SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ygt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 6 PRO A  88
LEU A 246
ILE A  69
SER A  40
 None
 1.20A 1sbrA-2ygtA:
undetectable
1sbrB-2ygtA:
1.7		 1sbrA-2ygtA:
20.74
1sbrB-2ygtA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		3 / 3 PHE A 175
ARG A  86
ASN A 251
 None
 0.85A 1xzxX-2ygtA:
undetectable		 1xzxX-2ygtA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0H_B_ACHB1289_0
(FICOLIN-2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.29A 2j0hB-2ygtA:
0.0		 2j0hB-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0H_C_ACHC1289_0
(FICOLIN-2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.21A 2j0hC-2ygtA:
0.0		 2j0hC-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0H_F_ACHF1289_0
(FICOLIN-2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.20A 2j0hF-2ygtA:
0.0		 2j0hF-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1289_1
(FICOLIN-2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.29A 2j2pB-2ygtA:
0.0		 2j2pB-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1290_1
(FICOLIN-2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.39A 2j2pC-2ygtA:
0.0		 2j2pC-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1290_1
(FICOLIN-2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.30A 2j2pF-2ygtA:
0.0		 2j2pF-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		5 / 12 ILE A 115
THR A 117
VAL A 120
SER A 135
PRO A 111
 None
 1.18A 3kpbC-2ygtA:
undetectable		 3kpbC-2ygtA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 4 TYR A 157
THR A 178
VAL A 184
ILE A 219
 None
 1.45A 4jx1F-2ygtA:
undetectable		 4jx1F-2ygtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		5 / 11 LYS A 239
LEU A 279
ALA A  48
VAL A  46
ILE A  63
 None
 1.11A 4x20D-2ygtA:
undetectable		 4x20D-2ygtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 7 GLY A 130
THR A  60
VAL A 230
ASP A 108
 None
None
None
ZN  A1292 ( 4.5A)
 0.81A 5ik1A-2ygtA:
undetectable		 5ik1A-2ygtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		4 / 8 PRO A 111
TYR A 152
ASN A 172
SER A 109
 None
None
None
ZN  A1292 ( 4.7A)
 1.11A 5l1fA-2ygtA:
undetectable
5l1fB-2ygtA:
undetectable		 5l1fA-2ygtA:
16.25
5l1fB-2ygtA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		3 / 3 ASN A 136
PRO A 111
GLN A 161
 None
None
ZN  A1292 ( 4.8A)
 0.90A 6jnhA-2ygtA:
undetectable		 6jnhA-2ygtA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2ygt DELTA TOXIN
(Clostridium
perfringens) 		3 / 3 ASN A 136
PRO A 111
GLN A 161
 None
None
ZN  A1292 ( 4.8A)
 0.87A 6jogA-2ygtA:
undetectable		 6jogA-2ygtA:
20.07