0A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 PRO A 302
LYS A 305
THR A 239
TYR A 470
 None
 1.15A 5x2sI-2yd0A:
undetectable
5x2sJ-2yd0A:
undetectable
5x2sK-2yd0A:
undetectable		 5x2sI-2yd0A:
10.30
5x2sJ-2yd0A:
10.69
5x2sK-2yd0A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 GLN A 830
TYR A 163
GLU A 329
ASP A 274
 None
 1.46A 5yf0A-2yd0A:
0.0		 5yf0A-2yd0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.75A 5z84C-2yd0A:
undetectable
5z84J-2yd0A:
undetectable		 5z84C-2yd0A:
14.57
5z84J-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 GLY A 323
ASP A 307
ILE A 250
 None
 0.57A 6dgxB-2yd0A:
undetectable		 6dgxB-2yd0A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_1
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 ASN A 218
GLN A 181
TYR A 438
MET A 242
 None
BES  A1950 (-4.1A)
BES  A1950 (-4.3A)
None
 0.88A 6hlpA-2yd0A:
0.0		 6hlpA-2yd0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 SER A 638
LEU A 582
VAL A 565
ASP A 587
LYS A 599
 None
 1.27A 6i5zD-2yd0A:
undetectable		 6i5zD-2yd0A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 GLN A 358
GLU A 354
ASN A 375
TYR A 293
 None
BES  A1950 (-3.3A)
None
None
 1.36A 6iftA-2yd0A:
undetectable		 6iftA-2yd0A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 445
HIS A 357
HIS A 353
GLU A 376
 None
BES  A1950 ( 3.3A)
ZN  A1946 ( 3.3A)
ZN  A1946 ( 2.1A)
 1.01A 6pahA-2yd0A:
undetectable		 6pahA-2yd0A:
15.70