SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 10 LEU A 174
MET A 285
LEU A 188
GLN A 185
HIS A 286
 None
 1.47A 1aqbA-2yg6A:
undetectable		 1aqbA-2yg6A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 11 SER A 398
LEU A 199
SER A 192
LEU A 188
ILE A 169
 None
 1.34A 1ee2A-2yg6A:
undetectable		 1ee2A-2yg6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 11 SER A 398
LEU A 199
SER A 192
LEU A 188
ILE A 169
 None
 1.37A 1ee2B-2yg6A:
undetectable		 1ee2B-2yg6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 THR A  66
PHE A 204
GLU A 428
GLY A 194
 None
 0.75A 1icuA-2yg6A:
undetectable
1icuB-2yg6A:
undetectable		 1icuA-2yg6A:
19.38
1icuB-2yg6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 PHE A 204
GLU A 428
GLY A 194
THR A  66
 None
 0.72A 1icuA-2yg6A:
undetectable
1icuB-2yg6A:
undetectable		 1icuA-2yg6A:
19.38
1icuB-2yg6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 THR A  66
PHE A 204
GLU A 428
GLY A 194
 None
 0.81A 1icuC-2yg6A:
undetectable
1icuD-2yg6A:
undetectable		 1icuC-2yg6A:
19.38
1icuD-2yg6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 ASP A 144
LEU A 188
LEU A 184
 None
 0.75A 1ikeA-2yg6A:
undetectable		 1ikeA-2yg6A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 THR A  66
PHE A 204
GLU A 428
GLY A 194
 None
 0.74A 1kqbA-2yg6A:
undetectable
1kqbB-2yg6A:
undetectable		 1kqbA-2yg6A:
19.77
1kqbB-2yg6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 THR A  66
PHE A 204
GLU A 428
GLY A 194
 None
 0.73A 1kqbC-2yg6A:
undetectable
1kqbD-2yg6A:
undetectable		 1kqbC-2yg6A:
19.77
1kqbD-2yg6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 PHE A 204
GLU A 428
GLY A 194
THR A  66
 None
 0.81A 1kqbC-2yg6A:
undetectable
1kqbD-2yg6A:
undetectable		 1kqbC-2yg6A:
19.77
1kqbD-2yg6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 ASP A 144
LEU A 188
LEU A 184
 None
 0.68A 1np1B-2yg6A:
undetectable		 1np1B-2yg6A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 4 ALA A 126
VAL A 187
ALA A 190
HIS A 198
 None
 1.12A 1q23A-2yg6A:
undetectable		 1q23A-2yg6A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 10 LEU A 143
ALA A 191
VAL A 146
GLN A 155
GLN A 128
 None
 1.22A 1rlbE-2yg6A:
undetectable		 1rlbE-2yg6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 7 GLY A 435
GLN A  65
ILE A  15
VAL A 437
 None
FAD  A 600 ( 4.5A)
None
None
 1.08A 1rxcF-2yg6A:
undetectable		 1rxcF-2yg6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 GLU A 114
ARG A 117
MET A 115
ASP A 123
ILE A 165
 None
 1.40A 1s14B-2yg6A:
undetectable		 1s14B-2yg6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 PHE A 168
TYR A 100
TYR A  90
 None
 1.00A 1x70B-2yg6A:
undetectable		 1x70B-2yg6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 8 GLY A  14
THR A  22
ILE A  15
SER A 218
 FAD  A 600 (-3.6A)
None
None
None
 0.94A 2a8tB-2yg6A:
undetectable		 2a8tB-2yg6A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 11 GLN A 441
LEU A  68
ALA A  19
LEU A  18
SER A 218
 None
 1.36A 2c12F-2yg6A:
undetectable		 2c12F-2yg6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 11 ALA A 249
VAL A  11
ILE A 272
ALA A   9
ILE A  34
 None
FAD  A 600 (-4.7A)
None
None
None
 1.01A 2idwA-2yg6A:
undetectable		 2idwA-2yg6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 GLY A  14
ALA A  13
VAL A 229
VAL A  31
VAL A  33
 FAD  A 600 (-3.6A)
None
None
None
None
 0.93A 2ieoB-2yg6A:
undetectable		 2ieoB-2yg6A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 ARG A 392
GLY A 393
SER A 423
 None
None
FAD  A 600 (-2.7A)
 0.58A 2xctB-2yg6A:
undetectable		 2xctB-2yg6A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 ILE A 169
LEU A 199
PHE A 168
MET A 122
 None
 0.91A 3adsA-2yg6A:
undetectable		 3adsA-2yg6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 GLY A 435
ILE A  69
LEU A  72
VAL A 217
ILE A  15
 None
 1.38A 3adsB-2yg6A:
undetectable		 3adsB-2yg6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 7 ILE A 169
LEU A 199
PHE A 168
MET A 122
 None
 0.86A 3adxA-2yg6A:
undetectable		 3adxA-2yg6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 5 ASN A 164
PHE A 168
ALA A 318
GLY A 317
 None
 1.15A 3bcrA-2yg6A:
undetectable		 3bcrA-2yg6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 VAL A  11
ALA A  20
ALA A  21
ALA A 444
VAL A 247
 FAD  A 600 (-4.7A)
None
None
None
None
 0.93A 3fc6C-2yg6A:
undetectable		 3fc6C-2yg6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 ASN A 164
MET A 173
PHE A 168
 None
 1.04A 3g4lD-2yg6A:
undetectable		 3g4lD-2yg6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		6 / 12 ALA A 374
LEU A 363
LEU A 338
ALA A 299
VAL A  89
ILE A  91
 None
 1.28A 3h0aA-2yg6A:
undetectable		 3h0aA-2yg6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 GLY A 435
GLN A  65
ILE A  15
VAL A 437
 None
FAD  A 600 ( 4.5A)
None
None
 1.13A 3kvvA-2yg6A:
undetectable		 3kvvA-2yg6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 GLY A 435
GLN A  65
ILE A  15
VAL A 437
 None
FAD  A 600 ( 4.5A)
None
None
 1.14A 3kvvB-2yg6A:
undetectable		 3kvvB-2yg6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 GLY A 435
GLN A  65
ILE A  15
VAL A 437
 None
FAD  A 600 ( 4.5A)
None
None
 1.14A 3kvvC-2yg6A:
undetectable		 3kvvC-2yg6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 GLY A 435
GLN A  65
ILE A  15
VAL A 437
 None
FAD  A 600 ( 4.5A)
None
None
 1.12A 3kvvF-2yg6A:
undetectable		 3kvvF-2yg6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 9 ALA A 249
ASP A 250
GLY A  12
ILE A  10
ILE A 253
 None
None
FAD  A 600 (-3.3A)
None
None
 1.08A 3nu4A-2yg6A:
undetectable		 3nu4A-2yg6A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 9 ALA A 249
ASP A 250
GLY A  12
ILE A  10
ILE A 253
 None
None
FAD  A 600 (-3.3A)
None
None
 1.08A 3nuoA-2yg6A:
undetectable		 3nuoA-2yg6A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 7 LEU A  68
VAL A  61
VAL A 217
LEU A 206
 None
 0.83A 3rgfA-2yg6A:
undetectable		 3rgfA-2yg6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 GLN A 215
ARG A 236
GLY A  14
ALA A  13
ALA A  36
 None
None
FAD  A 600 (-3.6A)
None
FAD  A 600 (-3.5A)
 1.06A 3sudA-2yg6A:
undetectable		 3sudA-2yg6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 ARG A  37
ASP A 424
GLN A 431
 FAD  A 600 (-3.8A)
None
None
 0.88A 4azsA-2yg6A:
undetectable		 4azsA-2yg6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 LEU A 174
SER A 290
GLN A 185
GLN A 289
ILE A 425
 None
 1.40A 4b3aA-2yg6A:
undetectable		 4b3aA-2yg6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 6 GLY A 435
GLN A  65
ILE A  15
VAL A 437
 None
FAD  A 600 ( 4.5A)
None
None
 1.10A 4e1vF-2yg6A:
undetectable		 4e1vF-2yg6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 ASP A 410
GLY A 408
ASP A 144
HIS A 405
GLY A 402
 None
 0.93A 4lxzA-2yg6A:
undetectable		 4lxzA-2yg6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 ASP A 410
GLY A 408
ASP A 144
HIS A 405
GLY A 402
 None
 0.96A 4lxzC-2yg6A:
undetectable		 4lxzC-2yg6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 4 THR A 314
GLY A 102
ASP A 103
SER A  88
 None
 1.39A 4rfqA-2yg6A:
undetectable		 4rfqA-2yg6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 SER A  93
TYR A  90
ASP A 158
 None
 0.83A 4rp8C-2yg6A:
undetectable		 4rp8C-2yg6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 SER A 343
SER A 182
GLU A 324
LEU A 199
GLY A 166
 None
 1.14A 4zjlA-2yg6A:
undetectable		 4zjlA-2yg6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 SER A 411
GLY A 408
ASP A 144
PHE A 399
LEU A 188
 None
 1.25A 5eeiA-2yg6A:
undetectable		 5eeiA-2yg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 SER A 411
GLY A 408
ASP A 144
PHE A 399
LEU A 188
 None
 1.24A 5eeiB-2yg6A:
undetectable		 5eeiB-2yg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 GLY A 440
GLN A 289
TYR A 269
GLY A 435
GLN A 441
 None
 1.23A 5hg0A-2yg6A:
undetectable		 5hg0A-2yg6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 ILE A 272
ALA A  36
SER A 421
ILE A 261
PHE A 420
 None
FAD  A 600 (-3.5A)
None
None
None
 1.36A 5iwuA-2yg6A:
undetectable		 5iwuA-2yg6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 THR A 391
PRO A 265
ASP A 424
 FAD  A 600 ( 4.9A)
FAD  A 600 ( 4.7A)
None
 0.66A 5l8dB-2yg6A:
undetectable		 5l8dB-2yg6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		3 / 3 THR A 391
PRO A 265
ASP A 424
 FAD  A 600 ( 4.9A)
FAD  A 600 ( 4.7A)
None
 0.66A 5mwuB-2yg6A:
undetectable		 5mwuB-2yg6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 SER A  70
LEU A  72
GLN A  59
TRP A  60
VAL A  61
 None
 1.29A 5ubbA-2yg6A:
undetectable		 5ubbA-2yg6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 8 THR A 314
TYR A 100
PHE A 105
TYR A 326
 None
 1.27A 5v4vA-2yg6A:
undetectable		 5v4vA-2yg6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 8 THR A 314
TYR A 100
PHE A 105
TYR A 326
 None
 1.29A 5v4vB-2yg6A:
undetectable		 5v4vB-2yg6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		6 / 12 GLY A  17
GLY A 440
VAL A  33
ILE A  15
LEU A  18
LEU A 225
 None
 1.29A 5wy0A-2yg6A:
undetectable		 5wy0A-2yg6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		5 / 12 ALA A 444
VAL A  33
GLY A  14
ALA A  13
LEU A 225
 None
None
FAD  A 600 (-3.6A)
None
None
 1.03A 5xxiA-2yg6A:
undetectable		 5xxiA-2yg6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2yg6 PUTRESCINE OXIDASE
(Rhodococcus
erythropolis) 		4 / 7 ARG A 442
ARG A 412
THR A 413
PRO A 414
 None
None
None
GOL  A1452 (-3.7A)
 1.34A 6a4iB-2yg6A:
undetectable		 6a4iB-2yg6A:
20.44