SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 0.91A 2eilP-2yfuA:
undetectable
2eilW-2yfuA:
undetectable		 2eilP-2yfuA:
19.85
2eilW-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 0.89A 3ablP-2yfuA:
undetectable
3ablW-2yfuA:
undetectable		 3ablP-2yfuA:
19.85
3ablW-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 0.94A 3asoC-2yfuA:
undetectable
3asoJ-2yfuA:
undetectable		 3asoC-2yfuA:
19.85
3asoJ-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
PHE A  77
PHE A 134
PHE A  27
 None
None
None
GOL  A1143 (-4.6A)
 1.05A 3ko0D-2yfuA:
undetectable
3ko0E-2yfuA:
undetectable		 3ko0D-2yfuA:
24.10
3ko0E-2yfuA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PHE A  27
GLY A  14
PHE A  77
PHE A 134
 GOL  A1143 (-4.6A)
None
None
None
 1.07A 3ko0B-2yfuA:
undetectable
3ko0J-2yfuA:
undetectable		 3ko0B-2yfuA:
24.10
3ko0J-2yfuA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 PHE A  27
GLY A  14
PHE A  77
PHE A 134
 GOL  A1143 (-4.6A)
None
None
None
 1.06A 3ko0K-2yfuA:
undetectable
3ko0S-2yfuA:
undetectable		 3ko0K-2yfuA:
24.10
3ko0S-2yfuA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 SER A 125
ASP A  30
ASP A  36
 None
None
GOL  A1142 (-2.8A)
 0.68A 4uckA-2yfuA:
undetectable		 4uckA-2yfuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A  94
GLY A  74
PHE A  85
PHE A 114
 None
 1.11A 5hieA-2yfuA:
undetectable		 5hieA-2yfuA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.03A 5z84P-2yfuA:
undetectable
5z84W-2yfuA:
undetectable		 5z84P-2yfuA:
19.85
5z84W-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.02A 5z85P-2yfuA:
undetectable
5z85W-2yfuA:
undetectable		 5z85P-2yfuA:
19.85
5z85W-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.03A 5z86C-2yfuA:
undetectable
5z86J-2yfuA:
undetectable		 5z86C-2yfuA:
19.85
5z86J-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.01A 5z86P-2yfuA:
undetectable
5z86W-2yfuA:
undetectable		 5z86P-2yfuA:
19.85
5z86W-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.01A 5zcoP-2yfuA:
undetectable
5zcoW-2yfuA:
undetectable		 5zcoP-2yfuA:
19.85
5zcoW-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.06A 5zcpC-2yfuA:
undetectable
5zcpJ-2yfuA:
undetectable		 5zcpC-2yfuA:
19.85
5zcpJ-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yfu CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.06A 5zcpP-2yfuA:
undetectable
5zcpW-2yfuA:
undetectable		 5zcpP-2yfuA:
19.85
5zcpW-2yfuA:
17.42