SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
4 / 5 TYR A 663
VAL A 755
VAL A 785
ASP A 745
None
1.49A 1dz6B-2yhbA:
undetectable
1dz6B-2yhbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
3 / 3 VAL A 635
LYS A 638
HIS A 580
None
SO4  A1939 (-3.4A)
None
0.74A 3elzA-2yhbA:
undetectable
3elzA-2yhbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
5 / 12 PHE A 539
ILE A 550
MET A 577
VAL A 598
LEU A 523
None
1.38A 3em0B-2yhbA:
undetectable
3em0B-2yhbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
3 / 3 ARG A 600
VAL A 608
THR A 610
None
0.86A 3nduD-2yhbA:
undetectable
3nduD-2yhbA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
4 / 4 VAL A 532
PHE A 554
PHE A 582
VAL A 611
None
None
None
SO4  A1939 ( 4.2A)
1.40A 3rv5C-2yhbA:
undetectable
3rv5D-2yhbA:
undetectable
3rv5C-2yhbA:
13.63
3rv5D-2yhbA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
3 / 3 SER A 934
ALA A 699
VAL A 687
None
0.61A 4o2bC-2yhbA:
2.0
4o2bC-2yhbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
3 / 3 ALA A 509
GLN A 692
GLY A 656
None
0.60A 4odoC-2yhbA:
undetectable
4odoC-2yhbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa)
3 / 3 SER A 934
ALA A 699
VAL A 687
None
0.59A 4x20C-2yhbA:
undetectable
4x20C-2yhbA:
20.33