SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.35A 1d4fA-2yh0A:
undetectable		 1d4fA-2yh0A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.36A 1d4fB-2yh0A:
undetectable		 1d4fB-2yh0A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.27A 1d4fD-2yh0A:
undetectable		 1d4fD-2yh0A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 VAL A 275
LEU A 266
LEU A 320
LEU A 330
TYR A 307
 None
 1.05A 2a15A-2yh0A:
undetectable		 2a15A-2yh0A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.30A 3g1uA-2yh0A:
undetectable		 3g1uA-2yh0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.31A 3g1uB-2yh0A:
undetectable		 3g1uB-2yh0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.31A 3g1uC-2yh0A:
undetectable		 3g1uC-2yh0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.31A 3g1uD-2yh0A:
undetectable		 3g1uD-2yh0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.27A 3glqA-2yh0A:
undetectable		 3glqA-2yh0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.29A 3glqB-2yh0A:
undetectable		 3glqB-2yh0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 279
LEU A 325
LEU A 266
GLY A 301
PHE A 288
 None
 1.22A 3n58A-2yh0A:
undetectable		 3n58A-2yh0A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A 277
GLY A 183
SER A 281
 None
 0.65A 4b53B-2yh0A:
undetectable		 4b53B-2yh0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 GLU A 207
ALA A 211
ALA A 171
GLY A 176
LEU A 175
 None
 0.85A 4oaeA-2yh0A:
undetectable		 4oaeA-2yh0A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 178
PHE A 214
ASP A 215
ALA A 211
ILE A 218
 None
 1.38A 4uuuA-2yh0A:
undetectable
4uuuB-2yh0A:
undetectable		 4uuuA-2yh0A:
20.87
4uuuB-2yh0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 GLY A 183
ASN A 184
PRO A 185
ALA A 181
GLN A 180
 None
 1.30A 5c8tD-2yh0A:
0.3		 5c8tD-2yh0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		4 / 5 PRO A 284
ALA A 188
GLN A 315
GLN A 190
 None
 1.34A 5odcA-2yh0A:
undetectable
5odcG-2yh0A:
undetectable		 5odcA-2yh0A:
14.83
5odcG-2yh0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 312
TYR A 307
GLU A 201
 None
 0.90A 5zmqD-2yh0A:
undetectable
5zmqE-2yh0A:
undetectable		 5zmqD-2yh0A:
22.44
5zmqE-2yh0A:
21.00