SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ygk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 4 LEU A 162
SER A 118
LEU A 178
LEU A 111
 None
 1.06A 1yajA-2ygkA:
undetectable		 1yajA-2ygkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2ygk NURA
(Sulfolobus
solfataricus) 		5 / 12 ILE A  57
ILE A 108
SER A 109
ALA A  73
ASP A  92
 None
 1.15A 2ejtA-2ygkA:
undetectable		 2ejtA-2ygkA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2ygk NURA
(Sulfolobus
solfataricus) 		5 / 12 ILE A  57
ILE A 108
SER A 109
ALA A  73
ASP A  92
 None
 1.19A 3axtA-2ygkA:
undetectable		 3axtA-2ygkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 6 LEU A 177
MET A 174
ILE A  68
ILE A  70
 None
 0.90A 3gcsA-2ygkA:
undetectable		 3gcsA-2ygkA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ygk NURA
(Sulfolobus
solfataricus) 		3 / 3 LEU A 177
LEU A 180
ARG A 158
 None
 0.75A 3hcnB-2ygkA:
undetectable		 3hcnB-2ygkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 6 ASP A  58
GLY A 134
LEU A 302
GLU A 116
 MN  A1336 (-2.8A)
None
None
MN  A1336 ( 4.4A)
 1.09A 3w9tB-2ygkA:
undetectable		 3w9tB-2ygkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 6 CYH A  52
THR A  51
ASN A  83
ILE A  80
 None
 1.37A 3w9tB-2ygkA:
undetectable		 3w9tB-2ygkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 6 ASP A  58
GLY A 134
LEU A 302
GLU A 116
 MN  A1336 (-2.8A)
None
None
MN  A1336 ( 4.4A)
 1.09A 3w9tE-2ygkA:
undetectable		 3w9tE-2ygkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 6 ASP A  58
GLY A 134
LEU A 302
GLU A 116
 MN  A1336 (-2.8A)
None
None
MN  A1336 ( 4.4A)
 1.09A 3w9tF-2ygkA:
undetectable		 3w9tF-2ygkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2ygk NURA
(Sulfolobus
solfataricus) 		3 / 3 VAL A  55
GLY A  81
LYS A  53
 None
 0.74A 4k50A-2ygkA:
undetectable		 4k50A-2ygkA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2ygk NURA
(Sulfolobus
solfataricus) 		3 / 3 VAL A  55
GLY A  81
LYS A  53
 None
 0.73A 4k50E-2ygkA:
undetectable		 4k50E-2ygkA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 TYR A 256
ASN A 236
ILE A 233
ARG A 271
 None
 1.40A 4o0oA-2ygkA:
undetectable		 4o0oA-2ygkA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 ILE A 320
VAL A  71
ILE A  68
VAL A 323
 None
 0.68A 4xdtA-2ygkA:
1.6		 4xdtA-2ygkA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 7 ILE A 165
LEU A 162
ARG A 158
LEU A 185
 None
 1.00A 5b1bA-2ygkA:
undetectable
5b1bJ-2ygkA:
undetectable		 5b1bA-2ygkA:
19.31
5b1bJ-2ygkA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 6 ILE A 233
PHE A 259
PHE A 210
THR A 224
 None
 1.35A 5g08A-2ygkA:
undetectable		 5g08A-2ygkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8A-2ygkA:
undetectable		 5hm8A-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8B-2ygkA:
undetectable		 5hm8B-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8C-2ygkA:
undetectable		 5hm8C-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8D-2ygkA:
undetectable		 5hm8D-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8E-2ygkA:
undetectable		 5hm8E-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8F-2ygkA:
undetectable		 5hm8F-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.03A 5hm8G-2ygkA:
undetectable		 5hm8G-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.14A 5hm8H-2ygkA:
undetectable		 5hm8H-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 7 LEU A 131
VAL A  79
GLU A  77
ILE A 295
 None
 1.19A 5jh7C-2ygkA:
undetectable		 5jh7C-2ygkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 LEU A 110
ALA A 114
LEU A 117
LEU A 162
 None
 0.80A 5vkqA-2ygkA:
undetectable
5vkqD-2ygkA:
undetectable		 5vkqA-2ygkA:
11.95
5vkqD-2ygkA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 LEU A 162
LEU A 110
ALA A 114
LEU A 117
 None
 0.80A 5vkqA-2ygkA:
undetectable
5vkqB-2ygkA:
undetectable		 5vkqA-2ygkA:
11.95
5vkqB-2ygkA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 LEU A 162
LEU A 110
ALA A 114
LEU A 117
 None
 0.79A 5vkqB-2ygkA:
undetectable
5vkqC-2ygkA:
undetectable		 5vkqB-2ygkA:
11.95
5vkqC-2ygkA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ygk NURA
(Sulfolobus
solfataricus) 		4 / 5 LEU A 162
LEU A 110
ALA A 114
LEU A 117
 None
 0.83A 5vkqC-2ygkA:
undetectable
5vkqD-2ygkA:
undetectable		 5vkqC-2ygkA:
11.95
5vkqD-2ygkA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2ygk NURA
(Sulfolobus
solfataricus) 		5 / 12 MET A 112
ALA A 114
SER A 118
LEU A 119
ILE A  57
 None
 1.42A 5vlmA-2ygkA:
undetectable		 5vlmA-2ygkA:
20.52