SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 VAL A 139
TYR A 192
TYR A 164
LEU A 189
 None
 0.84A 1z2bB-2yf0A:
undetectable		 1z2bB-2yf0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 ASN A 329
TYR A 192
SER A 331
 None
 0.85A 2gvcB-2yf0A:
undetectable		 2gvcB-2yf0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 ASN A 329
TYR A 192
SER A 331
 None
 0.80A 2gvcE-2yf0A:
undetectable		 2gvcE-2yf0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 7 GLU A 381
PRO A 395
ARG A 382
GLY A 384
 None
 1.13A 2hs1B-2yf0A:
undetectable		 2hs1B-2yf0A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 SER A 344
GLU A 369
ASP A 129
 None
 0.75A 2zulA-2yf0A:
undetectable		 2zulA-2yf0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 GLU A  57
SER A  55
GLN A  71
VAL A  12
 None
 0.93A 3b9lA-2yf0A:
undetectable		 3b9lA-2yf0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 SER A 344
GLU A 369
ASP A 129
 None
 0.74A 3dmhA-2yf0A:
undetectable		 3dmhA-2yf0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 SER A 337
ASP A 238
ASP A 341
 SO4  A1506 (-4.3A)
None
SO4  A1506 (-4.3A)
 0.89A 3iv6A-2yf0A:
undetectable		 3iv6A-2yf0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 SER A 337
ASP A 238
ASP A 341
 SO4  A1506 (-4.3A)
None
SO4  A1506 (-4.3A)
 0.93A 3iv6C-2yf0A:
undetectable		 3iv6C-2yf0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 ASN A 150
ALA A 149
LYS A 154
 None
 0.79A 3runA-2yf0A:
undetectable		 3runA-2yf0A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A 287
GLY A 289
LYS A 291
 None
 0.69A 4k50A-2yf0A:
undetectable		 4k50A-2yf0A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A 287
GLY A 289
LYS A 291
 None
 0.63A 4k50E-2yf0A:
0.7		 4k50E-2yf0A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 LYS A 250
GLY A 254
SER A 208
LEU A 207
 None
 1.12A 5bphA-2yf0A:
undetectable		 5bphA-2yf0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 7 LYS A 250
GLY A 254
SER A 208
LEU A 207
 None
 0.96A 5bphB-2yf0A:
undetectable		 5bphB-2yf0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 LYS A 250
GLY A 254
SER A 208
LEU A 207
 None
 1.13A 5bphD-2yf0A:
undetectable		 5bphD-2yf0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A 334
GLN A 345
CYH A 347
 None
 0.77A 5icxA-2yf0A:
undetectable
5icxE-2yf0A:
undetectable		 5icxA-2yf0A:
18.90
5icxE-2yf0A:
3.16