SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ygq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		3 / 3 TYR A 101
VAL A 121
THR A 126
 None
 0.30A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		10 / 12 LEU A  36
ILE A  40
ILE A  55
MET A  63
MET A  77
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
 None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
 0.42A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		10 / 12 LEU A  36
ILE A  40
LEU A  48
ILE A  55
MET A  63
MET A  77
MET A  87
PHE A  89
VAL A 152
VAL A 154
 None
None
PCF  A1275 (-4.6A)
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-3.2A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
 0.69A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A 165
ILE A  40
ILE A  55
ILE A  80
MET A  87
PHE A  89
 None
None
PCF  A1275 ( 4.4A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
 1.38A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A 165
ILE A  40
ILE A  55
ILE A  84
MET A  87
PHE A  89
 None
None
PCF  A1275 ( 4.4A)
None
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
 1.33A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 5 ILE A  49
PHE A  66
VAL A 156
PHE A 173
 PCF  A1275 (-4.7A)
None
None
PCF  A1275 ( 4.5A)
 0.67A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 5 PHE A  66
PRO A  78
VAL A 156
PHE A 173
 None
PCF  A1275 (-4.1A)
None
PCF  A1275 ( 4.5A)
 0.48A 2ygnA-2ygqA:
26.1		 2ygnA-2ygqA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 ILE A  40
ILE A  55
ILE A  57
ILE A  84
PHE A  89
VAL A 152
 None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
 1.39A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 ILE A  40
ILE A  55
ILE A  57
PHE A  66
PHE A  89
VAL A 152
 None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
 1.25A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		7 / 12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
ILE A  84
MET A  87
PHE A  89
 None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
None
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
 1.29A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  38
ILE A  40
ILE A  55
ILE A  57
MET A  63
PHE A  66
ILE A  80
MET A  87
PHE A  89
VAL A 152
VAL A 154
PHE A 173
 None
None
PCF  A1275 ( 4.4A)
PCF  A1275 ( 4.5A)
PCF  A1275 ( 4.1A)
None
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
PCF  A1275 ( 4.5A)
 0.39A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 12 LEU A  38
ILE A  40
ILE A  57
MET A  63
ILE A  80
PHE A 173
 None
None
PCF  A1275 ( 4.5A)
PCF  A1275 ( 4.1A)
PCF  A1275 (-4.7A)
PCF  A1275 ( 4.5A)
 1.10A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 6 LEU A  48
ILE A  49
MET A  77
VAL A 156
 PCF  A1275 (-4.6A)
PCF  A1275 (-4.7A)
PCF  A1275 (-3.2A)
None
 0.95A 2ygoA-2ygqA:
26.4		 2ygoA-2ygqA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		10 / 12 LEU A  38
ILE A  40
ILE A  57
MET A  87
TRP A  91
PHE A 138
PHE A 150
VAL A 152
VAL A 154
PHE A 173
 None
None
PCF  A1275 ( 4.5A)
PCF  A1275 (-3.2A)
None
None
None
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
PCF  A1275 ( 4.5A)
 0.39A 2ygpA-2ygqA:
26.2		 2ygpA-2ygqA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		9 / 12 LEU A  38
ILE A  40
LEU A  48
ILE A  57
MET A  87
TRP A  91
VAL A 152
VAL A 154
PHE A 173
 None
None
PCF  A1275 (-4.6A)
PCF  A1275 ( 4.5A)
PCF  A1275 (-3.2A)
None
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
PCF  A1275 ( 4.5A)
 0.66A 2ygpA-2ygqA:
26.2		 2ygpA-2ygqA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		10 / 12 LEU A  38
ILE A  57
MET A  87
TRP A  91
PHE A 138
PHE A 150
VAL A 152
VAL A 154
PRO A 168
PHE A 173
 None
PCF  A1275 ( 4.5A)
PCF  A1275 (-3.2A)
None
None
None
PCF  A1275 (-3.6A)
PCF  A1275 (-4.9A)
None
PCF  A1275 ( 4.5A)
 0.63A 2ygpA-2ygqA:
26.2		 2ygpA-2ygqA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 9 ILE A  49
ILE A  55
PHE A  66
PHE A  89
VAL A 156
 PCF  A1275 (-4.7A)
PCF  A1275 ( 4.4A)
None
PCF  A1275 (-4.6A)
None
 0.67A 2ygpA-2ygqA:
26.2		 2ygpA-2ygqA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		6 / 9 ILE A  55
PHE A  66
PRO A  78
ILE A  80
PHE A  89
VAL A 156
 PCF  A1275 ( 4.4A)
None
PCF  A1275 (-4.1A)
PCF  A1275 (-4.7A)
PCF  A1275 (-4.6A)
None
 0.60A 2ygpA-2ygqA:
26.2		 2ygpA-2ygqA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		12 / 12 LEU A  38
ILE A  40
LEU A  48
ILE A  57
PRO A  78
ILE A  80
PRO A  81
MET A  87
PHE A  89
PHE A 103
PHE A 138
VAL A 154
 None
None
PCF  A1275 (-4.6A)
PCF  A1275 ( 4.5A)
PCF  A1275 (-4.1A)
PCF  A1275 (-4.7A)
PCF  A1275 (-4.6A)
PCF  A1275 (-3.2A)
PCF  A1275 (-4.6A)
PCF  A1275 (-4.6A)
None
PCF  A1275 (-4.9A)
 0.00A 2ygqA-2ygqA:
38.3		 2ygqA-2ygqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 ILE A 263
LEU A 104
GLY A 125
PHE A 257
MET A 157
 None
 1.16A 3k2hA-2ygqA:
undetectable		 3k2hA-2ygqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 ILE A 263
LEU A 104
GLY A 125
PHE A 257
MET A 157
 None
 1.15A 3k2hB-2ygqA:
undetectable		 3k2hB-2ygqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		4 / 7 ASN A 170
ILE A 172
PHE A 174
GLN A  74
 None
 1.15A 3tvxB-2ygqA:
undetectable		 3tvxB-2ygqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens) 		5 / 12 ILE A 263
LEU A 104
GLY A 125
PHE A 257
MET A 157
 None
 1.20A 6r2eE-2ygqA:
undetectable		 6r2eE-2ygqA:
20.60