SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 6 LEU A  86
VAL A  66
VAL A 116
GLN A 120
 None
 1.01A 1e7aB-2yg8A:
undetectable		 1e7aB-2yg8A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 LEU A  86
LEU A 111
GLY A  71
ARG A  67
ALA A  79
 None
 0.98A 2br4E-2yg8A:
undetectable		 2br4E-2yg8A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 6 LEU A  36
ASP A 171
LEU A  23
TRP A 200
 None
 1.26A 3bj8C-2yg8A:
undetectable
3bj8D-2yg8A:
undetectable		 3bj8C-2yg8A:
20.00
3bj8D-2yg8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 LEU A  65
LEU A  98
GLY A  71
ALA A  70
LEU A 111
 None
 1.07A 3n8xB-2yg8A:
undetectable		 3n8xB-2yg8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 10 THR A 197
GLY A 183
VAL A  41
ASP A  39
VAL A  45
 None
None
GOL  A1228 (-4.2A)
None
None
 1.26A 4c9nB-2yg8A:
undetectable		 4c9nB-2yg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 10 THR A 197
GLY A 183
VAL A  41
ASP A  39
VAL A  45
 None
None
GOL  A1228 (-4.2A)
None
None
 1.26A 4c9pB-2yg8A:
undetectable		 4c9pB-2yg8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 GLY A 103
THR A 118
LEU A 111
GLY A 108
VAL A 109
 None
 0.71A 4o33A-2yg8A:
undetectable		 4o33A-2yg8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 6 LEU A 111
VAL A 119
LEU A  98
VAL A  66
 None
 0.97A 5x7zA-2yg8A:
undetectable		 5x7zA-2yg8A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 VAL A  69
LEU A 111
VAL A 116
PHE A 133
VAL A  93
 None
 1.17A 6a94B-2yg8A:
2.2		 6a94B-2yg8A:
22.94