SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 7 GLN A 290
ILE A 293
ARG A 281
TYR A 285
 None
 1.21A 1e72M-2yfkA:
undetectable		 1e72M-2yfkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 VAL A 377
VAL A  38
ILE A 372
MET A 170
 None
 1.14A 1iepA-2yfkA:
undetectable		 1iepA-2yfkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		3 / 3 PHE A  58
ARG A  49
ASN A  83
 None
 0.75A 1xzxX-2yfkA:
undetectable		 1xzxX-2yfkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		3 / 3 PHE A  58
ARG A 394
ASN A  83
 None
 0.67A 1xzxX-2yfkA:
undetectable		 1xzxX-2yfkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 LEU A 176
MET A 215
GLU A 360
MET A 328
 None
 1.12A 2kuhA-2yfkA:
undetectable		 2kuhA-2yfkA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		3 / 3 ARG A 153
GLU A  21
GLN A 142
 None
 0.90A 2p16A-2yfkA:
undetectable		 2p16A-2yfkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 186
ILE A 177
LEU A 176
VAL A 222
PHE A  39
 None
 1.29A 2qo6A-2yfkA:
undetectable		 2qo6A-2yfkA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		3 / 3 LEU A 214
MET A 215
MET A 233
 None
 1.04A 2vavF-2yfkA:
undetectable		 2vavF-2yfkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 VAL A 377
VAL A  38
ILE A 372
MET A 170
 None
 1.10A 3k5vB-2yfkA:
undetectable		 3k5vB-2yfkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 VAL A 377
VAL A  38
ILE A 372
MET A 170
 None
 1.12A 3ms9A-2yfkA:
undetectable		 3ms9A-2yfkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 7 VAL A 377
VAL A  38
ILE A 372
MET A 170
 None
 1.11A 3ms9B-2yfkA:
undetectable		 3ms9B-2yfkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		5 / 11 GLU A 299
LEU A 300
ASN A 304
SER A 302
LEU A 296
 None
 1.39A 3ndvC-2yfkA:
undetectable
3ndvD-2yfkA:
undetectable		 3ndvC-2yfkA:
22.72
3ndvD-2yfkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		5 / 11 LEU A 296
GLU A 299
LEU A 300
ASN A 304
SER A 302
 None
 1.41A 3ndvC-2yfkA:
undetectable
3ndvD-2yfkA:
undetectable		 3ndvC-2yfkA:
22.72
3ndvD-2yfkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 PHE A 373
THR A  44
ALA A 369
ALA A 370
 None
 1.17A 3ns1C-2yfkA:
undetectable		 3ns1C-2yfkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		3 / 3 ASP A  43
GLU A   6
SER A 362
 None
 0.78A 3p2kA-2yfkA:
4.3		 3p2kA-2yfkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 4 VAL A 349
THR A 313
GLU A 314
GLU A 315
 None
 1.42A 4l78A-2yfkA:
undetectable		 4l78A-2yfkA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 156
SER A 138
LEU A  92
ALA A 109
SER A 113
 None
 1.08A 4rrwC-2yfkA:
undetectable		 4rrwC-2yfkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 156
SER A 138
LEU A  92
ALA A 109
SER A 113
 None
 1.08A 4rrzC-2yfkA:
undetectable		 4rrzC-2yfkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 7 HIS A 307
TRP A 272
THR A 254
TRP A 310
 None
 1.46A 4tzuB-2yfkA:
0.0
4tzuC-2yfkA:
0.0		 4tzuB-2yfkA:
14.68
4tzuC-2yfkA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 LEU A  85
LEU A  48
THR A 383
VAL A 377
 None
 0.95A 4udaA-2yfkA:
undetectable		 4udaA-2yfkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 6 PHE A  24
HIS A 165
PRO A 166
LEU A 159
 None
 1.28A 5dzka-2yfkA:
undetectable
5dzko-2yfkA:
undetectable		 5dzka-2yfkA:
19.62
5dzko-2yfkA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 8 GLN A 142
ASN A 110
ALA A 109
SER A 113
 None
 1.00A 5km8A-2yfkA:
undetectable
5km8B-2yfkA:
undetectable		 5km8A-2yfkA:
17.53
5km8B-2yfkA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		5 / 9 GLY A  63
ALA A  81
MET A 371
VAL A 157
LEU A 159
 None
 1.00A 5lw1H-2yfkA:
undetectable		 5lw1H-2yfkA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 7 HIS A 307
TRP A 272
THR A 254
TRP A 310
 None
 1.45A 5yizk-2yfkA:
undetectable
5yizt-2yfkA:
0.0		 5yizk-2yfkA:
13.71
5yizt-2yfkA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 7 HIS A 307
TRP A 272
THR A 254
TRP A 310
 None
 1.45A 5yj1k-2yfkA:
0.0
5yj1t-2yfkA:
0.0		 5yj1k-2yfkA:
14.64
5yj1t-2yfkA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE
(Enterococcus
faecalis) 		4 / 7 THR A 254
TRP A 310
HIS A 307
TRP A 272
 None
 1.40A 5yj1G-2yfkA:
0.0
5yj1Y-2yfkA:
0.0		 5yj1G-2yfkA:
14.64
5yj1Y-2yfkA:
14.64