SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ygo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		3 / 3 TYR A 101
VAL A 121
THR A 126
 None
 0.10A 2ygnA-2ygoA:
28.2		 2ygnA-2ygoA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		8 / 12 ILE A  40
ILE A  55
ARG A  76
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
 None
PCF  A1213 (-4.0A)
PCF  A1213 (-3.6A)
PCF  A1213 (-3.5A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
 1.08A 2ygnA-2ygoA:
28.2		 2ygnA-2ygoA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		11 / 12 LEU A  36
ILE A  40
LEU A  48
ILE A  55
MET A  63
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
 PCF  A1213 ( 4.2A)
None
PCF  A1213 (-4.3A)
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.2A)
PCF  A1213 (-3.5A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
PCF  A1213 ( 4.7A)
 0.13A 2ygnA-2ygoA:
28.2		 2ygnA-2ygoA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 5 ILE A  49
PHE A  66
PRO A  78
VAL A 156
PHE A 173
 PCF  A1213 (-4.6A)
PCF  A1213 ( 3.6A)
PCF  A1213 (-4.0A)
None
PCF  A1213 (-3.8A)
 0.26A 2ygnA-2ygoA:
28.2		 2ygnA-2ygoA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		7 / 12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
 PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.8A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
 1.32A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
 PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.0A)
PCF  A1213 ( 4.8A)
PCF  A1213 ( 4.2A)
PCF  A1213 ( 3.6A)
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 4.7A)
PCF  A1213 ( 4.7A)
PCF  A1213 (-3.8A)
 0.00A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 6 LEU A  48
ILE A  49
ARG A  76
MET A  77
PRO A  78
VAL A 156
 PCF  A1213 (-4.3A)
PCF  A1213 (-4.6A)
PCF  A1213 (-3.6A)
PCF  A1213 (-3.5A)
PCF  A1213 (-4.0A)
None
 0.00A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 6 LEU A  48
ILE A  49
PRO A  78
VAL A 127
 PCF  A1213 (-4.3A)
PCF  A1213 (-4.6A)
PCF  A1213 (-4.0A)
None
 1.12A 2ygoA-2ygoA:
30.4		 2ygoA-2ygoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  38
ILE A  40
LEU A  48
ILE A  57
MET A  87
TRP A  91
PHE A 138
PHE A 150
VAL A 152
VAL A 154
PRO A 168
PHE A 173
 PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.3A)
PCF  A1213 ( 4.8A)
PCF  A1213 ( 3.8A)
None
None
None
PCF  A1213 ( 4.7A)
PCF  A1213 ( 4.7A)
MLY  A 166 ( 4.0A)
PCF  A1213 (-3.8A)
 0.13A 2ygpA-2ygoA:
29.0		 2ygpA-2ygoA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A  38
ILE A  55
LEU A  48
ILE A  57
PRO A 168
PHE A 173
 PCF  A1213 ( 3.9A)
PCF  A1213 (-4.0A)
PCF  A1213 (-4.3A)
PCF  A1213 ( 4.8A)
MLY  A 166 ( 4.0A)
PCF  A1213 (-3.8A)
 1.36A 2ygpA-2ygoA:
29.0		 2ygpA-2ygoA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		8 / 9 ILE A  49
ILE A  55
PHE A  66
ARG A  76
PRO A  78
ILE A  80
PHE A  89
VAL A 156
 PCF  A1213 (-4.6A)
PCF  A1213 (-4.0A)
PCF  A1213 ( 3.6A)
PCF  A1213 (-3.6A)
PCF  A1213 (-4.0A)
None
PCF  A1213 (-4.1A)
None
 0.30A 2ygpA-2ygoA:
29.0		 2ygpA-2ygoA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 9 ILE A  49
ILE A  55
PRO A  78
ILE A  80
PHE A  89
VAL A 127
 PCF  A1213 (-4.6A)
PCF  A1213 (-4.0A)
PCF  A1213 (-4.0A)
None
PCF  A1213 (-4.1A)
None
 1.47A 2ygpA-2ygoA:
29.0		 2ygpA-2ygoA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		11 / 12 LEU A  38
ILE A  40
ILE A  57
PRO A  78
ILE A  80
PRO A  81
MET A  87
PHE A  89
PHE A 103
PHE A 138
VAL A 154
 PCF  A1213 ( 3.9A)
None
PCF  A1213 ( 4.8A)
PCF  A1213 (-4.0A)
None
None
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
None
None
PCF  A1213 ( 4.7A)
 0.52A 2ygqA-2ygoA:
26.4		 2ygqA-2ygoA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		8 / 12 LEU A  38
ILE A  40
LEU A  48
ILE A  57
MET A  87
PHE A  89
PHE A 103
VAL A 154
 PCF  A1213 ( 3.9A)
None
PCF  A1213 (-4.3A)
PCF  A1213 ( 4.8A)
PCF  A1213 ( 3.8A)
PCF  A1213 (-4.1A)
None
PCF  A1213 ( 4.7A)
 0.64A 2ygqA-2ygoA:
26.4		 2ygqA-2ygoA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A  38
ILE A  40
PRO A  81
PHE A  89
PHE A 103
VAL A 154
 PCF  A1213 ( 3.9A)
None
None
PCF  A1213 (-4.1A)
None
PCF  A1213 ( 4.7A)
 1.38A 2ygqA-2ygoA:
26.4		 2ygqA-2ygoA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 7 ASN A 170
ILE A 172
PHE A 174
GLN A  74
 None
 1.13A 3tvxB-2ygoA:
undetectable		 3tvxB-2ygoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1213 (-4.3A)
None
PCF  A1213 ( 4.6A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 3.8A)
 1.08A 4y0pA-2ygoA:
undetectable		 4y0pA-2ygoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1213 (-4.3A)
None
PCF  A1213 ( 4.6A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 3.8A)
 1.13A 4y0qA-2ygoA:
undetectable		 4y0qA-2ygoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		3 / 3 GLU A 194
HIS A  85
ARG A 195
 None
 0.97A 5uunA-2ygoA:
undetectable		 5uunA-2ygoA:
19.93