SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 7 SER A  85
PRO A  83
ALA A 162
TYR A 175
 None
HIC  A   1 ( 4.8A)
None
HIC  A   1 (-4.7A)
 1.02A 1k5qA-2yetA:
undetectable
1k5qB-2yetA:
undetectable		 1k5qA-2yetA:
23.83
1k5qB-2yetA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		5 / 12 LEU A 181
GLY A 187
GLY A 185
ILE A 145
LEU A 109
 None
 1.09A 1p91B-2yetA:
undetectable		 1p91B-2yetA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		5 / 12 GLN A  50
ASP A 105
PRO A  52
GLY A 196
LEU A 199
 None
 1.30A 2nv4A-2yetA:
undetectable		 2nv4A-2yetA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 5 LEU A  41
GLN A   5
THR A  36
HIS A  57
 HIC  A   1 ( 4.9A)
None
None
None
 1.30A 2zj0B-2yetA:
undetectable		 2zj0B-2yetA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 5 LEU A  41
GLN A   5
THR A  36
HIS A  57
 HIC  A   1 ( 4.9A)
None
None
None
 1.34A 2zj0C-2yetA:
undetectable		 2zj0C-2yetA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 5 LEU A  41
GLN A   5
THR A  36
HIS A  57
 HIC  A   1 ( 4.9A)
None
None
None
 1.32A 3ce6B-2yetA:
undetectable		 3ce6B-2yetA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 7 GLN A 173
PRO A 176
GLN A 177
GLU A 159
 CU  A 301 ( 4.5A)
None
None
None
 1.10A 3l2vA-2yetA:
undetectable		 3l2vA-2yetA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 8 GLY A  46
PRO A 176
GLN A 177
GLU A 159
 None
 0.96A 3s3mA-2yetA:
undetectable		 3s3mA-2yetA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 8 GLY A  46
PRO A 176
GLN A 177
GLU A 159
 None
 0.97A 3s3nA-2yetA:
undetectable		 3s3nA-2yetA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 7 ILE A  91
GLU A 159
TYR A 200
HIS A 201
 None
 0.94A 4a97A-2yetA:
undetectable		 4a97A-2yetA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 7 ILE A  91
GLU A 159
TYR A 200
HIS A 201
 None
 1.01A 4a97H-2yetA:
undetectable		 4a97H-2yetA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 6 PHE A 112
LEU A 199
GLY A 222
TYR A  49
 None
 0.79A 5x5qE-2yetA:
undetectable		 5x5qE-2yetA:
23.49