SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		3 / 3 MET A 148
LEU A 151
SER A 152
 None
 0.36A 1ee2A-2yfbA:
undetectable		 1ee2A-2yfbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		4 / 6 ALA A 262
LYS A 266
ASP A 269
ALA A 270
 None
 0.45A 1iwhA-2yfbA:
2.8		 1iwhA-2yfbA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		7 / 7 MET A 137
ASP A 138
ARG A 183
VAL A 186
ARG A 187
ILE A 190
TYR A 236
 ACT  A 501 (-3.8A)
ACT  A 501 (-3.9A)
ACT  A 501 (-3.9A)
ACT  A 501 (-4.4A)
ACT  A 501 (-3.7A)
None
ACT  A 501 (-4.5A)
 0.01A 2yfbA-2yfbA:
33.1		 2yfbA-2yfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		6 / 6 ASP A 138
ARG A 183
VAL A 186
ARG A 187
ILE A 190
TYR A 236
 ACT  A 501 (-3.9A)
ACT  A 501 (-3.9A)
ACT  A 501 (-4.4A)
ACT  A 501 (-3.7A)
None
ACT  A 501 (-4.5A)
 0.24A 2yfbB-2yfbA:
30.5		 2yfbB-2yfbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		5 / 12 ALA A  62
LEU A  83
LEU A  56
LEU A 120
MET A 123
 None
 1.09A 3hm1A-2yfbA:
undetectable		 3hm1A-2yfbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		5 / 11 GLN A 218
ASP A 213
LEU A 209
VAL A 233
ALA A 232
 None
 1.30A 3n23C-2yfbA:
undetectable		 3n23C-2yfbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		3 / 3 TYR A 169
ARG A 176
SER A 173
 None
 1.11A 4khpI-2yfbA:
undetectable
4khpJ-2yfbA:
undetectable		 4khpI-2yfbA:
19.83
4khpJ-2yfbA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		3 / 3 PHE A 243
ASP A 245
LEU A 234
 None
 0.71A 5uhbC-2yfbA:
3.4		 5uhbC-2yfbA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER
(Pseudomonas
putida) 		3 / 3 PHE A 243
ASP A 245
LEU A 234
 None
 0.60A 5uhcC-2yfbA:
2.9		 5uhcC-2yfbA:
12.70