SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ygn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		3 / 3 TYR A 101
VAL A 121
THR A 126
 None
ACT  A1181 ( 4.4A)
ACT  A1181 (-4.8A)
 0.17A 2ygnA-2ygnA:
29.7		 2ygnA-2ygnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  36
ILE A  40
LEU A  48
ILE A  55
MET A  63
ARG A  76
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
 PCF  A1179 ( 4.0A)
None
PCF  A1179 (-4.1A)
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.1A)
MLY  A  72 (-4.5A)
PCF  A1179 (-4.0A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-4.4A)
PCF  A1179 ( 4.7A)
 0.00A 2ygnA-2ygnA:
29.7		 2ygnA-2ygnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 5 ILE A  49
PHE A  66
PRO A  78
VAL A 156
PHE A 173
 PCF  A1179 (-4.8A)
PCF  A1179 (-3.8A)
PCF  A1179 (-4.3A)
None
PCF  A1179 (-3.8A)
 0.00A 2ygnA-2ygnA:
29.7		 2ygnA-2ygnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		7 / 12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
 PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.7A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
 1.30A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
 PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.5A)
PCF  A1179 ( 4.7A)
PCF  A1179 ( 4.1A)
PCF  A1179 (-3.8A)
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-4.4A)
PCF  A1179 ( 4.7A)
PCF  A1179 (-3.8A)
 0.12A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 6 LEU A  48
ILE A  49
MET A  77
PRO A  78
VAL A 156
 PCF  A1179 (-4.1A)
PCF  A1179 (-4.8A)
PCF  A1179 (-4.0A)
PCF  A1179 (-4.3A)
None
 0.25A 2ygoA-2ygnA:
28.2		 2ygoA-2ygnA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  38
ILE A  40
LEU A  48
ILE A  57
MET A  87
TRP A  91
PHE A 138
PHE A 150
VAL A 152
VAL A 154
PRO A 168
PHE A 173
 PCF  A1179 ( 4.0A)
None
PCF  A1179 (-4.1A)
PCF  A1179 ( 4.7A)
PCF  A1179 (-3.6A)
None
None
None
PCF  A1179 (-4.4A)
PCF  A1179 ( 4.7A)
MLY  A 166 ( 3.9A)
PCF  A1179 (-3.8A)
 0.16A 2ygpA-2ygnA:
28.2		 2ygpA-2ygnA:
82.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A  38
ILE A  55
LEU A  48
ILE A  57
PRO A 168
PHE A 173
 PCF  A1179 ( 4.0A)
PCF  A1179 ( 4.5A)
PCF  A1179 (-4.1A)
PCF  A1179 ( 4.7A)
MLY  A 166 ( 3.9A)
PCF  A1179 (-3.8A)
 1.35A 2ygpA-2ygnA:
28.2		 2ygpA-2ygnA:
82.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		7 / 9 ILE A  49
ILE A  55
PHE A  66
PRO A  78
ILE A  80
PHE A  89
VAL A 156
 PCF  A1179 (-4.8A)
PCF  A1179 ( 4.5A)
PCF  A1179 (-3.8A)
PCF  A1179 (-4.3A)
None
PCF  A1179 ( 3.8A)
None
 0.26A 2ygpA-2ygnA:
28.2		 2ygpA-2ygnA:
82.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 9 ILE A  49
ILE A  55
PRO A  78
ILE A  80
PHE A  89
VAL A 127
 PCF  A1179 (-4.8A)
PCF  A1179 ( 4.5A)
PCF  A1179 (-4.3A)
None
PCF  A1179 ( 3.8A)
None
 1.39A 2ygpA-2ygnA:
28.2		 2ygpA-2ygnA:
82.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 9 ILE A  55
PHE A  66
ARG A  76
ILE A  80
PHE A  89
 PCF  A1179 ( 4.5A)
PCF  A1179 (-3.8A)
MLY  A  72 (-4.5A)
None
PCF  A1179 ( 3.8A)
 1.39A 2ygpA-2ygnA:
28.2		 2ygpA-2ygnA:
82.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		11 / 12 LEU A  38
ILE A  40
ILE A  57
PRO A  78
ILE A  80
PRO A  81
MET A  87
PHE A  89
PHE A 103
PHE A 138
VAL A 154
 PCF  A1179 ( 4.0A)
None
PCF  A1179 ( 4.7A)
PCF  A1179 (-4.3A)
None
None
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
None
None
PCF  A1179 ( 4.7A)
 0.42A 2ygqA-2ygnA:
26.1		 2ygqA-2ygnA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		9 / 12 LEU A  38
ILE A  40
LEU A  48
ILE A  57
MET A  87
PHE A  89
PHE A 103
PHE A 138
VAL A 154
 PCF  A1179 ( 4.0A)
None
PCF  A1179 (-4.1A)
PCF  A1179 ( 4.7A)
PCF  A1179 (-3.6A)
PCF  A1179 ( 3.8A)
None
None
PCF  A1179 ( 4.7A)
 0.66A 2ygqA-2ygnA:
26.1		 2ygqA-2ygnA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A  38
ILE A  40
PRO A  81
PHE A  89
PHE A 103
VAL A 154
 PCF  A1179 ( 4.0A)
None
None
PCF  A1179 ( 3.8A)
None
PCF  A1179 ( 4.7A)
 1.29A 2ygqA-2ygnA:
26.1		 2ygqA-2ygnA:
48.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 7 ASN A 170
ILE A 172
PHE A 174
GLN A  74
 None
 1.03A 3tvxB-2ygnA:
undetectable		 3tvxB-2ygnA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1179 (-4.1A)
None
PCF  A1179 ( 4.7A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-3.6A)
 1.06A 4y0pA-2ygnA:
undetectable		 4y0pA-2ygnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1179 (-4.1A)
None
PCF  A1179 ( 4.7A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-3.6A)
 1.11A 4y0qA-2ygnA:
undetectable		 4y0qA-2ygnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 8 VAL A 127
ALA A  93
GLY A  95
GLY A  34
 None
 0.89A 5e26C-2ygnA:
undetectable
5e26D-2ygnA:
undetectable		 5e26C-2ygnA:
20.29
5e26D-2ygnA:
20.29