SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 157
PHE A 217
HIS A 284
 None
 0.94A 1dx6A-2yh2A:
19.2		 1dx6A-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.12A 1dz4A-2yh2A:
undetectable		 1dz4A-2yh2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.15A 1dz4B-2yh2A:
undetectable		 1dz4B-2yh2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 VAL A  26
LEU A  89
GLU A  34
HIS A  83
SER A  91
 None
 1.33A 1fdtA-2yh2A:
4.5		 1fdtA-2yh2A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 GLY A  85
GLY A  86
SER A 157
LEU A 213
HIS A 284
 None
 0.95A 1mx1A-2yh2A:
19.4		 1mx1A-2yh2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A  85
GLY A  86
SER A 157
LEU A 213
HIS A 284
 None
 0.89A 1mx1F-2yh2A:
19.3		 1mx1F-2yh2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 157
PHE A 217
HIS A 284
 None
 0.93A 1qtiA-2yh2A:
2.0		 1qtiA-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 5 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.16A 1t88B-2yh2A:
undetectable		 1t88B-2yh2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		3 / 3 ASP A  23
ARG A  21
ASP A  25
 None
 0.79A 1vptA-2yh2A:
undetectable		 1vptA-2yh2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 157
PHE A 217
HIS A 284
 None
 0.95A 1w6rA-2yh2A:
19.1		 1w6rA-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 GLY A  85
GLY A  86
SER A 157
PHE A 217
HIS A 284
 None
 0.94A 1w76A-2yh2A:
17.9		 1w76A-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 10 GLY A  84
GLY A  85
SER A 157
PHE A 217
HIS A 284
 None
 0.90A 1w76B-2yh2A:
18.2		 1w76B-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 4 GLY A  84
SER A 157
ILE A 208
HIS A 284
 None
 1.30A 1yajJ-2yh2A:
8.3		 1yajJ-2yh2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 9 GLY A  84
GLY A  85
SER A 157
ALA A 158
HIS A 284
 None
 0.91A 2aceA-2yh2A:
4.6		 2aceA-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 9 GLY A  85
GLY A  86
SER A 157
ALA A 158
PHE A 217
HIS A 284
 None
 0.88A 2aceA-2yh2A:
4.6		 2aceA-2yh2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 7 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.06A 2cppA-2yh2A:
undetectable		 2cppA-2yh2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 TYR A 201
GLY A 281
TYR A 206
ASN A 280
 None
 1.26A 2g72A-2yh2A:
2.4		 2g72A-2yh2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 8 GLY A  85
GLY A  86
ALA A 158
PHE A 217
HIS A 284
 None
 0.96A 2ha4A-2yh2A:
18.8		 2ha4A-2yh2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 7 GLY A  85
GLY A  86
ALA A 158
PHE A 217
HIS A 284
 None
 0.97A 2ha4B-2yh2A:
19.2		 2ha4B-2yh2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 5 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.13A 2m56A-2yh2A:
undetectable		 2m56A-2yh2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 5 LEU A  11
ILE A   6
SER A   4
GLY A 281
 None
 0.81A 2otfA-2yh2A:
undetectable		 2otfA-2yh2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 MET A 169
ALA A 126
ASN A 161
GLY A 160
LEU A 190
 None
 1.44A 3aodC-2yh2A:
undetectable		 3aodC-2yh2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.12A 3fwgA-2yh2A:
undetectable		 3fwgA-2yh2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 7 MET A  43
ILE A 292
ILE A  10
GLN A  13
 None
 1.04A 3hgxA-2yh2A:
undetectable		 3hgxA-2yh2A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 7 GLY A  85
GLY A  86
SER A 157
HIS A 284
 None
 0.40A 3o9mA-2yh2A:
19.4		 3o9mA-2yh2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 GLY A  85
GLY A  86
SER A 157
HIS A 284
 None
 0.46A 3o9mB-2yh2A:
19.4		 3o9mB-2yh2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A 158
GLY A 159
TYR A  82
ALA A 118
PHE A 217
 None
 1.09A 3qxyA-2yh2A:
undetectable		 3qxyA-2yh2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 ALA A 158
GLY A 159
TYR A  82
ALA A 118
PHE A 217
 None
 1.11A 3qxyB-2yh2A:
undetectable
3qxyQ-2yh2A:
undetectable		 3qxyB-2yh2A:
22.41
3qxyQ-2yh2A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 ALA A 158
GLY A 159
TYR A  82
ALA A 118
PHE A 217
 None
 1.12A 3rc0A-2yh2A:
undetectable		 3rc0A-2yh2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A 158
GLY A 159
TYR A  82
ALA A 118
PHE A 217
 None
 1.11A 3rc0B-2yh2A:
undetectable		 3rc0B-2yh2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 TYR A  82
GLY A 160
GLY A 260
ALA A 246
ALA A 274
 None
 1.17A 3sufC-2yh2A:
undetectable		 3sufC-2yh2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A 160
VAL A  80
GLY A 260
ALA A 246
ALA A 274
 None
 0.92A 3sufD-2yh2A:
undetectable		 3sufD-2yh2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 HIS A 284
GLY A  86
GLY A  84
TYR A 185
ALA A 118
 None
 1.17A 3vywB-2yh2A:
2.1		 3vywB-2yh2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A  86
GLY A  84
TYR A 185
ALA A 118
PHE A  33
 None
 1.08A 3vywD-2yh2A:
undetectable		 3vywD-2yh2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 HIS A 284
GLY A  86
GLY A  84
TYR A 185
ALA A 118
 None
 1.16A 3vywD-2yh2A:
undetectable		 3vywD-2yh2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.13A 3wrhE-2yh2A:
undetectable		 3wrhE-2yh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.11A 3wrjE-2yh2A:
undetectable		 3wrjE-2yh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 157
PHE A 217
HIS A 284
 None
 0.92A 4ey6A-2yh2A:
8.1		 4ey6A-2yh2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 157
PHE A 217
HIS A 284
 None
 0.92A 4ey6B-2yh2A:
18.5		 4ey6B-2yh2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 GLY A  85
SER A 157
TRP A 216
HIS A 284
GLY A 285
 None
 1.32A 4ey7A-2yh2A:
19.5		 4ey7A-2yh2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 GLY A  85
SER A 157
TRP A 216
HIS A 284
GLY A 285
 None
 1.34A 4ey7B-2yh2A:
19.2		 4ey7B-2yh2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 GLU A  34
LEU A  40
ASP A 156
GLY A  84
TYR A 185
 None
 1.44A 4foxC-2yh2A:
undetectable		 4foxC-2yh2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 GLU A  34
LEU A  40
ASP A 156
GLY A  84
TYR A 185
 None
 1.45A 4foxF-2yh2A:
undetectable		 4foxF-2yh2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.13A 4g3rA-2yh2A:
undetectable		 4g3rA-2yh2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.12A 4g3rB-2yh2A:
undetectable		 4g3rB-2yh2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 6 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.12A 4kkyX-2yh2A:
undetectable		 4kkyX-2yh2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 5 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.17A 4l49A-2yh2A:
undetectable		 4l49A-2yh2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A 160
ALA A 158
THR A  94
HIS A  95
GLY A  85
 None
 0.86A 4ls7A-2yh2A:
undetectable		 4ls7A-2yh2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 11 ASN A 161
PHE A  87
LEU A 190
GLY A  86
LEU A 256
 None
 1.31A 4zbqA-2yh2A:
undetectable		 4zbqA-2yh2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 ASN A 161
PHE A  87
LEU A 190
GLY A  86
LEU A 256
 None
 1.21A 4zbrA-2yh2A:
undetectable		 4zbrA-2yh2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A 293
ARG A 101
THR A 250
ASP A 254
PHE A 289
 None
 1.49A 5gpgB-2yh2A:
0.5		 5gpgB-2yh2A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		3 / 3 ILE A  56
PRO A  57
ILE A  63
 None
 0.41A 5hw8F-2yh2A:
undetectable		 5hw8F-2yh2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		3 / 3 ASP A 172
ASN A 242
PHE A 237
 None
 0.92A 5jglB-2yh2A:
undetectable		 5jglB-2yh2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 8 ILE A 184
TYR A 180
VAL A 277
ASP A 254
 None
 1.04A 5vlmF-2yh2A:
undetectable		 5vlmF-2yh2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		4 / 7 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.04A 5wk9A-2yh2A:
undetectable		 5wk9A-2yh2A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A   3
ILE A 283
LEU A  40
ILE A  10
HIS A  95
 None
 1.20A 5y2tB-2yh2A:
undetectable		 5y2tB-2yh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A 102
VAL A  98
ILE A 249
ILE A 184
ASP A 156
 None
 1.25A 5yf9X-2yh2A:
undetectable		 5yf9X-2yh2A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A 102
VAL A  98
VAL A 300
ILE A 184
ASP A 156
 None
 1.26A 5yf9X-2yh2A:
undetectable		 5yf9X-2yh2A:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 2yh2 ESTERASE
(Pyrobaculum
calidifontis) 		6 / 11 HIS A  95
ASP A 156
LEU A 209
HIS A 284
GLY A 285
PHE A  33
 None
 0.44A 6ieyA-2yh2A:
39.0
6ieyB-2yh2A:
38.9		 6ieyA-2yh2A:
44.34
6ieyB-2yh2A:
44.34