SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 4 HIS A 739
LEU A 217
LEU A 161
LEU A 565
 5PL  A 900 ( 4.8A)
5PL  A 900 ( 4.9A)
None
None
 1.23A 1a4lD-2yevA:
undetectable		 1a4lD-2yevA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 GLY A 397
TYR A 260
PHE A  36
PHE A  81
 None
 0.95A 1ax9A-2yevA:
3.2		 1ax9A-2yevA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 6 TYR A 194
GLY A 262
GLY A 401
TYR A 404
 None
 0.73A 1eswA-2yevA:
undetectable		 1eswA-2yevA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 THR A 335
ILE A 263
GLY A 262
ILE A 332
VAL A 198
 None
 0.76A 1nv8B-2yevA:
undetectable		 1nv8B-2yevA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 4 HIS A 736
VAL A 733
THR A 664
LEU A 657
 None
 1.33A 1oq5A-2yevA:
undetectable		 1oq5A-2yevA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 4 HIS A 736
VAL A 733
THR A 664
LEU A 659
 None
 1.48A 1oq5A-2yevA:
undetectable		 1oq5A-2yevA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.34A 1q23C-2yevB:
undetectable		 1q23C-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 10 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.38A 1q23E-2yevB:
undetectable		 1q23E-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.34A 1q23F-2yevB:
undetectable		 1q23F-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.33A 1q23I-2yevB:
undetectable		 1q23I-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.36A 1q23J-2yevB:
undetectable		 1q23J-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 10 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.36A 1q23K-2yevB:
undetectable		 1q23K-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.35A 1q23L-2yevB:
undetectable		 1q23L-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.65A 1rjoA-2yevA:
undetectable		 1rjoA-2yevA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.66A 1rkyA-2yevA:
undetectable		 1rkyA-2yevA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 11 ILE A 742
GLY A 743
GLY A 744
ILE A 697
VAL A 594
 5PL  A 900 (-4.3A)
None
None
None
None
 0.99A 1sduA-2yevA:
undetectable		 1sduA-2yevA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 THR A 335
ILE A 263
GLY A 262
ILE A 332
VAL A 198
 None
 0.80A 1sg9B-2yevA:
undetectable		 1sg9B-2yevA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ARG A 447
HIS A 387
PHE A 386
ILE A  49
 HAS  A1016 ( 3.1A)
HAS  A1015 (-3.2A)
HAS  A1016 ( 4.1A)
HAS  A1015 (-4.1A)
 1.33A 1tdnA-2yevA:
undetectable		 1tdnA-2yevA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 ARG A 448
ARG A 447
ILE A  49
 HAS  A1015 (-3.9A)
HAS  A1016 ( 3.1A)
HAS  A1015 (-4.1A)
 0.78A 1uobA-2yevA:
undetectable		 1uobA-2yevA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 1v54A-2yevA:
55.3		 1v54A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.21A 1v54N-2yevA:
55.2		 1v54N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.20A 1v55A-2yevA:
55.0		 1v55A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 1v55N-2yevA:
55.0		 1v55N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 THR A 335
ILE A 263
GLY A 262
ILE A 332
VAL A 198
 None
 0.82A 1vq1B-2yevA:
undetectable		 1vq1B-2yevA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.69A 1w2zA-2yevA:
undetectable		 1w2zA-2yevA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.69A 1w2zB-2yevA:
undetectable		 1w2zB-2yevA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.68A 1w2zC-2yevA:
undetectable		 1w2zC-2yevA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.67A 1w2zD-2yevA:
undetectable		 1w2zD-2yevA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 5 LEU A 209
LEU A 212
LEU A 161
LEU A 163
 None
 0.89A 2ab2B-2yevA:
undetectable		 2ab2B-2yevA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 LEU A 168
LEU A 206
GLY A 630
ALA A 210
ALA A 214
 None
 1.19A 2bm9C-2yevA:
undetectable		 2bm9C-2yevA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 6 LEU A 747
ALA A 677
HIS A 775
ASP A 778
 None
 1.37A 2dpzA-2yevA:
undetectable		 2dpzA-2yevA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.15A 2dyrA-2yevA:
55.3		 2dyrA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.22A 2dyrN-2yevA:
55.2		 2dyrN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 2dysA-2yevA:
55.2		 2dysA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.20A 2dysN-2yevA:
55.2		 2dysN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.14A 2eijA-2yevA:
55.0		 2eijA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.17A 2eijN-2yevA:
55.0		 2eijN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.09A 2eikA-2yevA:
55.0		 2eikA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.24A 2eikN-2yevA:
55.0		 2eikN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 2eilA-2yevA:
55.2		 2eilA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.22A 2eilN-2yevA:
55.1		 2eilN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.24A 2eimA-2yevA:
54.7		 2eimA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.26A 2eimN-2yevA:
54.7		 2eimN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.14A 2einA-2yevA:
55.0		 2einA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.35A 2einN-2yevA:
55.0		 2einN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.23A 2iwkA-2yevB:
8.5		 2iwkA-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.16A 2iwkA-2yevB:
8.5		 2iwkA-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.21A 2iwkB-2yevB:
8.4		 2iwkB-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.16A 2iwkB-2yevB:
8.4		 2iwkB-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 5 PRO A 407
TYR A 404
TYR A 403
PRO A 346
 None
 1.43A 2ombA-2yevA:
undetectable
2ombB-2yevA:
undetectable		 2ombA-2yevA:
14.27
2ombB-2yevA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.63A 2oqeA-2yevA:
undetectable		 2oqeA-2yevA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.63A 2oqeB-2yevA:
undetectable		 2oqeB-2yevA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.63A 2oqeC-2yevA:
undetectable		 2oqeC-2yevA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.61A 2oqeD-2yevA:
undetectable		 2oqeD-2yevA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.62A 2oqeF-2yevA:
undetectable		 2oqeF-2yevA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 THR A 294
VAL C  14
THR C  15
VAL A 626
 None
 0.95A 2qbmA-2yevA:
undetectable		 2qbmA-2yevA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 ILE B 183
PHE B  31
ALA B 170
ARG A 447
GLU B 199
 None
None
None
HAS  A1016 ( 3.1A)
MG  A1801 ( 2.6A)
 1.20A 2v0mD-2yevB:
undetectable		 2v0mD-2yevB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 LEU A 440
MET A 445
MET A 366
 None
None
4AG  A1200 (-3.3A)
 0.85A 2vavF-2yevA:
undetectable		 2vavF-2yevA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.65A 2w0qA-2yevA:
undetectable		 2w0qA-2yevA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.65A 2w0qB-2yevA:
undetectable		 2w0qB-2yevA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 GLY A 164
ILE A  83
ASN A 205
ALA A 116
 None
 0.94A 2x0pA-2yevA:
undetectable		 2x0pA-2yevA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 LEU C  43
VAL C  39
VAL A 733
PHE A 703
ASN A 663
 None
 1.19A 2y00A-2yevC:
undetectable		 2y00A-2yevC:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 LEU C  43
VAL C  39
VAL A 733
PHE A 703
ASN A 663
 None
 1.20A 2y00B-2yevC:
undetectable		 2y00B-2yevC:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 LEU C  43
VAL C  39
VAL A 733
PHE A 703
ASN A 663
 None
 1.21A 2y01B-2yevC:
undetectable		 2y01B-2yevC:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.08A 2y69A-2yevA:
55.3		 2y69A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.04A 2y69N-2yevA:
55.2		 2y69N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.17A 2zxwA-2yevA:
55.1		 2zxwA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 2zxwN-2yevA:
55.1		 2zxwN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.20A 3abkA-2yevA:
55.0		 3abkA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.11A 3abkN-2yevA:
55.0		 3abkN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 3ablA-2yevA:
55.2		 3ablA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.20A 3ablN-2yevA:
55.2		 3ablN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 3abmA-2yevA:
55.2		 3abmA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.00A 3abmN-2yevA:
55.2		 3abmN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 3ag1A-2yevA:
54.5		 3ag1A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 3ag1N-2yevA:
54.5		 3ag1N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.11A 3ag2A-2yevA:
55.2		 3ag2A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 3ag2N-2yevA:
55.2		 3ag2N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 3ag3A-2yevA:
54.9		 3ag3A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 3ag3N-2yevA:
55.0		 3ag3N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.33A 3ag4A-2yevA:
54.7		 3ag4A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.26A 3ag4N-2yevA:
54.7		 3ag4N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.00A 3asnA-2yevA:
55.3		 3asnA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.12A 3asnN-2yevA:
55.3		 3asnN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.00A 3asoA-2yevA:
55.3		 3asoA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.11A 3asoN-2yevA:
55.3		 3asoN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 VAL A 290
VAL A 291
GLY A 293
PRO A 251
 None
 0.94A 3bjwC-2yevA:
1.0		 3bjwC-2yevA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.40A 3bvdA-2yevA:
37.9		 3bvdA-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 9 PHE A 704
VAL A 740
GLY A 743
ILE A 748
GLY A 700
 None
 1.18A 3csjB-2yevA:
undetectable		 3csjB-2yevA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 VAL B 144
PHE B 223
VAL B 213
THR B 273
VAL B 326
 None
 1.16A 3czvA-2yevB:
undetectable
3czvB-2yevB:
undetectable		 3czvA-2yevB:
23.69
3czvB-2yevB:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 PHE B 337
GLY B  28
VAL B 166
ALA B 147
LEU B 143
 None
 1.19A 3dh0A-2yevB:
undetectable		 3dh0A-2yevB:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.15A 3dtuA-2yevA:
57.2		 3dtuA-2yevA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.44A 3dtuB-2yevB:
17.1		 3dtuB-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.17A 3dtuB-2yevB:
17.1		 3dtuB-2yevB:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 3dtuC-2yevA:
57.4		 3dtuC-2yevA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.17A 3dtuD-2yevB:
17.0		 3dtuD-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.46A 3dtuD-2yevB:
17.0		 3dtuD-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 ASN B  32
MET A 369
PHE B  39
 None
HAS  A1016 ( 4.8A)
None
 0.86A 3g4lD-2yevB:
undetectable		 3g4lD-2yevB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.56A 3hiiA-2yevA:
undetectable		 3hiiA-2yevA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.56A 3hiiB-2yevA:
undetectable		 3hiiB-2yevA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 4 GLY A 235
ASP A 237
GLY A 638
THR A 731
 None
 1.03A 3k4vC-2yevA:
undetectable		 3k4vC-2yevA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 GLY A  86
GLY A 397
PHE A  80
PHE A 117
 None
 0.95A 3ko0M-2yevA:
undetectable
3ko0P-2yevA:
undetectable		 3ko0M-2yevA:
7.26
3ko0P-2yevA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC8_0
(GRAMICIDIN D)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 4 VAL B  22
TRP B 165
VAL B 166
TRP A 459
 None
 1.32A 3l8lC-2yevB:
undetectable
3l8lD-2yevB:
undetectable		 3l8lC-2yevB:
5.22
3l8lD-2yevB:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 TYR A 254
SER A 208
ALA A 201
LEU A  87
LEU A 206
 HAS  A1016 (-4.4A)
None
None
None
None
 1.37A 3lcvB-2yevA:
undetectable		 3lcvB-2yevA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 717
PHE A 729
PHE A 730
 None
 0.55A 3lk0D-2yevA:
undetectable		 3lk0D-2yevA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 LEU B 145
ILE B 183
GLY B 171
ALA B 170
LEU B 169
 None
 1.08A 3n8xB-2yevB:
undetectable		 3n8xB-2yevB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 6 LEU A 644
TYR A 641
ARG A 643
LEU C  58
 None
 1.12A 3rd0A-2yevA:
4.0		 3rd0A-2yevA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.33A 3s33A-2yevA:
37.9		 3s33A-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.44A 3s38A-2yevA:
37.6		 3s38A-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.32A 3s39A-2yevA:
37.9		 3s39A-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.35A 3s3aA-2yevA:
37.2		 3s3aA-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.33A 3s3bA-2yevA:
38.1		 3s3bA-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.40A 3s3cA-2yevA:
37.9		 3s3cA-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.32A 3s3dA-2yevA:
37.9		 3s3dA-2yevA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 ASP B 293
GLY B 296
PRO B 307
GLN B 308
 None
 1.03A 3s3nA-2yevB:
undetectable		 3s3nA-2yevB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 LEU A 635
PHE A 245
THR A 252
ILE A  83
ILE A 160
 None
 1.25A 3sp9A-2yevA:
undetectable		 3sp9A-2yevA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.37A 3u9fB-2yevB:
undetectable
3u9fC-2yevB:
undetectable		 3u9fB-2yevB:
20.23
3u9fC-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 10 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.38A 3u9fE-2yevB:
undetectable		 3u9fE-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 10 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.43A 3u9fD-2yevB:
0.0
3u9fF-2yevB:
0.0		 3u9fD-2yevB:
20.23
3u9fF-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.38A 3u9fH-2yevB:
undetectable
3u9fI-2yevB:
undetectable		 3u9fH-2yevB:
20.23
3u9fI-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 10 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.35A 3u9fI-2yevB:
undetectable		 3u9fI-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.42A 3u9fJ-2yevB:
undetectable
3u9fK-2yevB:
undetectable		 3u9fJ-2yevB:
20.23
3u9fK-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 10 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.42A 3u9fK-2yevB:
undetectable		 3u9fK-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.39A 3u9fN-2yevB:
undetectable
3u9fO-2yevB:
undetectable		 3u9fN-2yevB:
20.23
3u9fO-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.38A 3u9fM-2yevB:
undetectable
3u9fO-2yevB:
undetectable		 3u9fM-2yevB:
20.23
3u9fO-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 9 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.42A 3u9fP-2yevB:
undetectable		 3u9fP-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.31A 3u9fP-2yevB:
undetectable
3u9fS-2yevB:
undetectable		 3u9fP-2yevB:
20.23
3u9fS-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 PHE A 624
PHE A 165
THR A 213
PHE A 589
ALA A 590
 5PL  A 900 (-3.7A)
5PL  A 900 (-4.1A)
None
None
5PL  A 900 ( 3.9A)
 1.21A 3ua1A-2yevA:
0.0		 3ua1A-2yevA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 4 PRO A 407
LEU A 402
HIS A 422
LEU A 425
 None
 0.82A 3vw7A-2yevA:
6.7		 3vw7A-2yevA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.09A 3wg7A-2yevA:
55.0		 3wg7A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 3wg7N-2yevA:
55.1		 3wg7N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 380
THR A 451
TYR A 449
TRP A 459
 HAS  A1015 (-4.9A)
None
None
None
 1.43A 3wipB-2yevA:
undetectable
3wipC-2yevA:
undetectable		 3wipB-2yevA:
13.22
3wipC-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 TYR A 442
THR A 363
TYR B  43
MET A 369
 4AG  A1200 (-3.5A)
None
None
HAS  A1016 ( 4.8A)
 1.44A 3wipB-2yevA:
undetectable
3wipC-2yevA:
undetectable		 3wipB-2yevA:
13.22
3wipC-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 380
THR A 451
TYR A 449
TRP A 459
 HAS  A1015 (-4.9A)
None
None
None
 1.44A 3wipC-2yevA:
undetectable
3wipD-2yevA:
undetectable		 3wipC-2yevA:
13.22
3wipD-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 TYR A 442
THR A 363
TYR B  43
MET A 369
 4AG  A1200 (-3.5A)
None
None
HAS  A1016 ( 4.8A)
 1.45A 3wipC-2yevA:
undetectable
3wipD-2yevA:
undetectable		 3wipC-2yevA:
13.22
3wipD-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TRP A 459
TYR A 380
THR A 451
TYR A 449
 None
HAS  A1015 (-4.9A)
None
None
 1.42A 3wipA-2yevA:
undetectable
3wipE-2yevA:
undetectable		 3wipA-2yevA:
13.22
3wipE-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 MET A 369
TYR A 442
THR A 363
TYR B  43
 HAS  A1016 ( 4.8A)
4AG  A1200 (-3.5A)
None
None
 1.49A 3wipA-2yevA:
undetectable
3wipE-2yevA:
undetectable		 3wipA-2yevA:
13.22
3wipE-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 3x2qA-2yevA:
55.2		 3x2qA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.10A 3x2qN-2yevA:
55.2		 3x2qN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 6 GLY A 235
LEU A 724
ASN A 723
GLU A 722
 None
 0.98A 3zqtA-2yevA:
undetectable		 3zqtA-2yevA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 TYR A 194
VAL A 195
ASN A 516
VAL A 175
 None
 0.78A 4e1gB-2yevA:
undetectable		 4e1gB-2yevA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ASN A 356
GLY A 360
THR A 363
LEU A 435
 None
None
None
4AG  A1200 ( 4.2A)
 0.68A 4ejjD-2yevA:
undetectable		 4ejjD-2yevA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 LEU A 504
ALA A 101
ASP A 103
VAL A  95
 None
 0.93A 4eyrA-2yevA:
undetectable		 4eyrA-2yevA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 248
ASN A 205
PHE A 207
SER A 208
 None
 0.98A 4eyzA-2yevA:
undetectable		 4eyzA-2yevA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 248
ASN A 205
PHE A 207
SER A 208
 None
 0.98A 4eyzB-2yevA:
undetectable		 4eyzB-2yevA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 10 PHE A 165
ALA A 158
LEU A 161
GLY A 164
ALA A 728
 5PL  A 900 (-4.1A)
None
None
None
None
 1.27A 4fe1A-2yevA:
0.0
4fe1J-2yevA:
undetectable		 4fe1A-2yevA:
24.18
4fe1J-2yevA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 TRP B  41
PHE B  44
PHE B  45
LEU B  51
VAL B  52
 None
 0.86A 4ib4A-2yevB:
3.1		 4ib4A-2yevB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 LEU A 662
TRP A 781
TYR A 789
ASP A 778
GLY A 700
 None
 1.36A 4j7xF-2yevA:
undetectable		 4j7xF-2yevA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ALA B 170
GLY B 171
GLY A 444
ASN B  32
HIS B  26
 None
 1.06A 4jlgA-2yevB:
undetectable		 4jlgA-2yevB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 143
TRP A 229
LEU A 724
LEU A 642
 None
 1.09A 4jtrA-2yevA:
undetectable		 4jtrA-2yevA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 VAL B 149
ILE B 113
GLY B 115
ALA B 116
LEU B 135
 None
 0.96A 4o1zA-2yevB:
undetectable		 4o1zA-2yevB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 ASP A  17
VAL A  14
ASP A  23
LEU A  29
PHE A  93
 None
None
None
7E8  A1300 (-4.7A)
None
 1.38A 4pevC-2yevA:
undetectable		 4pevC-2yevA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 ALA B 203
GLY A 133
GLY A 132
SER A 151
SER A 149
 None
 0.93A 4qvwK-2yevB:
undetectable
4qvwL-2yevB:
undetectable		 4qvwK-2yevB:
20.76
4qvwL-2yevB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 ALA B 203
GLY A 133
GLY A 132
SER A 151
SER A 149
 None
 0.94A 4qvwY-2yevB:
undetectable
4qvwZ-2yevB:
undetectable		 4qvwY-2yevB:
20.76
4qvwZ-2yevB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 10 LEU C  58
LEU A 724
ALA A 728
ALA A 647
GLY A 638
 None
 1.41A 4rn6A-2yevC:
undetectable		 4rn6A-2yevC:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 GLY B 195
VAL B  22
PHE A 376
ILE B  24
 None
 1.16A 4xv2B-2yevB:
undetectable		 4xv2B-2yevB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 9 PHE A 165
ALA A 158
LEU A 161
GLY A 164
PHE A 711
 5PL  A 900 (-4.1A)
None
None
None
None
 1.40A 4y28A-2yevA:
4.6
4y28J-2yevA:
0.0		 4y28A-2yevA:
23.35
4y28J-2yevA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 478
GLY A 476
GLY A 477
 None
None
None
HAS  A1015 ( 3.7A)
 0.86A 5a06A-2yevA:
undetectable		 5a06A-2yevA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 478
GLY A 476
GLY A 477
 None
None
None
HAS  A1015 ( 3.7A)
 0.85A 5a06C-2yevA:
undetectable		 5a06C-2yevA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 478
GLY A 476
GLY A 477
 None
None
None
HAS  A1015 ( 3.7A)
 0.85A 5a06F-2yevA:
undetectable		 5a06F-2yevA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.10A 5b1aA-2yevA:
55.3		 5b1aA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.21A 5b1aN-2yevA:
55.4		 5b1aN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.13A 5b1bA-2yevA:
55.0		 5b1bA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 5b1bN-2yevA:
55.1		 5b1bN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.12A 5b3sA-2yevA:
55.3		 5b3sA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.20A 5b3sN-2yevA:
55.3		 5b3sN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 10 THR A 731
LEU A 217
PHE A 165
LEU A 631
LEU A 635
 None
5PL  A 900 ( 4.9A)
5PL  A 900 (-4.1A)
None
None
 1.18A 5fhzC-2yevA:
undetectable		 5fhzC-2yevA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 GLY A 395
SER A 394
MET A 256
GLY A  74
HIS A 387
 None
HAS  A1016 (-3.7A)
None
HAS  A1015 (-3.7A)
HAS  A1015 (-3.2A)
 1.20A 5hikA-2yevA:
undetectable		 5hikA-2yevA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 ILE A 160
ALA A 159
TYR A 156
GLY A 211
GLY A 164
 None
 1.35A 5i71A-2yevA:
0.0		 5i71A-2yevA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 ILE B 161
ALA A 214
ALA A 215
VAL A 219
GLY A 638
 None
 0.74A 5igjA-2yevB:
undetectable		 5igjA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ILE B 161
ALA A 214
ALA A 215
VAL A 219
GLY A 638
 None
 0.71A 5igtA-2yevB:
undetectable		 5igtA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ILE B 161
ALA A 214
ALA A 215
VAL A 219
TYR A 641
 None
 0.73A 5igtA-2yevB:
undetectable		 5igtA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.15A 5iy5A-2yevA:
55.2		 5iy5A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 5iy5N-2yevA:
55.2		 5iy5N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 5 ILE A 263
PHE A 353
SER A 394
ALA A 400
 None
None
HAS  A1016 (-3.7A)
None
 1.09A 5msdA-2yevA:
undetectable		 5msdA-2yevA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 LEU A 257
PHE A 353
LEU A 329
ILE A 332
 HAS  A1016 ( 3.9A)
None
None
None
 0.84A 5mzjA-2yevA:
8.9		 5mzjA-2yevA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 LYS A 190
TRP A 196
SER A 187
 None
 1.34A 5nwwA-2yevA:
undetectable		 5nwwA-2yevA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 ASN A 171
PHE A 174
TRP A 623
TYR A 179
 None
 1.49A 5oh1C-2yevA:
undetectable		 5oh1C-2yevA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.80A 5sxqA-2yevB:
undetectable		 5sxqA-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.85A 5sxqB-2yevB:
undetectable		 5sxqB-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.80A 5sxtA-2yevB:
undetectable		 5sxtA-2yevB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.83A 5sxtB-2yevB:
undetectable		 5sxtB-2yevB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.85A 5syjA-2yevB:
undetectable		 5syjA-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 8 GLU B 142
VAL B 144
GLY B 332
LEU B 334
 None
 0.85A 5syjB-2yevB:
undetectable		 5syjB-2yevB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 402
THR A 345
ARG A 412
 None
 1.00A 5vc0A-2yevA:
undetectable		 5vc0A-2yevA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 PHE A 624
PHE A 165
THR A 213
PHE A 589
ALA A 590
 5PL  A 900 (-3.7A)
5PL  A 900 (-4.1A)
None
None
5PL  A 900 ( 3.9A)
 1.21A 5vcgA-2yevA:
undetectable		 5vcgA-2yevA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 5w97a-2yevA:
54.8		 5w97a-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.13A 5waua-2yevA:
55.3		 5waua-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 5x19A-2yevA:
54.6		 5x19A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.21A 5x19N-2yevA:
54.7		 5x19N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 5x1bA-2yevA:
54.1		 5x1bA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.10A 5x1bN-2yevA:
54.0		 5x1bN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.21A 5x1fA-2yevA:
54.7		 5x1fA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 5x1fN-2yevA:
54.7		 5x1fN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.04A 5xdqA-2yevA:
55.4		 5xdqA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.13A 5xdqN-2yevA:
55.4		 5xdqN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.05A 5xdxA-2yevA:
55.1		 5xdxA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.04A 5xdxN-2yevA:
55.1		 5xdxN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 GLY A 361
GLY A 364
LEU A 264
ASN A 388
PHE A 353
 HAS  A1016 (-3.3A)
HAS  A1016 (-3.7A)
None
None
None
 1.10A 5ybbA-2yevA:
undetectable		 5ybbA-2yevA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 5z84A-2yevA:
55.3		 5z84A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.20A 5z84N-2yevA:
55.4		 5z84N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.21A 5z85A-2yevA:
55.3		 5z85A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 5z85N-2yevA:
55.4		 5z85N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.00A 5z86A-2yevA:
55.3		 5z86A-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 5z86N-2yevA:
55.4		 5z86N-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.18A 5zcoA-2yevA:
55.3		 5zcoA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.13A 5zcoN-2yevA:
55.4		 5zcoN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.11A 5zcpA-2yevA:
55.3		 5zcpA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.22A 5zcpN-2yevA:
55.4		 5zcpN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.11A 5zcqA-2yevA:
55.4		 5zcqA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.14A 5zcqN-2yevA:
55.4		 5zcqN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 10 PHE A 247
GLY A 638
ILE C  46
ALA C  50
PHE A 199
 None
 1.40A 5zjiA-2yevA:
1.4
5zjiJ-2yevA:
undetectable		 5zjiA-2yevA:
7.38
5zjiJ-2yevA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 VAL B  60
VAL B  53
GLY B  55
PHE A 355
VAL A 350
 None
 0.94A 6a94B-2yevB:
undetectable		 6a94B-2yevB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 PHE A 244
PHE A 247
ALA A 727
ILE C  46
LEU A 635
 None
 1.24A 6aybA-2yevA:
undetectable		 6aybA-2yevA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 MET A 191
VAL A  94
VAL A  95
LEU A 521
THR A 508
 None
 1.23A 6b52A-2yevA:
undetectable		 6b52A-2yevA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 HIS A  24
VAL A  22
LEU A 504
PHE A 517
ALA A 101
 None
 1.03A 6c2mA-2yevA:
undetectable		 6c2mA-2yevA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 ALA A 754
PHE A 589
THR A 766
LEU A 767
ALA A 770
 None
None
5PL  A 900 (-2.8A)
None
5PL  A 900 ( 4.3A)
 1.00A 6djzC-2yevA:
undetectable		 6djzC-2yevA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 11 ASP A 778
VAL A 668
SER A 671
VAL A 783
VAL C  39
 None
 1.34A 6dryA-2yevA:
2.0		 6dryA-2yevA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.64A 6giqa-2yevA:
47.3		 6giqa-2yevA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.14A 6hu9a-2yevA:
52.6		 6hu9a-2yevA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.24A 6hu9m-2yevA:
52.5		 6hu9m-2yevA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.12A 6nknA-2yevA:
54.5		 6nknA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.14A 6nknN-2yevA:
54.3		 6nknN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.16A 6nmfA-2yevA:
54.1		 6nmfA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.19A 6nmfN-2yevA:
54.0		 6nmfN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.10A 6nmpA-2yevA:
54.4		 6nmpA-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.17A 6nmpN-2yevA:
54.3		 6nmpN-2yevA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 6 LEU A 390
HIS A 300
HIS A 299
TYR A 254
 HAS  A1015 ( 3.6A)
CU  A1017 ( 3.1A)
CU  A1017 ( 3.3A)
HAS  A1016 (-4.4A)
 0.98A 6pahA-2yevA:
undetectable		 6pahA-2yevA:
16.39