SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 1d1wA-2yd3A:
undetectable
1d1wB-2yd3A:
undetectable		 1d1wA-2yd3A:
19.41
1d1wB-2yd3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.50A 1dm8A-2yd3A:
undetectable
1dm8B-2yd3A:
undetectable		 1dm8A-2yd3A:
19.41
1dm8B-2yd3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 1fopA-2yd3A:
undetectable
1fopB-2yd3A:
undetectable		 1fopA-2yd3A:
19.41
1fopB-2yd3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.47A 1p6mA-2yd3A:
undetectable
1p6mB-2yd3A:
undetectable		 1p6mA-2yd3A:
19.76
1p6mB-2yd3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.47A 1p6nA-2yd3A:
undetectable
1p6nB-2yd3A:
undetectable		 1p6nA-2yd3A:
19.76
1p6nB-2yd3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 LEU A  96
LEU A 122
ALA A 213
PHE A 134
LEU A 130
 None
 1.00A 2h42C-2yd3A:
undetectable		 2h42C-2yd3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ARG A  92
LEU A 122
PHE A  52
ALA A  50
VAL A  49
 None
 1.00A 2oc8A-2yd3A:
undetectable		 2oc8A-2yd3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 TRP A 168
VAL A 146
ARG A 228
 None
 0.92A 3b0wA-2yd3A:
undetectable		 3b0wA-2yd3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 3dqtA-2yd3A:
0.0
3dqtB-2yd3A:
0.0		 3dqtA-2yd3A:
19.76
3dqtB-2yd3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.49A 3nliA-2yd3A:
0.0
3nliB-2yd3A:
0.0		 3nliA-2yd3A:
19.41
3nliB-2yd3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.50A 3nluA-2yd3A:
0.0
3nluB-2yd3A:
0.0		 3nluA-2yd3A:
19.41
3nluB-2yd3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
 None
None
None
NA  A1229 (-4.5A)
None
 1.19A 4ffwA-2yd3A:
undetectable		 4ffwA-2yd3A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
 None
None
None
NA  A1229 (-4.5A)
None
 1.19A 4ffwB-2yd3A:
undetectable		 4ffwB-2yd3A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 4uh8A-2yd3A:
undetectable
4uh8B-2yd3A:
undetectable		 4uh8A-2yd3A:
19.46
4uh8B-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.50A 5adlA-2yd3A:
undetectable
5adlB-2yd3A:
undetectable		 5adlA-2yd3A:
19.46
5adlB-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 5fj2A-2yd3A:
undetectable
5fj2B-2yd3A:
undetectable		 5fj2A-2yd3A:
19.46
5fj2B-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 5fvzA-2yd3A:
undetectable
5fvzB-2yd3A:
undetectable		 5fvzA-2yd3A:
19.46
5fvzB-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A 183
THR A 200
ASP A 201
 None
 0.51A 5g5gA-2yd3A:
undetectable
5g5gB-2yd3A:
undetectable		 5g5gA-2yd3A:
24.22
5g5gB-2yd3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.47A 5uo8C-2yd3A:
0.0
5uo8D-2yd3A:
0.0		 5uo8C-2yd3A:
19.36
5uo8D-2yd3A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 7 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.49A 5uo9C-2yd3A:
undetectable
5uo9D-2yd3A:
undetectable		 5uo9C-2yd3A:
19.36
5uo9D-2yd3A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 5vv7A-2yd3A:
undetectable
5vv7B-2yd3A:
undetectable		 5vv7A-2yd3A:
19.46
5vv7B-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 7 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.47A 5vv9A-2yd3A:
undetectable
5vv9B-2yd3A:
undetectable		 5vv9A-2yd3A:
19.46
5vv9B-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.49A 5vvgA-2yd3A:
0.0
5vvgB-2yd3A:
0.0		 5vvgA-2yd3A:
19.46
5vvgB-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.47A 5vvnA-2yd3A:
0.0
5vvnB-2yd3A:
0.0		 5vvnA-2yd3A:
19.46
5vvnB-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.49A 6av7C-2yd3A:
0.0
6av7D-2yd3A:
0.0		 6av7C-2yd3A:
17.68
6av7D-2yd3A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 7 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.47A 6cieA-2yd3A:
undetectable
6cieB-2yd3A:
undetectable		 6cieA-2yd3A:
17.68
6cieB-2yd3A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.47A 6cifA-2yd3A:
0.0
6cifB-2yd3A:
0.0		 6cifA-2yd3A:
17.68
6cifB-2yd3A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.47A 8nseA-2yd3A:
undetectable
8nseB-2yd3A:
undetectable		 8nseA-2yd3A:
19.41
8nseB-2yd3A:
19.41