SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		4 / 8 ASN A 729
SER A 688
ARG A 722
ALA A 731
 None
 1.11A 1rqpA-2yhaA:
undetectable		 1rqpA-2yhaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		5 / 12 MET A 869
PHE A 743
ILE A 779
THR A 658
LEU A 652
 None
 1.29A 2bjfA-2yhaA:
undetectable		 2bjfA-2yhaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		4 / 8 ASN A 729
SER A 688
ARG A 722
ALA A 731
 None
 1.11A 2v7uA-2yhaA:
undetectable		 2v7uA-2yhaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		3 / 3 VAL A 635
LYS A 638
HIS A 580
 None
SO4  A1939 (-3.0A)
None
 0.87A 3elzA-2yhaA:
undetectable		 3elzA-2yhaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		4 / 4 VAL A 532
PHE A 554
PHE A 582
VAL A 611
 None
None
None
SO4  A1939 (-3.9A)
 1.36A 3rv5C-2yhaA:
undetectable
3rv5D-2yhaA:
undetectable		 3rv5C-2yhaA:
14.92
3rv5D-2yhaA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		3 / 3 GLN A 753
ASP A 758
GLN A 708
 None
 0.92A 4aztA-2yhaA:
undetectable		 4aztA-2yhaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		4 / 5 TYR A 937
THR A 546
LEU A 543
THR A 610
 None
 1.50A 4mbsB-2yhaA:
undetectable		 4mbsB-2yhaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		3 / 3 SER A 934
ALA A 699
VAL A 687
 None
 0.60A 4o2bC-2yhaA:
2.2		 4o2bC-2yhaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		3 / 3 SER A 934
ALA A 699
VAL A 687
 None
 0.62A 4x20C-2yhaA:
undetectable		 4x20C-2yhaA:
18.50