SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		10 / 12 ALA A 145
TYR A 147
TYR A 173
ASP A 175
GLN A 177
GLU A 214
ASP A 216
GLU A 219
ARG A 251
ASP A 377
 None
 0.26A 1dy4A-2yg1A:
61.7		 1dy4A-2yg1A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 5 HIS A 230
TRP A 375
ALA A 380
TRP A 384
 None
 0.35A 1dy4A-2yg1A:
61.7		 1dy4A-2yg1A:
56.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 5 THR A   5
LEU A  73
GLY A  75
TYR A 169
 None
PCA  A   1 ( 4.3A)
None
None
 1.25A 1gtiF-2yg1A:
undetectable		 1gtiF-2yg1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 6 LEU A 385
LEU A 274
GLY A 275
ILE A 222
 None
 0.85A 1mt1G-2yg1A:
undetectable
1mt1J-2yg1A:
undetectable		 1mt1G-2yg1A:
12.19
1mt1J-2yg1A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 7 ILE A 222
LEU A 385
LEU A 274
GLY A 275
 None
 0.83A 1mt1H-2yg1A:
undetectable
1mt1K-2yg1A:
undetectable		 1mt1H-2yg1A:
11.40
1mt1K-2yg1A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 6 SER A 167
THR A 171
LEU A  34
ASP A  35
 None
PCA  A   1 ( 4.9A)
None
None
 1.28A 1mxdA-2yg1A:
undetectable		 1mxdA-2yg1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 8 LEU A 385
LEU A 274
GLY A 275
ILE A 222
 None
 0.83A 1n13A-2yg1A:
undetectable
1n13F-2yg1A:
undetectable		 1n13A-2yg1A:
12.19
1n13F-2yg1A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 6 PHE A 426
VAL A 424
LEU A 138
PHE A 131
 None
 0.90A 1wrlB-2yg1A:
undetectable		 1wrlB-2yg1A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 GLY A 248
GLU A 379
ASP A 249
 None
 0.59A 2b25B-2yg1A:
undetectable		 2b25B-2yg1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 LEU A  34
TYR A  82
GLY A  80
 None
 0.62A 2ocuA-2yg1A:
undetectable		 2ocuA-2yg1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 GLY A 170
ARG A  39
TYR A 110
 None
 0.78A 2opxA-2yg1A:
undetectable		 2opxA-2yg1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 8 ILE A 222
LEU A 385
LEU A 274
GLY A 275
 None
 0.85A 2qqcH-2yg1A:
undetectable
2qqcK-2yg1A:
undetectable		 2qqcH-2yg1A:
13.46
2qqcK-2yg1A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 6 SER A 373
ASP A 216
TYR A 147
PRO A 179
 None
 1.50A 3jqaB-2yg1A:
undetectable		 3jqaB-2yg1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 6 SER A 373
ASP A 216
TYR A 147
PRO A 179
 None
 1.50A 3jqaD-2yg1A:
undetectable		 3jqaD-2yg1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 8 ASP A 216
GLY A 260
GLU A 219
ARG A 251
 None
 1.03A 3s3nA-2yg1A:
undetectable		 3s3nA-2yg1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		5 / 9 ASP A 386
SER A 387
THR A 407
GLY A 410
ASP A 376
 None
 1.45A 3sfuA-2yg1A:
undetectable		 3sfuA-2yg1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 GLN A   6
THR A  44
THR A  43
 None
 0.76A 4fu9A-2yg1A:
undetectable		 4fu9A-2yg1A:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		9 / 9 ASN A 143
ALA A 145
TYR A 147
TYR A 173
ASP A 175
GLU A 214
ASP A 216
GLU A 219
TRP A 375
 None
 0.44A 4ipmA-2yg1A:
63.5		 4ipmA-2yg1A:
59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 SER A 224
ALA A 226
VAL A 227
 None
 0.66A 4o2bC-2yg1A:
undetectable		 4o2bC-2yg1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 5 TYR A 173
SER A 373
ASP A 216
ASP A 262
 None
 1.03A 4qtuB-2yg1A:
undetectable		 4qtuB-2yg1A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 SER A 224
ALA A 226
VAL A 227
 None
 0.50A 4x1iA-2yg1A:
undetectable		 4x1iA-2yg1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 4 ASN A 163
SER A 167
ALA A 165
VAL A   3
 PCA  A   1 (-3.6A)
None
PCA  A   1 ( 3.6A)
None
 1.26A 4x1kC-2yg1A:
undetectable		 4x1kC-2yg1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 SER A 224
ALA A 226
VAL A 227
 None
 0.51A 4x20C-2yg1A:
undetectable		 4x20C-2yg1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 5 ASP A 335
VAL A 231
ASP A 257
GLY A 260
 None
 1.02A 4xp6A-2yg1A:
undetectable		 4xp6A-2yg1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		3 / 3 SER A 224
ALA A 226
VAL A 227
 None
 0.55A 5eypA-2yg1A:
undetectable		 5eypA-2yg1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		4 / 8 GLN A 244
GLY A 209
ASP A 175
ASP A 181
 None
 1.00A 5vlmH-2yg1A:
undetectable		 5vlmH-2yg1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		5 / 12 VAL A 149
GLU A 214
LEU A  91
LEU A  14
LEU A  93
 None
 0.96A 6ew0B-2yg1A:
undetectable		 6ew0B-2yg1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		5 / 12 VAL A 149
GLU A 214
LEU A  91
LEU A  14
LEU A  93
 None
 0.96A 6ew0D-2yg1A:
undetectable		 6ew0D-2yg1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		5 / 12 VAL A 149
GLU A 214
LEU A  91
LEU A  14
LEU A  93
 None
 0.96A 6ew0H-2yg1A:
undetectable		 6ew0H-2yg1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Heterobasidion
annosum) 		5 / 12 VAL A 149
GLU A 214
LEU A  91
LEU A  14
LEU A  93
 None
 0.96A 6ew0I-2yg1A:
undetectable		 6ew0I-2yg1A:
10.34