SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 8 THR A 555
ASN A 556
ASP A 471
ASP A 549
 None
 1.03A 1bu5B-2yfsA:
undetectable		 1bu5B-2yfsA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 6 VAL A 559
GLY A 560
ALA A 589
LEU A 232
 None
 0.79A 1e7bB-2yfsA:
undetectable		 1e7bB-2yfsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 7 ILE A 249
THR A 597
GLN A 658
MET A 655
 None
 1.26A 1kglA-2yfsA:
undetectable		 1kglA-2yfsA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		5 / 11 THR A 656
SER A 667
SER A 638
VAL A 605
THR A 617
 None
CA  A1712 (-2.3A)
None
None
None
 1.04A 1q23F-2yfsA:
undetectable		 1q23F-2yfsA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		3 / 3 ASN A 305
TRP A 339
GLN A 261
 SUC  A1710 (-3.5A)
SUC  A1709 (-4.2A)
None
 0.82A 1xoqA-2yfsA:
undetectable		 1xoqA-2yfsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 8 ASP A 431
TYR A 535
TYR A 437
HIS A 427
 None
 1.42A 2ha2A-2yfsA:
undetectable		 2ha2A-2yfsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 8 ASP A 431
TYR A 535
TYR A 437
HIS A 427
 None
 1.43A 2ha2B-2yfsA:
undetectable		 2ha2B-2yfsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		5 / 11 ARG A 436
THR A 281
VAL A 428
VAL A 276
ILE A 351
 None
 1.07A 2zbzA-2yfsA:
undetectable		 2zbzA-2yfsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 6 GLY A 584
THR A 541
GLU A 582
GLU A 234
 None
 0.89A 3fpjA-2yfsA:
undetectable		 3fpjA-2yfsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 8 ALA A 246
ILE A 249
ASN A 245
PRO A 637
 None
 1.01A 3fxrA-2yfsA:
undetectable		 3fxrA-2yfsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		3 / 3 ASN A 251
MET A 672
PHE A 319
 None
 1.13A 3g4lD-2yfsA:
undetectable		 3g4lD-2yfsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_A_ACTA511_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 4 ASN A 209
PHE A 210
SER A 211
GLN A 182
 None
 1.08A 3v5vA-2yfsA:
0.0		 3v5vA-2yfsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 5 GLY A 400
TYR A 403
TYR A 405
GLU A 447
 None
 1.36A 4ae1B-2yfsA:
undetectable		 4ae1B-2yfsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		5 / 12 GLN A 291
GLY A 289
ASP A 664
SER A 666
ASN A 317
 None
None
CA  A1712 ( 4.2A)
None
CA  A1712 (-2.9A)
 1.43A 5d0yA-2yfsA:
undetectable		 5d0yA-2yfsA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 5 SER A 590
ALA A 589
HIS A 707
LEU A 704
 None
 1.49A 5dzkb-2yfsA:
undetectable
5dzkp-2yfsA:
undetectable		 5dzkb-2yfsA:
17.51
5dzkp-2yfsA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 5 SER A 590
ALA A 589
HIS A 707
LEU A 704
 None
 1.48A 5dzkc-2yfsA:
undetectable
5dzkq-2yfsA:
undetectable		 5dzkc-2yfsA:
17.51
5dzkq-2yfsA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 8 LEU A 476
LEU A 469
GLN A 219
MET A 518
 None
 1.16A 5hbsA-2yfsA:
undetectable		 5hbsA-2yfsA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 6 LEU A 676
ILE A 620
THR A 597
MET A 655
 None
 1.39A 5ljeA-2yfsA:
undetectable		 5ljeA-2yfsA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		4 / 5 VAL A 585
HIS A 707
LEU A 641
ASP A 236
 None
 1.49A 5vcvA-2yfsA:
undetectable		 5vcvA-2yfsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		5 / 12 LEU A 309
ILE A 294
GLY A 295
ILE A 388
ILE A 328
 None
 0.79A 6emuB-2yfsA:
undetectable		 6emuB-2yfsA:
16.11