SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ygl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		5 / 11 VAL A 196
VAL A 174
GLU A 143
LEU A 227
ILE A 205
 None
 1.36A 1t6zB-2yglA:
undetectable		 1t6zB-2yglA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A 121
GLY A 119
ASN A  97
ASP A 149
THR A 144
 None
 1.21A 2vdvF-2yglA:
undetectable		 2vdvF-2yglA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 126
ALA A 124
VAL A 123
 None
 0.68A 4o2bC-2yglA:
undetectable		 4o2bC-2yglA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 248
GLY A 247
PHE A 324
ALA A 411
TYR A 250
 None
 1.04A 4rtmA-2yglA:
undetectable		 4rtmA-2yglA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 126
ALA A 124
VAL A 123
 None
 0.58A 4x20C-2yglA:
undetectable		 4x20C-2yglA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 124
THR A 189
PHE A 185
ILE A 165
SER A 177
 None
 1.42A 5hgcA-2yglA:
undetectable		 5hgcA-2yglA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		5 / 10 VAL A 321
THR A 322
ILE A 380
ARG A 323
PHE A 409
 None
 1.09A 5mxbA-2yglA:
undetectable		 5mxbA-2yglA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		5 / 11 PHE A 324
SER A 326
ALA A 407
THR A 304
ALA A 306
 None
 1.38A 6efnA-2yglA:
undetectable		 6efnA-2yglA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 377
ILE A 236
ARG A 323
ASN A 242
 None
 1.16A 6hisA-2yglA:
undetectable
6hisB-2yglA:
undetectable		 6hisA-2yglA:
11.63
6hisB-2yglA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 377
ILE A 236
ARG A 323
ASN A 242
 None
 1.16A 6hisB-2yglA:
undetectable
6hisC-2yglA:
undetectable		 6hisB-2yglA:
11.63
6hisC-2yglA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 377
ILE A 236
ARG A 323
ASN A 242
 None
 1.16A 6hisC-2yglA:
undetectable
6hisD-2yglA:
undetectable		 6hisC-2yglA:
11.63
6hisD-2yglA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 377
ILE A 236
ARG A 323
ASN A 242
 None
 1.15A 6hisD-2yglA:
undetectable
6hisE-2yglA:
undetectable		 6hisD-2yglA:
11.63
6hisE-2yglA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		4 / 8 ASN A 242
ASP A 377
ILE A 236
ARG A 323
 None
 1.16A 6hisA-2yglA:
undetectable
6hisE-2yglA:
undetectable		 6hisA-2yglA:
11.63
6hisE-2yglA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 301
TYR A 250
ASN A 242
GLY A 244
 None
 0.97A 6n7fA-2yglA:
undetectable		 6n7fA-2yglA:
12.68