SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ALA A 454
TYR A 456
SER A 387
ALA A 403
 None
 1.04A 1k5qA-2yeqA:
undetectable
1k5qB-2yeqA:
undetectable		 1k5qA-2yeqA:
17.49
1k5qB-2yeqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 GLY A 166
SER A 163
TYR A 131
HIS A 129
 PE5  A 558 ( 3.7A)
None
None
None
 1.06A 1maaD-2yeqA:
undetectable		 1maaD-2yeqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 TYR A 135
GLY A 441
ALA A 120
SER A 123
HIS A 148
 None
 1.16A 1nbiC-2yeqA:
undetectable		 1nbiC-2yeqA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 ARG A 420
ILE A 433
TRP A 337
PHE A 436
 None
 1.26A 1nsiA-2yeqA:
undetectable
1nsiB-2yeqA:
undetectable		 1nsiA-2yeqA:
24.14
1nsiB-2yeqA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 PHE A 436
ARG A 420
ILE A 433
TRP A 337
 None
 1.20A 1nsiA-2yeqA:
undetectable
1nsiB-2yeqA:
undetectable		 1nsiA-2yeqA:
24.14
1nsiB-2yeqA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 GLY A 416
GLY A 414
ASP A 500
SER A 499
PHE A 461
 None
None
None
None
EDO  A 533 ( 4.2A)
 1.06A 1ri4A-2yeqA:
undetectable		 1ri4A-2yeqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 ASP A  80
LEU A  25
TRP A  48
THR A 106
 None
 1.10A 1rmtD-2yeqA:
undetectable		 1rmtD-2yeqA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ARG A 359
ASN A 430
HIS A 432
TYR A 347
 PE5  A 531 (-3.8A)
None
EDO  A 579 (-4.0A)
PE5  A 531 (-3.6A)
 1.43A 1tdnA-2yeqA:
undetectable		 1tdnA-2yeqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 ASP A 380
GLU A 155
TYR A 239
 CA  A1525 ( 3.4A)
None
None
 0.81A 1wsvA-2yeqA:
undetectable		 1wsvA-2yeqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 ASP A 438
PHE A 436
ARG A 420
 None
 0.81A 2a3aA-2yeqA:
2.3		 2a3aA-2yeqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 GLY A  16
LEU A  25
GLY A 102
ALA A 200
ALA A 197
 None
None
PE5  A 530 ( 4.7A)
PE5  A 530 ( 3.9A)
PE5  A 530 (-4.1A)
 0.98A 2bm9F-2yeqA:
undetectable		 2bm9F-2yeqA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 ASP A 350
SER A 351
ASN A 291
TRP A 337
 None
None
EDO  A 540 ( 4.3A)
None
 1.12A 2cmlB-2yeqA:
undetectable		 2cmlB-2yeqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 ASP A 350
SER A 351
ASN A 291
TRP A 337
 None
None
EDO  A 540 ( 4.3A)
None
 1.13A 2cmlD-2yeqA:
undetectable		 2cmlD-2yeqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 VAL A 502
GLU A 504
GLU A 503
 EDO  A 540 ( 4.6A)
EDO  A 540 (-3.7A)
None
 0.77A 2nv4A-2yeqA:
undetectable		 2nv4A-2yeqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 THR A 207
ASP A 210
ASN A 216
ASP A 289
 None
CA  A1526 (-2.8A)
CA  A1526 (-3.3A)
None
 1.33A 2okcA-2yeqA:
undetectable		 2okcA-2yeqA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 SER A 499
HIS A 129
ASP A 151
 None
None
CA  A1525 (-2.4A)
 0.65A 2oxtA-2yeqA:
undetectable		 2oxtA-2yeqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 11 LEU A 305
LEU A 306
LEU A 314
ILE A 332
VAL A 376
 None
 1.29A 2qd3A-2yeqA:
undetectable		 2qd3A-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 4 VAL A 462
TYR A 131
VAL A 168
SER A 163
 None
None
PE5  A 558 ( 4.8A)
None
 1.40A 2x45B-2yeqA:
0.0		 2x45B-2yeqA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 ARG A 282
ASP A 209
GLU A 155
TYR A 161
 None
CA  A1525 (-3.4A)
None
EDO  A 552 (-4.9A)
 1.31A 2ya7C-2yeqA:
undetectable		 2ya7C-2yeqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 ARG A 282
ASP A 151
ASN A 216
 None
CA  A1525 (-2.4A)
CA  A1526 (-3.3A)
 0.85A 2zzmA-2yeqA:
undetectable		 2zzmA-2yeqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 ARG A 420
ILE A 433
TRP A 337
 None
 1.01A 3e68A-2yeqA:
undetectable		 3e68A-2yeqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ARG A 420
ILE A 433
TRP A 337
PHE A 436
 None
 1.26A 3ej8A-2yeqA:
0.0
3ej8B-2yeqA:
0.0		 3ej8A-2yeqA:
24.82
3ej8B-2yeqA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ARG A 420
ILE A 433
TRP A 337
PHE A 436
 None
 1.23A 3ej8C-2yeqA:
0.0
3ej8D-2yeqA:
0.0		 3ej8C-2yeqA:
24.82
3ej8D-2yeqA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 4 GLN A 330
GLN A 331
GLY A 150
HIS A 148
 None
 1.41A 3huoA-2yeqA:
undetectable		 3huoA-2yeqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 PHE A 393
GLN A 481
PHE A 334
 None
 0.81A 3rv5A-2yeqA:
undetectable		 3rv5A-2yeqA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 TYR A 161
GLU A 212
TYR A 152
 EDO  A 552 (-4.9A)
None
None
 0.94A 3ug8A-2yeqA:
undetectable		 3ug8A-2yeqA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 HIS A 382
HIS A 211
GLU A 503
ASP A 380
 FE  A1524 (-3.4A)
PO4  A1527 (-4.0A)
None
CA  A1525 ( 3.4A)
 1.26A 4blvA-2yeqA:
undetectable		 4blvA-2yeqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 HIS A 510
HIS A 382
SER A 412
ASP A 151
 PO4  A1527 (-4.1A)
FE  A1524 (-3.4A)
FE  A1524 ( 4.0A)
CA  A1525 (-2.4A)
 1.10A 4blvA-2yeqA:
undetectable		 4blvA-2yeqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 HIS A 211
GLU A 223
ASN A 511
 PO4  A1527 (-4.0A)
None
None
 1.03A 4bupB-2yeqA:
undetectable		 4bupB-2yeqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 PHE A 273
PHE A 265
PHE A 119
LEU A 107
 None
EDO  A 535 (-4.7A)
None
None
 1.03A 4ejgA-2yeqA:
undetectable		 4ejgA-2yeqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 LEU A 305
LEU A 306
LEU A 314
ILE A 332
VAL A 376
 None
 1.29A 4f4dA-2yeqA:
undetectable		 4f4dA-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 LEU A 306
LEU A 314
LEU A 318
GLN A 331
VAL A 376
 None
 1.30A 4f4dA-2yeqA:
undetectable		 4f4dA-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 ASP A 289
ASP A 380
GLU A 504
GLU A 223
 None
CA  A1525 ( 3.4A)
EDO  A 540 (-3.7A)
None
 1.10A 4feuD-2yeqA:
undetectable		 4feuD-2yeqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ASP A 289
ASP A 380
GLU A 504
GLU A 223
 None
CA  A1525 ( 3.4A)
EDO  A 540 (-3.7A)
None
 1.17A 4fevB-2yeqA:
undetectable		 4fevB-2yeqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ASP A 289
ASP A 380
GLU A 504
GLU A 223
 None
CA  A1525 ( 3.4A)
EDO  A 540 (-3.7A)
None
 1.22A 4fewB-2yeqA:
undetectable		 4fewB-2yeqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 ASP A 289
ASP A 380
GLU A 504
GLU A 223
 None
CA  A1525 ( 3.4A)
EDO  A 540 (-3.7A)
None
 1.20A 4gkhD-2yeqA:
undetectable		 4gkhD-2yeqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 PRO A 345
ASP A 289
ASP A 350
MET A 349
GLY A 354
 None
 1.50A 4j7xF-2yeqA:
2.8		 4j7xF-2yeqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 LYS A  68
PRO A  69
SER A  70
 PE5  A 580 ( 2.9A)
None
PE5  A 580 ( 3.8A)
 0.48A 4k50I-2yeqA:
undetectable		 4k50I-2yeqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 8 LEU A 305
LEU A 306
LEU A 314
ILE A 332
VAL A 376
 None
 1.31A 4klaA-2yeqA:
undetectable		 4klaA-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 VAL A 376
GLN A 358
LEU A 318
LEU A 276
GLN A 330
 None
 1.13A 4kuoA-2yeqA:
undetectable		 4kuoA-2yeqA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 PHE A 436
ARG A 420
ILE A 433
TRP A 337
 None
 1.20A 4nosA-2yeqA:
undetectable
4nosB-2yeqA:
undetectable		 4nosA-2yeqA:
24.36
4nosB-2yeqA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ARG A 420
ILE A 433
TRP A 337
PHE A 436
 None
 1.34A 4nosC-2yeqA:
undetectable
4nosD-2yeqA:
undetectable		 4nosC-2yeqA:
24.36
4nosD-2yeqA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 6 PHE A 436
ARG A 420
ILE A 433
TRP A 337
 None
 1.24A 4nosC-2yeqA:
undetectable
4nosD-2yeqA:
undetectable		 4nosC-2yeqA:
24.36
4nosD-2yeqA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 PRO A 108
LEU A 107
HIS A 264
 None
None
EDO  A 576 ( 4.3A)
 0.64A 4pevA-2yeqA:
2.2		 4pevA-2yeqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 ALA A  72
HIS A  76
ARG A  28
HIS A 186
 None
 1.02A 5db5A-2yeqA:
undetectable
5db5B-2yeqA:
undetectable		 5db5A-2yeqA:
21.26
5db5B-2yeqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 5 GLN A 125
HIS A 129
ILE A 410
TYR A 135
 None
 1.24A 5dnuA-2yeqA:
undetectable		 5dnuA-2yeqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 5 GLN A 125
HIS A 129
ILE A 410
TYR A 135
 None
 1.22A 5dnvA-2yeqA:
undetectable		 5dnvA-2yeqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 VAL A 406
SER A 384
TRP A 385
 None
 1.01A 5jwaA-2yeqA:
undetectable		 5jwaA-2yeqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 ALA A 271
VAL A 375
GLY A 402
ALA A 403
LEU A 484
 None
 1.04A 5kirB-2yeqA:
undetectable		 5kirB-2yeqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 ASP A 350
HIS A 510
THR A 411
GLN A 125
GLY A 379
 None
PO4  A1527 (-4.1A)
None
None
None
 1.28A 5m54E-2yeqA:
undetectable		 5m54E-2yeqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 LEU A  34
GLY A  36
GLY A  38
ALA A 187
 None
 0.56A 5o96C-2yeqA:
undetectable		 5o96C-2yeqA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 TYR A 281
ASP A 277
LEU A 261
TYR A 239
 None
 1.21A 5ov9B-2yeqA:
undetectable		 5ov9B-2yeqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 ARG A 249
ARG A 263
ASP A  17
 None
None
EDO  A 535 (-3.4A)
 0.70A 6d8pA-2yeqA:
undetectable		 6d8pA-2yeqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ASP A 380
ASP A 209
ARG A 506
GLN A 285
 CA  A1525 ( 3.4A)
CA  A1525 (-3.4A)
PO4  A1527 (-3.9A)
NA  A 577 (-3.3A)
 1.48A 6g31A-2yeqA:
undetectable		 6g31A-2yeqA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ASP A 380
ASP A 209
ARG A 506
GLN A 285
 CA  A1525 ( 3.4A)
CA  A1525 (-3.4A)
PO4  A1527 (-3.9A)
NA  A 577 (-3.3A)
 1.31A 6g31G-2yeqA:
undetectable		 6g31G-2yeqA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 GLY A 166
VAL A 462
ASN A 415
GLN A 126
GLY A 413
 PE5  A 558 ( 3.7A)
None
EDO  A 533 ( 4.7A)
None
EDO  A 552 ( 3.8A)
 1.19A 6gneA-2yeqA:
undetectable		 6gneA-2yeqA:
24.01