SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 LEU A 448
TRP A 383
ILE A 412
ARG A 524
TYR A 495
 None
 1.48A 1l7gA-2yfnA:
undetectable		 1l7gA-2yfnA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 4 LEU A 120
GLY A 255
ASP A 526
TYR A 500
 None
 1.33A 1oxrA-2yfnA:
undetectable		 1oxrA-2yfnA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 TYR A 150
LEU A  14
GLY A 113
ILE A   3
LEU A  31
 None
 1.11A 1p91B-2yfnA:
undetectable		 1p91B-2yfnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 9 TYR A  36
LEU A 183
VAL A 295
ILE A 296
TYR A 311
 None
 1.49A 1q6iA-2yfnA:
undetectable		 1q6iA-2yfnA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 TYR A 150
ARG A 270
GLN A  75
 None
 0.93A 1tw4A-2yfnA:
undetectable		 1tw4A-2yfnA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 GLY A 222
ASN A 256
LEU A 448
ASP A 449
PHE A 502
 None
 1.36A 2b9eA-2yfnA:
undetectable		 2b9eA-2yfnA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 HIS A 226
PRO A 230
THR A 223
LEU A 530
ILE A 536
 None
 1.11A 2fj1A-2yfnA:
2.4		 2fj1A-2yfnA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 10 GLU A 260
ASN A  87
GLU A  76
LEU A 148
TYR A 150
 None
 1.40A 2ha6A-2yfnA:
undetectable		 2ha6A-2yfnA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 6 PHE A 251
TYR A 500
ARG A 524
GLY A 255
 None
 1.36A 2i30A-2yfnA:
undetectable		 2i30A-2yfnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 LEU A 137
ILE A 165
ILE A 175
ILE A  88
LEU A 148
 None
 0.95A 2o4nA-2yfnA:
undetectable		 2o4nA-2yfnA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 LEU A 117
TYR A 115
GLY A 113
 None
 0.61A 2ocuA-2yfnA:
undetectable		 2ocuA-2yfnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 6 ILE A 463
ARG A 509
LEU A 506
ASP A 468
 None
 1.00A 2rlfA-2yfnA:
undetectable
2rlfD-2yfnA:
undetectable		 2rlfA-2yfnA:
6.58
2rlfD-2yfnA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 GLN A 445
ASN A 334
ASP A 366
ASP A 478
HIS A 199
 None
 1.17A 2x2iD-2yfnA:
17.1		 2x2iD-2yfnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 ARG A 194
LEU A 304
GLY A 553
ASN A 204
PHE A 257
 None
 1.20A 2zzmA-2yfnA:
undetectable		 2zzmA-2yfnA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 PHE A 556
PHE A 195
LEU A 193
ARG A 207
TYR A 552
 None
 1.50A 3apvA-2yfnA:
undetectable		 3apvA-2yfnA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 PHE A 556
PHE A 195
LEU A 193
ARG A 207
TYR A 552
 None
 1.44A 3apwB-2yfnA:
undetectable		 3apwB-2yfnA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 4 GLU A 302
GLY A 303
THR A 242
GLU A 241
 None
 1.02A 3e9xA-2yfnA:
undetectable		 3e9xA-2yfnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 GLN A 535
ARG A 547
ILE A 360
TYR A 474
LEU A 332
 None
 1.09A 3iizA-2yfnA:
6.7		 3iizA-2yfnA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 ASN A 276
SER A 258
GLU A 277
ILE A  88
ASN A  87
 None
 1.23A 3jb3A-2yfnA:
undetectable		 3jb3A-2yfnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 GLU A 596
GLY A 368
ASP A 540
ASP A 376
GLY A 520
 None
 1.29A 3jzjA-2yfnA:
undetectable		 3jzjA-2yfnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 8 GLY A 303
LEU A 307
LEU A 304
ILE A 233
 None
 0.90A 3nbqB-2yfnA:
undetectable		 3nbqB-2yfnA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_B_ACTB120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 4 MET A 362
LYS A 407
ASP A 361
ASP A 473
 None
 1.41A 3ncqB-2yfnA:
0.0		 3ncqB-2yfnA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 SER A 645
PHE A 195
ILE A 624
GLU A 241
GLY A 553
 None
 1.06A 3nxuA-2yfnA:
undetectable		 3nxuA-2yfnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 GLN A 613
PHE A 581
TYR A 595
 None
 1.01A 3ucjA-2yfnA:
undetectable		 3ucjA-2yfnA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 ASP A 191
GLU A 236
GLY A 238
 None
GOL  A1722 (-3.1A)
None
 0.70A 3w9tA-2yfnA:
undetectable		 3w9tA-2yfnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 5 ASP A 478
SER A 519
GLY A 521
ASP A 366
 None
 1.19A 3w9tB-2yfnA:
undetectable		 3w9tB-2yfnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 5 ASP A 478
SER A 519
GLY A 521
ASP A 366
 None
 1.19A 3w9tC-2yfnA:
undetectable		 3w9tC-2yfnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 6 MET A 529
GLY A 517
TRP A 477
GLU A 415
 None
 1.43A 4bqfA-2yfnA:
undetectable		 4bqfA-2yfnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 7 GLU A 415
ARG A 373
VAL A 459
TRP A 383
 None
 1.43A 4jseA-2yfnA:
undetectable
4jseB-2yfnA:
undetectable		 4jseA-2yfnA:
21.75
4jseB-2yfnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 GLN A 535
ARG A 547
ILE A 360
TYR A 474
LEU A 332
 None
 1.08A 4jxcA-2yfnA:
6.6		 4jxcA-2yfnA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 ARG A 456
ASP A 461
ASP A 468
 None
 0.63A 4kicB-2yfnA:
undetectable		 4kicB-2yfnA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 ARG A 689
GLU A 684
PHE A 717
 None
 0.74A 4kszA-2yfnA:
undetectable		 4kszA-2yfnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 9 GLY A  81
SER A 100
TYR A  30
ASP A 139
THR A  82
 None
 1.43A 4lb0A-2yfnA:
undetectable		 4lb0A-2yfnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 8 SER A 224
TYR A 558
ILE A 536
GLU A 202
 None
 1.01A 4ms4A-2yfnA:
undetectable		 4ms4A-2yfnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 LEU A 448
TRP A 383
ILE A 412
ARG A 524
TYR A 495
 None
 1.49A 4mwvA-2yfnA:
undetectable		 4mwvA-2yfnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 4 ALA A 544
VAL A 570
GLY A 576
THR A 575
 None
 1.05A 4ubeA-2yfnA:
undetectable		 4ubeA-2yfnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 LEU A 673
LEU A 632
ILE A 640
VAL A 657
PHE A 715
 None
 0.91A 4y0sA-2yfnA:
undetectable		 4y0sA-2yfnA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 11 VAL A 466
PHE A 502
PHE A 450
TRP A 477
GLY A 381
 None
 1.40A 4zvmA-2yfnA:
undetectable
4zvmB-2yfnA:
undetectable		 4zvmA-2yfnA:
16.18
4zvmB-2yfnA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 6 ARG A 481
ASP A 485
ARG A 433
ILE A 432
 None
 1.32A 5a06A-2yfnA:
undetectable		 5a06A-2yfnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 ASP A 651
VAL A 646
LEU A 676
 None
 0.61A 5e5jB-2yfnA:
undetectable		 5e5jB-2yfnA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 ARG A 674
HIS A 698
ARG A 672
 None
 0.70A 5iaoC-2yfnA:
undetectable		 5iaoC-2yfnA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 ARG A 674
HIS A 698
ARG A 672
 None
 0.75A 5iaoF-2yfnA:
undetectable		 5iaoF-2yfnA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 5 TYR A 552
GLY A 553
THR A 554
GLY A 188
 None
None
None
GOL  A1722 ( 4.0A)
 0.70A 5jlcA-2yfnA:
undetectable		 5jlcA-2yfnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 7 ARG A 203
GLN A 551
ILE A 550
GLY A 553
 None
 1.01A 5nzyA-2yfnA:
undetectable		 5nzyA-2yfnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 7 THR A  82
LEU A 272
VAL A 292
GLU A 278
 None
None
None
MG  A1726 ( 4.9A)
 0.95A 5tudA-2yfnA:
undetectable		 5tudA-2yfnA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 PHE A 280
PHE A 251
GLY A 274
GLU A 278
LEU A 279
 None
None
None
MG  A1726 ( 4.9A)
None
 1.20A 5ul4A-2yfnA:
3.0		 5ul4A-2yfnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 PHE A 450
ILE A 417
ALA A 431
ALA A 484
GLY A 222
 None
None
None
GOL  A1721 (-4.1A)
None
 1.07A 5veuA-2yfnA:
undetectable		 5veuA-2yfnA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 HIS A 199
ARG A 373
GLY A 368
GLY A 520
GLY A 521
 None
 1.18A 6brdB-2yfnA:
undetectable		 6brdB-2yfnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		5 / 12 VAL A 319
VAL A 123
GLY A 248
VAL A 232
PHE A 217
 None
 1.16A 6brdC-2yfnA:
undetectable		 6brdC-2yfnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		4 / 6 GLY A 255
ASN A 256
SER A 225
ARG A 524
 None
 1.09A 6dwdA-2yfnA:
undetectable
6dwdC-2yfnA:
undetectable		 6dwdA-2yfnA:
21.05
6dwdC-2yfnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK
([Ruminococcus]
gnavus) 		3 / 3 THR A 575
GLU A 596
ASN A 541
 None
 0.91A 6nj9K-2yfnA:
undetectable		 6nj9K-2yfnA:
21.97